{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:47:26Z","timestamp":1773323246193,"version":"3.50.1"},"reference-count":14,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"4","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Prompt diagnosis and treatment of spinal tuberculosis are key in preventing its neurological and physical sequelae. This affection, also known as Pott\u2019s disease, should be considered a differential diagnosis in patients presenting with unexplained back pain that can lead to neurological symptoms and eventually paraplegia.Mycobacterium tuberculosis, the etiological agent of tuberculosis, spreads from the lungs to the spine via venous or arterial pathways, causing lesions apparent upon imaging. Radiological findings include osseous destruction, disk collapse, abscess formation, and spinal deformity. While magnetic resonance is considered the most sensitive and specific imaging modality to establish a diagnosis, plain radiographs and computed tomography can provide useful information.This manuscript discusses three Colombian cases of spinal tuberculosis with the goal of increasing familiarity regarding the pathophysiology, clinical and radiological manifestations, and differential diagnosis of this rare but potentially devastating disease.<\/jats:p>","DOI":"10.7705\/biomedica.7685","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T21:45:14Z","timestamp":1758836714000},"page":"511-520","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Spinal tuberculosis, pathophysiology and radiological presentation, three case reports","Tuberculosis vertebral, fisiopatolog\u00eda y presentaci\u00f3n radiol\u00f3gica, reporte de tres casos"],"prefix":"10.7705","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8841-1120","authenticated-orcid":false,"given":"Vanessa M.S.","family":"Ross","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-8132","authenticated-orcid":false,"given":"Bibiana","family":"Pinz\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Radiolog\u00eda, Hospital Universitario Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, D. C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Mar\u00eda","family":"Palacios-Ortiz","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda y Laboratorios Hospital Universitario, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-3618","authenticated-orcid":false,"given":"Zandra","family":"De La Rosa-Noriega","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda y Laboratorios Hospital Universitario, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, D.C., Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0208-2145","authenticated-orcid":false,"given":"Jana Abi","family":"Rafeh","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2565-808X","authenticated-orcid":false,"given":"Leonardo F.","family":"Jurado","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada; Departamento de Patolog\u00eda y Laboratorios Hospital Universitario, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, D.C., Colombia; Department of Pathology, McGill University Health Centre, McGill International TB Centre, Meakins-Christie Laboratories, McGill University, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"153383","unstructured":"World Health Organization. Global tuberculosis report 2024. Geneva: World Health Organization; 2024. Accessed: August 26, 2024. Available at: https:\/\/iris.who.int\/bitstream\/handle\/10665\/379339\/9789240101531-eng.pdf?sequence=1"},{"key":"153384","unstructured":"Center for Disease Control and Prevention. Clinical overview of tuberculosis disease. Accessed: August 26, 2024. Available at: https:\/\/www.cdc.gov\/tb\/hcp\/clinical-overview\/tuberculosis-disease.html"},{"key":"153385","doi-asserted-by":"crossref","unstructured":"Sharma SK, Mohan A, Kohli M. Extrapulmonary tuberculosis. Expert Rev Respir Med. 2021;15:931-48. https:\/\/doi.org\/10.1080\/17476348.2021.1927718","DOI":"10.1080\/17476348.2021.1927718"},{"key":"153386","doi-asserted-by":"crossref","unstructured":"Garg RK, Somvanshi DS. Spinal tuberculosis: A review. J Spinal Cord Med. 2011;34:440-54. https:\/\/doi.org\/10.1179\/2045772311Y.0000000023","DOI":"10.1179\/2045772311Y.0000000023"},{"key":"153387","doi-asserted-by":"crossref","unstructured":"Stout J. Bone and joint tuberculosis. UpToDate. 2022. Accessed: August 26, 2024. Available at: https:\/\/www.uptodate.com\/contents\/search","DOI":"10.1097\/01.ASM.0000842064.74995.09"},{"key":"153388","unstructured":"World Health Organization. Global lists of high burden countries for tuberculosis (TB), TB\/HIV and multidrug\/rifampicin-resistant TB (MDR\/RR-TB), 2021-2025: Background document. Geneva: World Health Organization; 2021. Accessed: August 26, 2024. Available at: https:\/\/iris.who.int\/bitstream\/handle\/10665\/341980\/9789240029439-eng.pdf"},{"key":"153389","unstructured":"World Bank: Incidence of tuberculosis. Accessed: August 26, 2024. Available at: https:\/\/data.worldbank.org\/indicator\/SH.TBS.INCD"},{"key":"153390","doi-asserted-by":"crossref","unstructured":"Sternbach G. Percivall Pott: Tuberculous spondylitis. J Emerg Med. 1996;14:79-83. https:\/\/doi.org\/10.1016\/0736-4679(95)02053-5","DOI":"10.1016\/0736-4679(95)02053-5"},{"key":"153391","doi-asserted-by":"crossref","unstructured":"Glassman I, Nguyen KH, Giess J, Alcantara C, Booth M, Venketaraman V. Pathogenesis, diagnostic challenges, and risk factors of Pott\u2019s disease. Clin Pract. 2023;13:155-65. https:\/\/doi.org\/10.3390\/clinpract13010014","DOI":"10.3390\/clinpract13010014"},{"key":"153392","doi-asserted-by":"crossref","unstructured":"Semionov A, Lebel K, Diouf A, Pressacco J. Tuberculosis: A head-to-toe radiological review. Open J Radiol. 2022;12:207-21. https:\/\/doi.org\/10.4236\/ojrad.2022.124021","DOI":"10.4236\/ojrad.2022.124021"},{"key":"153393","doi-asserted-by":"crossref","unstructured":"Manika K, Kipourou M, Georga S, Faniadou E, Pilianidis G, Arsos G, et al. 18F-FDG PET\/CT contribution to tuberculous vertebral osteomyelitis diagnosis: a case report. 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