{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:16:06Z","timestamp":1783052166465,"version":"3.54.6"},"reference-count":37,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["PPSUS n\u00b0 SUS0024\/2018"],"award-info":[{"award-number":["PPSUS n\u00b0 SUS0024\/2018"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. La estrongiloidiasis puede convertirse en una enfermedad grave en grupos de alto riesgo, como los alcoh\u00f3licos. Sin embargo, pocos estudios eval\u00faan el efecto de esta comorbilidad en la salud de los individuos.Objetivo. Evaluar biomarcadores hematol\u00f3gicos, bioqu\u00edmicos y hep\u00e1ticos y la producci\u00f3n de inmunoglobulina E total en pacientes alcoh\u00f3licos infectados con S. stercoralis. Materiales y m\u00e9todos. Se trata de un estudio de casos y controles con 240 pacientes alcoh\u00f3licos, 60 infectados y 180 no infectados con S. stercoralis. Los biomarcadores sangu\u00edneos se evaluaron mediante m\u00e9todos automatizados, kits comerciales o nefelometr\u00eda. Resultados. Se observ\u00f3 una alta frecuencia de alcoh\u00f3licos con anemia, sin diferencia entre los grupos infectados y los no infectados, 65,0 % (39\/60) y 62,8 % (113\/180), respectivamente. La frecuencia de eosinofilia, 58,3 (35\/60) y 26,1 % (47\/180) y la concentraci\u00f3n total de inmunoglobulina E, 2882 y 1400 UI\/ml, fueron significativamente mayores (p &lt; 0,05) en los individuos infectados con S. stercoralis en comparaci\u00f3n con los no infectados. Los niveles de ALT y AST estuvieron elevados en ambos grupos. Sin embargo, en el grupo infectado se encontraron niveles m\u00e1s bajos de AST, 61,5 \u00b1 38,4 comparado con 84,3 \u00b1 84,6 U\/L en no infectados y una menor frecuencia de individuos con niveles elevados de ALT, 26,7 % (16\/60) comparado con 40,5 % (73\/180) en pacientes infectados. Adem\u00e1s, los niveles de AST fueron mayores en individuos con una carga parasitaria superior a 100 larvas\/g de heces, en comparaci\u00f3n con aquellos con una menor carga parasitaria (90,80 \u00b1 39,9 y 56,42 \u00b1 31,9 U\/L (p &lt; 0,05), respectivamente).Conclusiones: Este estudio demuestra una menor alteraci\u00f3n de las enzimas hep\u00e1ticas en alcoh\u00f3licos infectados con S. stercoralis, lo cual podr\u00eda depender de la carga parasitaria.<\/jats:p>","DOI":"10.7705\/biomedica.7735","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:11:52Z","timestamp":1782321112000},"page":"246-253","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["La infecci\u00f3n por Strongyloides stercoralis altera los niveles de las enzimas hep\u00e1ticas de pacientes alcoh\u00f3licos.","Strongyloides stercoralis infection alters liver enzyme levels in alcoholic patients."],"prefix":"10.7705","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1456-9009","authenticated-orcid":false,"given":"Joelma","family":"Nascimento de Souza","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"},{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-6702","authenticated-orcid":false,"given":"Weslei","family":"Almeida Costa Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"},{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-3223","authenticated-orcid":false,"given":"Alex Bruno","family":"De Souza","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"},{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0477-5092","authenticated-orcid":false,"given":"M\u00e1rcia Cristina","family":"Aquino Teixeira","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"},{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-9884","authenticated-orcid":false,"given":"Neci","family":"Matos Soares","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"},{"name":"Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador, Bahia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"164565","doi-asserted-by":"crossref","unstructured":"Buonfrate D, Bisanzio D, Giorli G, Odermatt P, F\u00fcrst T, Greenaway C, et al. 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