{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:16:10Z","timestamp":1783052170354,"version":"3.54.6"},"reference-count":59,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. La recombinaci\u00f3n es un mecanismo que evita la acumulaci\u00f3n de mutaciones nocivas. Para que se d\u00e9 entre diferentes sublinajes de un mismo virus, se requiere cocirculaci\u00f3n y coinfecci\u00f3n en un mismo hu\u00e9sped. Mediante NGS (next-generation sequencing) se han podido caracterizar linajes recombinantes de la variante \u00f3micron.Objetivo. Describir c\u00f3mo la recombinaci\u00f3n viral en linajes de \u00f3micron le ha conferido caracter\u00edsticas importantes para su prevalencia sobre otros linajes.Materiales y m\u00e9todos. Se caracterizaron 338 genomas de linajes recombinantes de muestras positivas de SARS-CoV-2 analizadas por el Laboratorio Departamental de Salud P\u00fablica de Antioquia, entre el 9 de noviembre del 2022 y el 5 de noviembre del 2023. Los genomas fueron obtenidos mediante la tecnolog\u00eda de secuenciaci\u00f3n de Oxford Nanopore\u2122. Por medio de an\u00e1lisis filogen\u00e9ticos se identificaron diferentes sublinajes recombinantes de \u00f3micron. Predictores permitieron la identificaci\u00f3n de regiones del genoma de SARS-CoV-2 que hab\u00edan sido producto de eventos de recombinaci\u00f3n. Resultados. Se identificaron 26 linajes recombinantes de \u00f3micron en los que se encontraron cambios de amino\u00e1cidos de gran importancia, involucrados en la evasi\u00f3n de la respuesta inmunitaria, infectividad y replicaci\u00f3n viral. Tambi\u00e9n se identific\u00f3 la mutaci\u00f3n F456L, presente en el 55 % de los genomas de XBB.1.5.72, que sirve como biomarcador de reconocimiento de este sublinaje. Los an\u00e1lisis con predictores permitieron la identificaci\u00f3n de los probables linajes parentales de algunos genomas recombinantes como XBB.1.5 y XBB.1.5.77.Conclusi\u00f3n. La circulaci\u00f3n de sublinajes recombinantes de \u00f3micron muestran cambios importantes que impactan la biolog\u00eda de estos y han alterado los factores de infecci\u00f3n y virulencia.<\/jats:p>","DOI":"10.7705\/biomedica.7698","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:11:52Z","timestamp":1782321112000},"page":"228-245","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Caracterizaci\u00f3n de genomas recombinantes de la variante \u00f3micron del SARS-CoV-2 entre el 2022 y el 2023 en el departamento de Antioquia, Colombia","Characterization of recombinant genomes of the omicron variant of SARS-CoV-2 between 2022 and 2023 in the department of Antioquia, Colombia"],"prefix":"10.7705","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-1832","authenticated-orcid":false,"given":"Cristian Arbey","family":"Velarde","sequence":"first","affiliation":[{"name":"Laboratorio Departamental de Salud P\u00fablica de Antioquia, Secretar\u00eda Seccional de Salud y Protecci\u00f3n Social de Antioquia, Gobernaci\u00f3n de Antioquia, Medell\u00edn, Colombia"},{"name":"Laboratorio Departamental de Salud P\u00fablica de Antioquia, Secretar\u00eda Seccional de Salud y Protecci\u00f3n Social de Antioquia, Gobernaci\u00f3n de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0165-9568","authenticated-orcid":false,"given":"Leila Cristina","family":"Vega","sequence":"additional","affiliation":[{"name":"Laboratorio Departamental de Salud P\u00fablica de Antioquia, Secretar\u00eda Seccional de Salud y Protecci\u00f3n Social de Antioquia, Gobernaci\u00f3n de Antioquia, Medell\u00edn, Colombia"},{"name":"Laboratorio Departamental de Salud P\u00fablica de Antioquia, Secretar\u00eda Seccional de Salud y Protecci\u00f3n Social de Antioquia, Gobernaci\u00f3n de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-5011","authenticated-orcid":false,"given":"Idabely","family":"Betancur","sequence":"additional","affiliation":[{"name":"Laboratorio Departamental de Salud P\u00fablica de Antioquia, Secretar\u00eda Seccional de Salud y Protecci\u00f3n Social de Antioquia, Gobernaci\u00f3n de Antioquia, Medell\u00edn, Colombia"},{"name":"Laboratorio Departamental de Salud P\u00fablica de Antioquia, Secretar\u00eda Seccional de Salud y Protecci\u00f3n Social de Antioquia, Gobernaci\u00f3n de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"164506","doi-asserted-by":"crossref","unstructured":"Bonnet J, Fraile A, Sacrist\u00e1n S, Malpica JM, Garc\u00eda-Arenal F. 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