{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:39:25Z","timestamp":1773365965449,"version":"3.50.1"},"reference-count":21,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>La enfermedad granulomatosa cr\u00f3nica es el error innato de la inmunidad que se acompa\u00f1a con mayor frecuencia de aspergilosis invasiva. En esta enfermedad, la aspergilosis invasiva se presenta en la adolescencia y es rara antes del a\u00f1o de vida. Se presenta el caso de un infante con enfermedad granulomatosa cr\u00f3nica y aspergilosis invasiva.Se trata de un lactante de sexo masculino de cuatro meses de edad, de madre hipotiroidea y con quien convive en la celda de la c\u00e1rcel. El infante present\u00f3 tumores en la regi\u00f3n axilar izquierda y la radiograf\u00eda de t\u00f3rax sugiri\u00f3 fracturas costales; fue hospitalizado ante la sospecha de maltrato infantil. En la tomograf\u00eda de t\u00f3rax se observ\u00f3 un absceso axilar, oste\u00f3lisis de costillas, neumon\u00eda y n\u00f3dulos pulmonares; el paciente recibi\u00f3 antibi\u00f3ticos de amplio espectro y fue dado de alta.A los ocho meses, reingres\u00f3 por fiebre y extensi\u00f3n del absceso purulento hacia la regi\u00f3n escapular izquierda; en la tomograf\u00eda se observaron im\u00e1genes de empeoramiento de la condici\u00f3n. Se aisl\u00f3 Aspergillus fumigatus de la secreci\u00f3n del absceso y se diagnostic\u00f3 aspergilosis invasiva; se inici\u00f3 tratamiento con voriconazol por 28 d\u00edas. Mediante la prueba de dihidrorrodamina, se diagnostic\u00f3 enfermedad granulomatosa cr\u00f3nica causada por la variante pat\u00f3gena c.80_83del\/Y del gen CYBB, portada por la madre (c.80_83del\/WT).A los 12 meses, el paciente reingres\u00f3 nuevamente por aspergilosis invasiva, resistente al tratamiento, con desenlace fatal.<\/jats:p>","DOI":"10.7705\/biomedica.7537","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:50:52Z","timestamp":1736437852000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Aspergilosis invasiva con compromiso \u00f3seo en lactante de cuatro meses con enfermedad granulomatosa cr\u00f3nica","Four-month-old infant with chronic granulomatous disease and invasive aspergillosis with bone involvement"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-2131","authenticated-orcid":false,"given":"H\u00e9ctor","family":"G\u00f3mez-Tello","sequence":"first","affiliation":[{"name":"Departamento de Alergias, Hospital para el Ni\u00f1o Poblano, Puebla, M\u00e9xico"},{"name":"Departamento de Alergias, Hospital para el Ni\u00f1o Poblano, Puebla, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-9134","authenticated-orcid":false,"given":"Estefany Graciela","family":"Mamani-Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico; Departamento de Pediatr\u00eda, Hospital del Ni\u00f1o \u201cDr. Ovidio Aliaga Ur\u00eda\u201d, La Paz, Bolivia"},{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico; Departamento de Pediatr\u00eda, Hospital del Ni\u00f1o \u201cDr. Ovidio Aliaga Ur\u00eda\u201d, La Paz, Bolivia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Karen","family":"G\u00f3mez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6263-442X","authenticated-orcid":false,"given":"Carlos","family":"S\u00e1nchez-Flores","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Lora-T\u00e9llez","sequence":"additional","affiliation":[{"name":"Laboratorio de Micobacteriosis y Micolog\u00eda M\u00e9dica, Hospital para el Ni\u00f1o Poblano, Puebla, M\u00e9xico"},{"name":"Laboratorio de Micobacteriosis y Micolog\u00eda M\u00e9dica, Hospital para el Ni\u00f1o Poblano, Puebla, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-3151","authenticated-orcid":false,"given":"Sara","family":"Espinosa-Padilla","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-8864","authenticated-orcid":false,"given":"Lizbeth","family":"Blancas-Galicia","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Laboratorio de Inmunodeficiencias, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"141642","doi-asserted-by":"crossref","unstructured":"Antachopoulos C, Walsh TJ, Roilides E. 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