{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:43:21Z","timestamp":1792489401935,"version":"4.5.0"},"reference-count":22,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"4","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. La toxoplasmosis cong\u00e9nita est\u00e1 asociada con una gran morbimortalidad durante el periodo neonatal. Aunque existe una gu\u00eda de pr\u00e1ctica cl\u00ednica colombiana para el diagn\u00f3stico y el tratamiento de la toxoplasmosis gestacional y cong\u00e9nita, se desconoce el grado de cumplimiento de sus recomendaciones.Objetivo. Evaluar la observancia de las recomendaciones de la gu\u00eda colombiana de pr\u00e1ctica cl\u00ednica para la toxoplasmosis cong\u00e9nita y gestacional en dos hospitales de Medell\u00edn entre el 2016 y el 2020.Materiales y m\u00e9todos. Se desarroll\u00f3 un estudio descriptivo en menores de un a\u00f1o con sospecha o diagn\u00f3stico confirmado de toxoplasmosis cong\u00e9nita en dos hospitales de Medell\u00edn entre el 2016 y el 2020. Se usaron frecuencias relativas para evaluar el cumplimiento de las recomendaciones.Resultados. Se incluyeron 247 ni\u00f1os; el 17 % fueron diagnosticados con toxoplasmosis cong\u00e9nita. La observancia de las diferentes recomendaciones de la gu\u00eda de pr\u00e1ctica cl\u00ednica colombiana fue variable. Para el diagn\u00f3stico de toxoplasmosis gestacional, se evaluaron las concentraciones de inmunoglobulinas G y M en el 85,4 % de las pacientes. Las recomendaciones sobre otras pruebas diagn\u00f3sticas se acataron del 20 al 41,5 % de los casos, seg\u00fan las diferentes circunstancias cl\u00ednicas. Se practic\u00f3 amniocentesis al 42,9 % de las mujeres gestantes con indicaci\u00f3n y se ordenaron serolog\u00edas de IgM, IgG e IgA al 50,6 % de los reci\u00e9n nacidos. Se prescribi\u00f3 espiramicina al 68,8 % de las madres con toxoplasmosis gestacional. El 80,9 % de los pacientes con toxoplasmosis cong\u00e9nita present\u00f3 manifestaciones cl\u00ednicas; aquellas relacionadas con el sistema nervioso central fueron las m\u00e1s comunes. La mayor observancia de la gu\u00eda de pr\u00e1ctica cl\u00ednica colombiana (96,7 %), fue respecto al tratamiento de la toxoplasmosis cong\u00e9nita.Conclusiones. La observancia de las recomendaciones de la gu\u00eda de pr\u00e1ctica cl\u00ednica colombiana es variable y depende de las barreras para su implementaci\u00f3n, como la falta de difusi\u00f3n de la gu\u00eda, la falta de actualizaci\u00f3n del personal de salud y las dificultades para acceder a estudios de diagn\u00f3stico y a un seguimiento adecuado. Se recomienda el desarrollo de pol\u00edticas institucionales y gubernamentales que garanticen la actualizaci\u00f3n peri\u00f3dica del personal encargado del control prenatal y de la atenci\u00f3n al reci\u00e9n nacido.<\/jats:p>","DOI":"10.7705\/biomedica.7590","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T21:45:14Z","timestamp":1758836714000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Observancia de las gu\u00edas de pr\u00e1ctica cl\u00ednica para la toxoplasmosis cong\u00e9nita en Colombia","Adherence to the Colombian guideline on congenital toxoplasmosis"],"prefix":"10.7705","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-9983","authenticated-orcid":false,"given":"Sara","family":"Correa-P\u00e9rez","sequence":"first","affiliation":[{"name":"Grupo en Investigaci\u00f3n Cl\u00ednica en Enfermedades del Ni\u00f1o y del Adolescente \u2013 Pediaciencias, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia;\u00a0Departamento de Pediatr\u00eda, Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1954-5913","authenticated-orcid":false,"given":"Mauricio Daniel","family":"Carrascal-Petro","sequence":"additional","affiliation":[{"name":"Grupo en Investigaci\u00f3n Cl\u00ednica en Enfermedades del Ni\u00f1o y del Adolescente \u2013 Pediaciencias, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia;\u00a0Departamento de Pediatr\u00eda, Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-1330","authenticated-orcid":false,"given":"Catalina","family":"Arango-Ferreira","sequence":"additional","affiliation":[{"name":"Grupo en Investigaci\u00f3n Cl\u00ednica en Enfermedades del Ni\u00f1o y del Adolescente \u2013 Pediaciencias, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia; Departamento de Infectolog\u00eda Pedi\u00e1trica, Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-8172","authenticated-orcid":false,"given":"Claudia Patricia","family":"Beltr\u00e1n-Arroyave","sequence":"additional","affiliation":[{"name":"Grupo en Investigaci\u00f3n Cl\u00ednica en Enfermedades del Ni\u00f1o y del Adolescente \u2013 Pediaciencias, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia; Departamento de Infectolog\u00eda Pedi\u00e1trica, Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-0801","authenticated-orcid":false,"given":"Javier Mauricio","family":"Sierra-Abaunza","sequence":"additional","affiliation":[{"name":"Grupo en Investigaci\u00f3n Cl\u00ednica en Enfermedades del Ni\u00f1o y del Adolescente \u2013 Pediaciencias, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia; Departamento de Pediatr\u00eda, Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"153252","doi-asserted-by":"crossref","unstructured":"Guedez IV, Barroso LA. 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