{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:41:57Z","timestamp":1788309717768,"version":"build-2803163510"},"reference-count":43,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. La artritis psori\u00e1sica es una enfermedad compleja y los ant\u00edgenos leucocitarios humanos (Human Leukocyte Antigen, HLA) son un factor clave en el desarrollo de la enfermedad. En Latinoam\u00e9rica, hay pocos datos sobre dichos ant\u00edgenos en pacientes con artritis psori\u00e1sica.Objetivo. Describir la frecuencia de genotipos, alelos y haplotipos de los ant\u00edgenos leucocitarios humanos en casos de artritis psori\u00e1sica y asociarlos con variables cl\u00ednicas.Materiales y m\u00e9todos. Se desarroll\u00f3 un estudio retrospectivo del 2012 al 2023 en el que se evaluaron los adultos con artritis psori\u00e1sica seg\u00fan los criterios CASPAR. Se incluyeron controles sanos con HLA-A, B, C y DR tipificados por PCR\/SSO en un dispositivo Luminex 100\/200 xMAP\u2122. Se hizo un an\u00e1lisis comparativo entre los datos de los ant\u00edgenos leucocitarios de los pacientes y los de los controles sanos.Resultados. Se incluyeron 401 controles sanos y 37 pacientes con artritis psori\u00e1sica, entre los cuales se identificaron 46 genotipos, 75 alelos y 32 haplotipos. Los HLA m\u00e1s frecuentes fueron HLA-A*24 (37,1 %), HLA-B*35 (20,8 %), HLA-C*03 y HLA-C*07 (cada uno con el 19,9 %) y HLA-DR*04 (30 %). Al comparar su frecuencia con la de los controles sanos, la frecuencia genot\u00edpica fue menor para HLA-A*02, HLA-A*11, HLA-B*35, HLA-DR*01, HLA-DR*07, HLA-DR*13 y HLA-DR*15 (p &lt; 0,05), lo que significa que, si bien el HLA-B*35 fue frecuente en la artritis psori\u00e1sica, su frecuencia fue menor al compararse con la de los controles. La frecuencia de HLA-A*24 y HLA-B*44 fue diferente en los pacientes con compromiso cut\u00e1neo (p &lt; 0,05); la de HLA-B*40 y HLA-B*35 en aquellos con compromiso articular (p &lt; 0,05), y la de HLA-A*26 y HLA-C*16 en aquellos con manifestaciones extraarticulares (p &lt; 0,05). La frecuencia al\u00e9lica de HLA-A*26:01 y HLA-C*16:01 en los casos con manifestaciones extraarticulares, fue tambi\u00e9n significativa. La frecuencia de HLA-Cw*6 fue 6,7 % y la ausencia de HLA-B*27 en nuestra poblaci\u00f3n es uno de los aspectos por destacar.Conclusiones. En el an\u00e1lisis de HLA en artritis psori\u00e1sica se encontr\u00f3tr\u00f3 una poca frecuencia de HLA-C*06 y ausencia de HLA-B*27. Este hallazgo es diferencial respecto a la poblaci\u00f3n cauc\u00e1sica. Estos resultados revelaron otros alelos de inter\u00e9s, algunos relacionados con variables cl\u00ednicas. Las diferencias encontradas podr\u00edan estar relacionadas con la mezcla racial de nuestra poblaci\u00f3n.<\/jats:p>","DOI":"10.7705\/biomedica.7555","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:50:52Z","timestamp":1736437852000},"page":"178-190","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["An\u00e1lisis de genotipos, alelos y haplotipos de HLA en un grupo de pacientes con artritis psori\u00e1sica: poca frecuencia de alelos comunes","Allelic and haplotypic HLA analysis in patients with psoriatic arthritis: Low frequency of common alleles"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-025X","authenticated-orcid":false,"given":"Omar-Javier","family":"Calixto","sequence":"first","affiliation":[{"name":"Servicio de Reumatolog\u00eda e Inmunolog\u00eda, Hospital Militar Central, Bogot\u00e1, D. 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