{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:49:59Z","timestamp":1773323399184,"version":"3.50.1"},"reference-count":14,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"3","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Snakebite envenomation remains a neglected public health problem in many tropical and subtropical countries. It mainly affects rural populations and has a higher incidence in men. Most cases have been reported in Africa, Latin America, and Asia. More than 300 species of snakes have been identified in Colombia, of which around 18% are of medical importance. This fact places the country as the third with the highest number of cases in the region, with 6,231 reported by 2023.Snakebite envenomation in pregnant women is a rare event, and it implies a higher risk of fetal and neonatal death. We report the case of a newborn with neonatal hypoxia and fetal distress, resulting from a cesarean section of a 22-year-old primigravida at 36 weeks of gestation after an ophidian accident involving a bite in the dorsum of her left hand. The newborn was admitted to the intensive care unit in critical condition and with progressive clinical deterioration. However, following the timely administration of antivenom and mechanical ventilation, the infant showed a remarkable recovery and was discharged after only 12 days of hospitalization.We underline the need to improve the availability of antivenoms and to strengthen pharmacovigilance systems to ensure their effectiveness and safety. In conclusion, this clinical case highlights the importance of an early consultation, the availability and prompt administration of the antivenom, and the expertise of healthcare workers in managing this event in pregnant women and neonates.<\/jats:p>","DOI":"10.7705\/biomedica.7595","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T18:50:07Z","timestamp":1755283807000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Bothropic snakebite in preterm pregnancy: Antivenom and clinical outcome in mother and newborn in C\u00facuta, Colombia","Accidente botr\u00f3pico en embarazo prematuro: administraci\u00f3n de antiveneno y desenlace en la madre y el neonato en C\u00facuta, Colombia"],"prefix":"10.7705","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7938-8164","authenticated-orcid":false,"given":"Diana Marcela","family":"Pava","sequence":"first","affiliation":[{"name":"Direcci\u00f3n de Producci\u00f3n, Instituto Nacional de Salud, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-4807","authenticated-orcid":false,"given":"Marisol","family":"Galindo","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Producci\u00f3n, Instituto Nacional de Salud, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-6676","authenticated-orcid":false,"given":"Juan Felipe","family":"Bedoya","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Producci\u00f3n, Instituto Nacional de Salud, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7020-9415","authenticated-orcid":false,"given":"Guadalupe","family":"Osorio","sequence":"additional","affiliation":[{"name":"Hospital Universitario Erasmo Meoz, C\u00facuta, Norte de Santander, Colombia"},{"name":"Hospital Universitario Erasmo Meoz, C\u00facuta, Norte de Santander, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6885-6353","authenticated-orcid":false,"given":"Mario Javier","family":"Olivera","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8449-763X","authenticated-orcid":false,"given":"Santiago","family":"Ayerbe","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad del Cauca, Popay\u00e1n, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-537X","authenticated-orcid":false,"given":"Jos\u00e9 Leonardo","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Producci\u00f3n, Instituto Nacional de Salud, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5394-0861","authenticated-orcid":false,"given":"Helver Guiovanni","family":"Rubiano","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General, Instituto Nacional de Salud, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"150342","doi-asserted-by":"crossref","unstructured":"1. Williams D, Guti\u00e9rrez JM, Harrison R, Warrell DA, White J, Winkel KD, et al. The Global Snake Bite Initiative. Lancet. 2010;375:89-91. https:\/\/doi.org\/10.1016\/S0140-6736(09)61159-4","DOI":"10.1016\/S0140-6736(09)61159-4"},{"key":"150343","unstructured":"2. Organizaci\u00f3n Mundial de la Salud. Mordeduras de serpientes venenosas \u2013 Notas descriptivas. Ginebra: Organizaci\u00f3n Mundial de la Salud; 2023."},{"key":"150344","unstructured":"3. Guti\u00e9rrez JM. Envenenamientos por mordeduras de serpientes en Am\u00e9rica Latina y el Caribe: Una visi\u00f3n integral de car\u00e1cter regional. Bol Mal Salud Amb. 2011;51:1-16."},{"key":"150345","unstructured":"4. Lynch J, Angarita-Sierra T, Ru\u00edz-G\u00f3mez F. Programa nacional para la conservaci\u00f3n de las serpientes presentes en Colombia. Bogot\u00e1, D. C.: Ministerio de Ambiente y Desarrollo Sostenible; Universidad Nacional de Colombia; Instituto Nacional de Salud; 2016. p. 128-32."},{"key":"150346","unstructured":"5. Bolet\u00edn Epidemiol\u00f3gico Semanal. Comportamiento epidemiol\u00f3gico del accidente of\u00eddico en Colombia I semestre 2023. Fecha de consulta: 26 de febrero de 2024. Disponible en: https:\/\/www.ins.gov.co\/buscador-eventos\/BoletinEpidemiologico\/2023_Bolet%C3%ADn_epidemiologico_semana_27.pdf"},{"key":"150347","doi-asserted-by":"crossref","unstructured":"6. Mora-Obando D, Pla D, Lomonte B, Guerrero-Vargas JA, Ayerbe S, Calvete JJ. Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms. PLoS Negl Trop Dis. 2021;15:1-36. https:\/\/doi.org\/10.1371\/journal.pntd.0009073","DOI":"10.1371\/journal.pntd.0009073"},{"key":"150348","doi-asserted-by":"crossref","unstructured":"7. Nascimento TP, Vilhena Silva-Neto A, Baia-da-Silva DC, Da Silva Balieiro PC, Baleiro AADS, Sachett J, et al. Pregnancy outcomes after snakebite envenomations: A retrospective cohort in the Brazilian Amazonia. PLoS Negl Trop Dis. 2022;16:e0010963. https:\/\/doi.org\/10.1371\/journal.pntd.0010963","DOI":"10.1371\/journal.pntd.0010963"},{"key":"150349","doi-asserted-by":"crossref","unstructured":"8. Wood D. Clinical risk factors associated with poor outcomes in snake envenoming: A narrative review. Toxins. 2023;15:675. https:\/\/doi.org\/10.3390\/toxins15120675","DOI":"10.3390\/toxins15120675"},{"key":"150350","doi-asserted-by":"crossref","unstructured":"9. Sam K, Khan M, Peerally S, Kumar P, Rao P. Snake-bite envenomation: A comprehensive evaluation of severity, treatment, and outcome in a tertiary care South Indian Hospital. Int J Emerg Med. 2008;5:1-9.","DOI":"10.5580\/11c0"},{"key":"150351","doi-asserted-by":"crossref","unstructured":"10. Fai KN, Moustafa H, Esso L, Boum Y. Case 1-2024: A 25-year-old pregnant woman with bleeding after a snakebite. N Engl J Med. 2024;390:166-73. https:\/\/doi.org\/10.1056\/NEJMcpc2301033","DOI":"10.1056\/NEJMcpc2301033"},{"key":"150352","doi-asserted-by":"crossref","unstructured":"11. Langley RL. Snakebite during pregnancy: A literature review. Wilderness Environ Med. 2010;21:54-60. https:\/\/doi.org\/10.1016\/j.wem.2009.12.025","DOI":"10.1016\/j.wem.2009.12.025"},{"key":"150353","doi-asserted-by":"crossref","unstructured":"12. Roa I, Smok C, Prieto R. Placenta: anatom\u00eda e histolog\u00eda comparada. Int J Morphol. 2012;30:1490-6.","DOI":"10.4067\/S0717-95022012000400036"},{"key":"150354","doi-asserted-by":"crossref","unstructured":"13. Hatakeyama DM, Jorge Tasima L, Da Costa Galizio N, Serino-Silva C, Fabri Bittencourt Rodrigues C, Sant\u2019Anna SS, et al. From birth to adulthood: An analysis of the Brazilian lancehead (Bothrops moojeni) venom at different life stages. PLoS ONE. 2021;16:e0253050. https:\/\/doi.org\/10.1371\/journal.pone.0253050","DOI":"10.1371\/journal.pone.0253050"},{"key":"150355","unstructured":"14. Saavedra-Orozco H, M\u00e9ndez-Rodr\u00edguez R, Rojas-Su\u00e1rez J, Castro-Reyes E. Accidente of\u00eddico y embarazo gemelar. Rev Cienc Biomed. 2012;3:333-8."}],"container-title":["Biom\u00e9dica"],"original-title":[],"link":[{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7595\/5753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7595\/5855","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7595\/5753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:45:46Z","timestamp":1773265546000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/view\/7595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,8,11]]}},"URL":"https:\/\/doi.org\/10.7705\/biomedica.7595","relation":{},"ISSN":["2590-7379","0120-4157"],"issn-type":[{"value":"2590-7379","type":"electronic"},{"value":"0120-4157","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2025-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer Review"}},{"value":"Instituto Nacional de Salud","name":"publisher","label":"This article is maintained by"},{"value":"Biomedica","name":"journaltitle","label":"Journal Title"},{"value":"Presentaci\u00f3n de caso","name":"content_type","label":"Content Type"}]}}