{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:34:15Z","timestamp":1773365655549,"version":"3.50.1"},"reference-count":20,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"Sp. 2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. La deficiencia de anticuerpos espec\u00edficos es un tipo de error innato de la inmunidad humoral, caracterizado por niveles normales de isotipos de inmunoglobulinas, infecciones recurrentes y reducci\u00f3n en la reacci\u00f3n vacunal ante ant\u00edgenos polisac\u00e1ridos.Objetivo. Describir las caracter\u00edsticas cl\u00ednicas e inmunol\u00f3gicas de pacientes con d\u00e9ficit de anticuerpos espec\u00edficos, atendidos en un hospital pedi\u00e1trico de Bogot\u00e1 entre mayo de 2021 y septiembre de 2023.Materiales y m\u00e9todos. Se revisaron las historias cl\u00ednicas de 16 pacientes con d\u00e9ficit de anticuerpos espec\u00edficos.Resultados. La edad mediana al diagn\u00f3stico fue de seis a\u00f1os y medio, 9 pacientes eran de sexo masculino y 7 ten\u00edan antecedentes de prematuridad. Once ten\u00edan un estado nutricional normal y 7 ten\u00edan una talla adecuada. La infecci\u00f3n recurrente m\u00e1s frecuente fue la neumon\u00eda en 12 pacientes y en m\u00e1s de la mitad, se acompa\u00f1\u00f3 de alguna complicaci\u00f3n. El fenotipo m\u00e1s frecuente fue el moderado y 15 recibieron inmunoglobulina como tratamiento definitivo.Conclusi\u00f3n. La deficiencia de anticuerpos espec\u00edficos es una alteraci\u00f3n funcional del sistema inmunol\u00f3gico frecuentemente subdiagnosticada. Se debe sospechar en pacientes con otitis media y neumon\u00edas recurrentes o complicadas por choque s\u00e9ptico, derrame pleural o neumon\u00eda necrosante.<\/jats:p>","DOI":"10.7705\/biomedica.7562","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:50:52Z","timestamp":1736437852000},"page":"72-79","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Caracter\u00edsticas cl\u00ednicas e inmunol\u00f3gicas de pacientes con d\u00e9ficit de anticuerpos espec\u00edficos contra ant\u00edgenos polisac\u00e1ridos en un hospital pedi\u00e1trico de Colombia","Clinical and immunological features of specific antibody deficiency in a pediatric hospital in Colombia"],"prefix":"10.7705","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-8401","authenticated-orcid":false,"given":"Lina M.","family":"Casta\u00f1o-Jaramillo","sequence":"first","affiliation":[{"name":"Servicio de Inmunolog\u00eda Cl\u00ednica y Alergia Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico de La Misericordia - HOMI, Bogot\u00e1, D. C., Colombia"},{"name":"Servicio de Inmunolog\u00eda Cl\u00ednica y Alergia Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico de La Misericordia - HOMI, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-9777","authenticated-orcid":false,"given":"Alejandra","family":"Munevar","sequence":"additional","affiliation":[{"name":"Neumolog\u00eda Pedi\u00e1trica, Universidad El Bosque, Bogot\u00e1, D. C., Colombia"},{"name":"Neumolog\u00eda Pedi\u00e1trica, Universidad El Bosque, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-6163","authenticated-orcid":false,"given":"Andrea Carolina","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Pediatr\u00eda, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"},{"name":"Pediatr\u00eda, Universidad Militar Nueva Granada, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-5984","authenticated-orcid":false,"given":"Milena","family":"Villamil","sequence":"additional","affiliation":[{"name":"Servicio de Neumolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico de La Misericordia - HOMI, Bogot\u00e1, D.C., Colombia;\u00a0Departamento Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"},{"name":"Servicio de Neumolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico de La Misericordia - HOMI, Bogot\u00e1, D.C., Colombia;\u00a0Departamento Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3870-4102","authenticated-orcid":false,"given":"Sonia","family":"Restrepo","sequence":"additional","affiliation":[{"name":"Servicio de Neumolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico de La Misericordia - HOMI, Bogot\u00e1, D.C., Colombia;\u00a0Departamento Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"},{"name":"Servicio de Neumolog\u00eda Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico de La Misericordia - HOMI, Bogot\u00e1, D.C., Colombia;\u00a0Departamento Pediatr\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-3679","authenticated-orcid":false,"given":"Natalia","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda Cl\u00ednica y Alergia Pedi\u00e1trica, Fundaci\u00f3n Hospital Pedi\u00e1trico de La Misericordia - HOMI, Bogot\u00e1, D. 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