{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:50:02Z","timestamp":1773323402860,"version":"3.50.1"},"reference-count":16,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"3","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100021068","name":"Universidad de Las Am\u00e9ricas Ecuador","doi-asserted-by":"publisher","award":["490.B.XIV.24 MCH"],"award-info":[{"award-number":["490.B.XIV.24 MCH"]}],"id":[{"id":"10.13039\/100021068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021068","name":"Universidad de Las Am\u00e9ricas Ecuador","doi-asserted-by":"publisher","award":["490.B.XIV.24 MCH"],"award-info":[{"award-number":["490.B.XIV.24 MCH"]}],"id":[{"id":"10.13039\/100021068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Se informa el primer caso documentado del s\u00edndrome cut\u00e1neo hemorr\u00e1gico \u2013inducido por contacto con orugas venenosas\u2013 en una mujer de 29 a\u00f1os, residente en el norte de la Amazon\u00eda ecuatoriana. Los casos reportados de este s\u00edndrome son raros y se caracterizan por lesiones d\u00e9rmicas, hemorragias sist\u00e9micas y alteraciones de la coagulaci\u00f3n.La mujer tuvo contacto en el muslo derecho con orugas que reposaban sobre el tronco de un \u00e1rbol. Esto result\u00f3 en irritaci\u00f3n y dolor locales, seguidos de cefalea, mareos y v\u00f3mito. A las 48 horas, present\u00f3 equimosis en el sitio de contacto, el cuello, el t\u00f3rax, el abdomen y las extremidades. La paciente fue hospitalizada. Present\u00f3 hemorragia vaginal abundante y prolongaci\u00f3n de los tiempos de coagulaci\u00f3n, aunque con un n\u00famero normal de plaquetas.Fue tratada con paracetamol y \u00e1cido tranex\u00e1mico, con lo cual se control\u00f3 el sangrado y se normalizaron los par\u00e1metros de coagulaci\u00f3n. Se le dio de alta en buenas condiciones y, a los seis meses de seguimiento, permanec\u00eda asintom\u00e1tica.Aunque en la Amazon\u00eda ecuatoriana se registran orugas del g\u00e9nero Lonomia, este es el primer caso diagnosticado. Se destaca la falta de disponibilidad de suero antilon\u00f3mico en la regi\u00f3n, lo que subraya la necesidad de implementar estrategias para garantizar el acceso al suero, y promover la concienciaci\u00f3n m\u00e9dica y comunitaria del s\u00edndrome cut\u00e1neo hemorr\u00e1gico por contacto con Lonomia spp. en \u00e1reas end\u00e9micas.<\/jats:p>","DOI":"10.7705\/biomedica.7532","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T18:50:07Z","timestamp":1755283807000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["S\u00edndrome cut\u00e1neo-hemorr\u00e1gico por contacto con orugas de Lonomia spp.: primer reporte de la Amazon\u00eda ecuatoriana","Hemorraghic skin syndrome associated with contact of Lonomia spp. caterpillar: First report from the Ecuadorian Amazon"],"prefix":"10.7705","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-0747","authenticated-orcid":false,"given":"Manuel","family":"Calvopina","sequence":"first","affiliation":[{"name":"One Health Research Group, Facultad de Medicina, Universidad de las Am\u00e9ricas, Quito, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-3758","authenticated-orcid":false,"given":"El\u00edas","family":"Guam\u00e1n-Charco","sequence":"additional","affiliation":[{"name":"Hospital \u201cMarco Vinicio Iza\u201d, Ministerio de Salud P\u00fablica del Ecuador, Nueva Loja, Sucumb\u00edos, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-0301","authenticated-orcid":false,"given":"Jasm\u00edn","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Hospital \u201cMarco Vinicio Iza\u201d, Ministerio de Salud P\u00fablica del Ecuador, Nueva Loja, Sucumb\u00edos, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7753-0989","authenticated-orcid":false,"given":"Bel\u00e9n","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Hospital \u201cMarco Vinicio Iza\u201d, Ministerio de Salud P\u00fablica del Ecuador, Nueva Loja, Sucumb\u00edos, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-4056","authenticated-orcid":false,"given":"Camila","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biol\u00f3gicas, Centro de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda Tropical - CIMPAT, Universidad de los Andes, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"150275","unstructured":"1. Montalb\u00e1n-Sandoval E, Bustinza-\u00c1lvarez A, V\u00edlchez G, Olarte L, Velarde-Marca J, Magui\u00f1a-Vargas C. Erucismo por Lonomia spp. con s\u00edndrome cut\u00e1neo hemorr\u00e1gico. Primer caso reportado en Per\u00fa \u20132006. Dermatol Peru. 2008;18:354-8."},{"key":"150276","doi-asserted-by":"crossref","unstructured":"2. Santos JH, Oliveira SS, Alves EC, Mendon\u00e7a-da-Silva I, Sachett JA, Tavares A, et al. Severe hemorrhagic syndrome after Lonomia caterpillar envenomation in the Western Brazilian Amazon: How many more cases are there? Wilderness Environ Med. 2017;28:46-50. https:\/\/doi.org\/10.1016\/j.wem.2016.11.001","DOI":"10.1016\/j.wem.2016.11.001"},{"key":"150277","unstructured":"3. Hern\u00e1ndez-Villarroel LA. Hemorrhagic syndrome associated with contact with Lonomia sp (Lepidoptera, Saturniidae) in Venezuela. Rev Cubana Med Trop. 2023;75:e1039."},{"key":"150278","doi-asserted-by":"crossref","unstructured":"4. Gonz\u00e1lez C, Ballesteros-Mej\u00eda L, D\u00edaz-D\u00edaz J, Toro-Vargas DM, Amarillo-Su\u00e1rez AR, Gey D, et al. Deadly and venomous Lonomia caterpillars are more than the two usual suspects. PLoS Negl Trop Dis. 2023;17:e0011063. https:\/\/doi.org\/10.1371\/journal.pntd.0011063","DOI":"10.1371\/journal.pntd.0011063"},{"key":"150279","doi-asserted-by":"crossref","unstructured":"5. Sano-Martins IS, Gonzalez C, Anjos IV, D\u00edaz J, Goncalves LR. Effectiveness of Lonomia antivenom in recovery from the coagulopathy induced by Lonomia orientoandensis and Lonomia casanarensis caterpillars in rats. PLoS Negl Trop Dis. 2018;12:e0006721. https:\/\/doi.org\/10.1371\/journal.pntd.0006721","DOI":"10.1371\/journal.pntd.0006721"},{"key":"150280","doi-asserted-by":"crossref","unstructured":"6. Lemaire C. R\u00e9vision du genre Lonomia Walker (Lep. Attacidae). Ann Soc Ent Fr. 1972;8:707-861.","DOI":"10.1080\/21686351.1972.12278121"},{"key":"150281","unstructured":"7. Funda\u00e7\u00e3o Nacional de Sa\u00fade - FUNASA. Manual de diagn\u00f3stico e tratamento de accidentes por animais pe\u00e7onhentos. 2\u00aa edi\u00e7\u00e3o. Bras\u00edlia: Funda\u00e7\u00e3o Nacional de Sa\u00fade; 2001. p. 120."},{"key":"150282","doi-asserted-by":"crossref","unstructured":"8. Da Silva WD, Campos CM, Gon\u00e7alves LR, Sousa-e-Silva MC, Higashi HG, Yamagushi IK, et al. Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon. 1996;34:1045-9. https:\/\/doi.org\/10.1016\/0041-0101(96)00052-9","DOI":"10.1016\/0041-0101(96)00052-9"},{"key":"150283","unstructured":"9. 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Biom\u00e9dica. 2001;21:328-32. https:\/\/doi.org\/10.7705\/biomedica.v21i4.1125","DOI":"10.7705\/biomedica.v21i4.1125"},{"key":"150286","doi-asserted-by":"crossref","unstructured":"12. Gon\u00e7alves LR, Sousa-e-Silva MC, Tomy SC, Sano-Martins IS. Efficacy of serum therapy on the treatment of rats experimentally envenomed by bristle extract of the caterpillar Lonomia obliqua: Comparison with epsilon-aminocaproic acid therapy. Toxicon. 2007;50:349-56. https:\/\/doi.org\/10.1016\/j.toxicon.2007.04.004","DOI":"10.1016\/j.toxicon.2007.04.004"},{"key":"150287","doi-asserted-by":"crossref","unstructured":"13. Bryant-Smith AC, Lethaby A, Farquhar C, Hickey M. Antifibrinolytics for heavy menstrual bleeding. Cochrane Database Syst Rev. 2018;4:CD000249.","DOI":"10.1002\/14651858.CD000249.pub2"},{"key":"150288","unstructured":"https:\/\/doi.org\/10.1002\/14651858.CD000249.pub214. World Health Organization. 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