{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:00:06Z","timestamp":1790834406001,"version":"4.1.0"},"reference-count":34,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"3","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. La tuberculosis es la principal causa de muerte en los pacientes con infecci\u00f3n por el virus de la inmunodeficiencia humana. La coinfecci\u00f3n de Mycobacterium tuberculosis y HIV es muy frecuente.Objetivo. Establecer la prevalencia de la infecci\u00f3n por HIV en pacientes hospitalizados con tuberculosis, y determinar sus caracter\u00edsticas y desenlaces.Materiales y m\u00e9todos. Se realiz\u00f3 un estudio retrospectivo, de corte transversal, en pacientes con tuberculosis \u2013pulmonar o extrapulmonar\u2013 y coinfecci\u00f3n por HIV, hospitalizados en una instituci\u00f3n de referencia de Bogot\u00e1 entre el 2019 y el 2021. Resultados. En el grupo de los 102 pacientes con tuberculosis, la prevalencia de infecci\u00f3n por HIV fue del 52,3% (54). Entre estos 54, 24 pacientes (44,4%) tuvieron confirmaci\u00f3n microbiol\u00f3gica o histopatol\u00f3gica de la tuberculosis y, 19 (35,2 %), infecci\u00f3n por VIH de novo. En los 54 coinfectados, la mediana de la edad fue de 38 a\u00f1os (RIC: 29-42). El 79,6 % (43\/54) fueron hombres. La mediana del n\u00famero de linfocitos T CD4+ fue de 59 c\u00e9lulas\/\u03bcl (RIC: 32-120), y el 72,2 % (39\/54) ten\u00eda menos de 200 c\u00e9lulas\/\u03bcl. El 31,4 % (17\/54) de los pacientes con antecedente de infecci\u00f3n por HIV recib\u00eda terapia antirretroviral. En cuanto a la forma cl\u00ednica, la tuberculosis fue pulmonar en el 51,9 % (28\/54) y extrapulmonar en el 48,1 % (26\/54) de los pacientes. La tuberculosis extrapulmonar fue men\u00edngea (29,6 %), miliar (12,9 %), pleural (3,7 %) y peritoneal (3,7 %). Hubo 33,3 % de mortalidad intrahospitalaria, asociada con el n\u00famero de linfocitos T CD4+ (p &lt; 0,05), el diagn\u00f3stico de novo de HIV (p &lt; 0,04) y la presencia de tuberculosis men\u00edngea (p &lt; 0,03).Conclusi\u00f3n. La coinfecci\u00f3n de Mycobacterium tuberculosis y HIV es frecuente y se relaciona con una inmunosupresi\u00f3n avanzada, por lo que debe hacerse una b\u00fasqueda activa de la infecci\u00f3n con HIV en estos casos. La tuberculosis men\u00edngea fue la forma extrapulmonar m\u00e1s frecuente y se asoci\u00f3 con mortalidad.<\/jats:p>","DOI":"10.7705\/biomedica.7664","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T18:50:07Z","timestamp":1755283807000},"page":"423-435","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Prevalencia y caracterizaci\u00f3n de la coinfecci\u00f3n por el virus de la inmunodeficiencia humana en pacientes hospitalizados con tuberculosis en un hospital de referencia de Bogot\u00e1","Prevalence and characterization of human immunodeficiency virus coinfection in patients hospitalized with tuberculosis in a reference hospital in Bogot\u00e1"],"prefix":"10.7705","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-1157","authenticated-orcid":false,"given":"Gean Carlo","family":"Puentes-Ariza","sequence":"first","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogot\u00e1, D. C., Colombia"},{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogot\u00e1, D. C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4593-3125","authenticated-orcid":false,"given":"Sugeich","family":"Mel\u00e9ndez-Rhenals","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogot\u00e1, D. C., Colombia; Servicio de Medicina Interna, Hospital Universitario Nacional de Colombia, Corporaci\u00f3n Salud UN, Bogot\u00e1, D.C., Colombia"},{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogot\u00e1, D. C., Colombia; Servicio de Medicina Interna, Hospital Universitario Nacional de Colombia, Corporaci\u00f3n Salud UN, Bogot\u00e1, D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-2339","authenticated-orcid":false,"given":"Laura Cristina","family":"Nocua-B\u00e1ez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogot\u00e1, D. C., Colombia"},{"name":"Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogot\u00e1, D. C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4690-9055","authenticated-orcid":false,"given":"Hugo","family":"P\u00e1ez-Ardila","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda, Hospital Sim\u00f3n Bol\u00edvar, Bogot\u00e1, D.C., Colombia"},{"name":"Servicio de Infectolog\u00eda, Hospital Sim\u00f3n Bol\u00edvar, Bogot\u00e1, D.C., Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"150859","doi-asserted-by":"crossref","unstructured":"1. Murray CJL, Ortblad KF, Guinovart C, Lim SS, Wolock TM, Roberts DA, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:1005-70. https:\/\/doi.org\/10.1016\/S0140-6736(14)60844-8","DOI":"10.1016\/S0140-6736(14)60844-8"},{"key":"150860","doi-asserted-by":"crossref","unstructured":"2. Deeks SG, Overbaugh J, Phillips A, Buchbinder S. HIV infection. Nat Rev Dis Primers. 2015;1:15035. https:\/\/doi.org\/10.1038\/nrdp.2015.35","DOI":"10.1038\/nrdp.2015.35"},{"key":"150861","doi-asserted-by":"crossref","unstructured":"3. Pawlowski A, Jansson M, Sk\u00f6ld M, Rottenberg ME, K\u00e4llenius G. Tuberculosis and HIV coinfection. PLoS Pathog. 2012;8:1002464. https:\/\/doi.org\/10.1371\/journal.ppat.1002464","DOI":"10.1371\/journal.ppat.1002464"},{"key":"150862","unstructured":"4. World Health Organization (WHO). Global tuberculosis report 2024. Geneva: World Health Organization; 2024. Fecha de consulta: 18 de febrero de 2025. Disponible en: https:\/\/iris.who.int\/bitstream\/handle\/10665\/379339\/9789240101531-eng.pdf?sequence=1"},{"key":"150863","doi-asserted-by":"crossref","unstructured":"5. Letang E, Ellis J, Naidoo K, Casas EC, S\u00e1nchez P, Hassan-Moosa R, et al. Tuberculosis-HIV co-infection: Progress and challenges after two decades of global antiretroviral treatment roll-out. Arch Bronconeumol. 2020;56:446-54. https:\/\/doi.org\/10.1016\/j.arbr.2019.11.013","DOI":"10.1016\/j.arbres.2019.11.015"},{"key":"150864","doi-asserted-by":"crossref","unstructured":"6. Gray JM, Cohn DL. Tuberculosis and HIV coinfection. Semin Respir Crit Care Med. 2013;34:32-43. https:\/\/doi.org\/10.1055\/s-0032-1333469","DOI":"10.1055\/s-0032-1333469"},{"key":"150865","doi-asserted-by":"crossref","unstructured":"7. Edge CL, King EJ, Dolan K, McKee M. Prisoners co-infected with tuberculosis and HIV: A systematic review. J Int AIDS Soc. 2016;19:20960. https:\/\/doi.org\/10.7448\/IAS.19.1.20960","DOI":"10.7448\/IAS.19.1.20960"},{"key":"150866","doi-asserted-by":"crossref","unstructured":"8. Bell LCK, Noursadeghi M. Pathogenesis of HIV-1 and Mycobacterium tuberculosis coinfection. Nat Rev Microbiol. 2018;16:80-90. https:\/\/doi.org\/10.1038\/nrmicro.2017.128","DOI":"10.1038\/nrmicro.2017.128"},{"key":"150867","doi-asserted-by":"crossref","unstructured":"9. Mesfin YM, Hailemariam D, Biadgilign S, Kibret KT. Association between HIV\/AIDS and multi-drug resistance tuberculosis: A systematic review and meta-analysis. PLoS ONE. 2013;8:e82235. https:\/\/doi.org\/10.1371\/journal.pone.0082235","DOI":"10.1371\/journal.pone.0082235"},{"key":"150868","doi-asserted-by":"crossref","unstructured":"10. Rockwood N, Wilkinson RJ. Understanding and intervening in HIV-associated tuberculosis. Clin Med (Lond). 2015;15(Suppl.6):S43-9. https:\/\/doi.org\/10.7861\/clinmedicine.15-6-s43","DOI":"10.7861\/clinmedicine.15-6-s43"},{"key":"150869","unstructured":"11. Fadul-P\u00e9rez S. Protocolo de Vigilancia de Tuberculosis. Instituto Nacional de Salud. 2022. p.1-33. Fecha de consulta: 13 de junio de 2024. Disponible en: https:\/\/www.ins.gov.co\/buscador-eventos\/Lineamientos\/Pro_Tuberculosis%202022.pdf"},{"key":"150870","unstructured":"12. Pan American Health Organization. Factsheet 2022: TB\/HIV co-infection in the Americas. Washington D. C.: PAHO\/WHO; 2022. Fecha de consulta: 18 de febrero de 2025. Disponible en: https:\/\/www.paho.org\/sites\/default\/files\/2023-08\/2022-cde-factsheet-tb-HIVamericas.pdf"},{"key":"150871","unstructured":"13. Ministerio de Salud y Protecci\u00f3n Social. Lineamiento t\u00e9cnico operativo del Programa Nacional de Tuberculosis. Direcci\u00f3n de Promoci\u00f3n y Prevenci\u00f3n. Subdirecci\u00f3n de Enfermedades Transmisibles. Bogot\u00e1, D.C.; 2020. Fecha de consulta: 13 de junio de 2024. Disponible en: https:\/\/www.minsalud.gov.co\/Normatividad_Nuevo\/Resoluci%C3%B3n%20No.%20227%20de%202020.pdf"},{"key":"150872","unstructured":"14. StataCorp. Stata Statistical Software: Release 15. College Station, Texas: StataCorp; 2017."},{"key":"150873","unstructured":"15. Ministerio de Salud. Resoluci\u00f3n n\u00famero 8430 de 1993 por la cual se establecen las normas cient\u00edficas, t\u00e9cnicas y administrativas para la investigaci\u00f3n en salud. 1993. Fecha de consulta: 13 de junio de 2024. Disponible en: https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/DE\/DIJ\/RESOLUCION-8430-DE-1993.pdf"},{"key":"150874","unstructured":"16. Frieden TR, Harold Jaffe DW, Moran JS, Leahy MA, Martinroe JC, Spriggs SR, et al. Revised surveillance case definition for HIV Infection \u2014 United States, 2014. MMWR Recomm Rep. 2014;63:1-13."},{"key":"150875","unstructured":"17. Joint United Nations Programme on HIV\/AIDS (UNAIDS). In danger: UNAIDS Global AIDS Update 2022. Geneva: UNAIDS; 2022. Fecha de consulta: 13 de junio de 2024. Disponible en: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/2022-global-aids-update_en.pdf"},{"key":"150876","doi-asserted-by":"crossref","unstructured":"18. Kawatsu L, Uchimura K, Kaneko N, Imahashi M. Epidemiology of coinfection with tuberculosis and HIV in Japan, 2012-2020. West Pac Surveill Response J. 2022;13:1-8. https:\/\/doi.org\/10.5365\/wpsar.2022.13.1.896","DOI":"10.5365\/wpsar.2022.13.1.896"},{"key":"150877","doi-asserted-by":"crossref","unstructured":"19. Zohar M, Moshe L, Daniel C, Noa C, Itamar G. HIV prevalence in the Israeli tuberculosis cohort, 1999-2011. BMC Public Health. 2014;14:1090. https:\/\/doi.org\/10.1186\/1471-2458-14-1090","DOI":"10.1186\/1471-2458-14-1090"},{"key":"150878","unstructured":"20. WHO Regional Office for Europe, European Centre for Disease Prevention and Control. HIV\/AIDS surveillance in Europe 2024-2023 data. Copenhagen: WHO Regional Office for Europe; 2024. Fecha de consulta: 18 de febrero de 2025. Disponible en: https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/HIV_Surveillance_Report_2024.pdf"},{"key":"150879","unstructured":"21. Cuenta de Alto Costo (CAC). Situaci\u00f3n del HIV en Colombia 2024; Bogot\u00e1, D. C.: Fondo Colombiano de Enfermedades de Alto Costo; 2025. Fecha de consulta: 18 de febrero de 2025. Disponible en: https:\/\/cuentadealtocosto.org\/publicaciones\/situacion-del-HIV-encolombia-2024\/"},{"key":"150880","unstructured":"22. Cort\u00e9s JA, Hidalgo P, Rey DL, Parra GA, Guti\u00e9rrez IF. Tuberculosis en pacientes con infecci\u00f3n por VIH en el Hospital Universitario de San Ignacio, 2002-2006. Infectio. 2007;11:16-22."},{"key":"150881","doi-asserted-by":"crossref","unstructured":"23. Ruiz L, Maya MA, Rueda ZV, L\u00f3pez L, V\u00e9lez LA. Current characteristics of tuberculosis and human immunodeficiency virus co-infection in a cohort of hospitalized patients in Medell\u00edn, Colombia. Biom\u00e9dica. 2018;38:59-67. https:\/\/doi.org\/10.7705\/biomedica.v38i3.3862","DOI":"10.7705\/biomedica.v38i3.3862"},{"key":"150882","doi-asserted-by":"crossref","unstructured":"24. Tancredi MV, Sakabe S, Waldman EA. Mortality and survival of tuberculosis coinfected patients living with AIDS in S\u00e3o Paulo, Brazil: A 12-year cohort study. BMC Infect Dis. 2022;22:223. https:\/\/doi.org\/10.1186\/s12879-022-07232-6","DOI":"10.1186\/s12879-022-07232-6"},{"key":"150883","doi-asserted-by":"crossref","unstructured":"25. Sanhueza-Sanzana C, Kerr L, Kendall C. Mortality from AIDS and tuberculosis-HIV coinfection in the Chilean AIDS Cohort of 2000-2017. Cad Sa\u00fade P\u00fablica. 2021;37:e00212920. https:\/\/doi.org\/10.1590\/0102-311X00212920","DOI":"10.1590\/0102-311x00212920"},{"key":"150884","doi-asserted-by":"crossref","unstructured":"26. Garc\u00eda I, Merch\u00e1n A, Chaparro PE, L\u00f3pez LE. Panorama de la coinfecci\u00f3n tuberculosis\/HIV en Bogot\u00e1, 2001. Biom\u00e9dica. 2004;24(Supl.1):132-7. https:\/\/doi.org\/10.7705\/biomedica.v24iSupp1.1312","DOI":"10.7705\/biomedica.v24iSupp1.1312"},{"key":"150885","doi-asserted-by":"crossref","unstructured":"27. Mont\u00fafar Andrade FE, Villa Franco P, Mont\u00fafar Pantoja MC, Zuleta Tob\u00f3n JJ, P\u00e9rez Jaramillo LE, Monsalve Valencia MA, et al. Coinfecci\u00f3n por virus de inmunodeficiencia humana y micobacterias en un hospital universitario de alta complejidad en Colombia. Infectio. 2016;20:158-64. http:\/\/doi.org\/10.1016\/j.infect.2015.05.004","DOI":"10.1016\/j.infect.2015.05.006"},{"key":"150886","unstructured":"28. Joint United Nations Programme on HIV\/AIDS (UNAIDS). Global HIV & AIDS statistics \u2014 Fact sheet 2024. Geneva: UNAIDS; 2024. Fecha de consulta: 19 de febrero de 2025. Disponible en: https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/UNAIDS_FactSheet_en.pdf"},{"key":"150887","doi-asserted-by":"crossref","unstructured":"29. de Vries G, van de Berg S, van Dam A, Hasanova S, Pareek M, van der Werf MJ, et al. Collaborative tuberculosis\/HIV activities in the European Region. ERJ Open Res. 2021;7:00721-2020. https:\/\/doi.org\/10.1183\/23120541.00721-2020","DOI":"10.1183\/23120541.00721-2020"},{"key":"150888","doi-asserted-by":"crossref","unstructured":"30. Abay SM, Deribe K, Reda AA, Biadgilign S, Datiko D, Assefa T, et al. The Effect of early initiation of antiretroviral therapy in TB\/HIV-coinfected patients: A systematic review and meta-analysis. J Int Assoc Provid AIDS Care. 2015;14:560-70. https:\/\/doi.org\/10.1177\/2325957415599210","DOI":"10.1177\/2325957415599210"},{"key":"150889","doi-asserted-by":"crossref","unstructured":"31. Plata-Casas L, Guti\u00e9rrez-Lesmes O, Herr\u00e1n-Falla O. Infecci\u00f3n concomitante por tuberculosis y el virus de la inmunodeficiencia humana: situaci\u00f3n epidemiol\u00f3gica e departamento del Meta, 2010-2015. Biom\u00e9dica. 2018;38:68-79. https:\/\/doi.org\/10.7705\/biomedica.v38i3.3930","DOI":"10.7705\/biomedica.v38i3.3930"},{"key":"150890","doi-asserted-by":"crossref","unstructured":"32. Rindi L. Rapid molecular diagnosis of extra-pulmonary tuberculosis by Xpert\/RIF ultra. Front Microbiol. 2022;13:817661. https:\/\/doi.org\/10.3389\/fmicb.2022.817661","DOI":"10.3389\/fmicb.2022.817661"},{"key":"150891","doi-asserted-by":"crossref","unstructured":"33. Seddon JA, Tugume L, Solomons R, Prasad K, Bahr NC; Tuberculous Meningitis International Research Consortium. The current global situation for tuberculous meningitis: Epidemiology, diagnostics, treatment and outcomes. Wellcome Open Res. 2019;4:167. https:\/\/doi.org\/10.12688\/wellcomeopenres.15535.1","DOI":"10.12688\/wellcomeopenres.15535.1"},{"key":"150892","unstructured":"34. Cecchini D, Ambrosioni J, Brezzo C, Corti M, Rybko A, P\u00e9rez M, et al. Tuberculous meningitis in HIV-infected and non-infected patients: Comparison of cerebrospinal fluid findings. Int J Tuberc Lung Dis. 2009;13:269-71."}],"container-title":["Biom\u00e9dica"],"original-title":[],"link":[{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7664\/5749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7664\/5856","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/download\/7664\/5749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:45:39Z","timestamp":1773265539000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistabiomedica.org\/index.php\/biomedica\/article\/view\/7664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,8,11]]}},"URL":"https:\/\/doi.org\/10.7705\/biomedica.7664","relation":{},"ISSN":["2590-7379","0120-4157"],"issn-type":[{"value":"2590-7379","type":"electronic"},{"value":"0120-4157","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2025-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer Reviewed","group":{"name":"peer_review","label":"Peer Review"}},{"value":"Instituto Nacional de Salud","name":"publisher","label":"This article is maintained by"},{"value":"Biomedica","name":"journaltitle","label":"Journal Title"},{"value":"Art\u00edculos originales","name":"content_type","label":"Content Type"}]}}