{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:08:35Z","timestamp":1774613315097,"version":"3.50.1"},"reference-count":13,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Leptospirosis, a widespread zoonotic disease prevalent in tropical and subtropical regions, causes over one million cases and about 59,000 deaths annually. It is transmitted through contact with infected animal urine, primarily from rodents, and worsened by poor sanitation and favorable climate. Although in Colombia there was a significant decline in cases from 2018 to 2022, severe forms of the disease, including rare complications like acute pancreatitis, still pose significant health risks.A 49-year-old male presented with symptoms including abdominal pain, jaundice, and severe thrombocytopenia. Despite initial normal tests, leptospirosis was eventually diagnosed after further testing revealed elevated lipase levels and medical imaging confirmed severe pancreatitis. The patient received antibiotics and intensive care, which led to recovery and confirmation of leptospirosis through serology.Leptospirosis can cause severe multi-organ complications, including rare cases of pancreatitis. This case underscores the need for early diagnosis and treatment of leptospirosis to manage such complications effectively. Environmental factors and rodent control are crucial for prevention, emphasizing the importance of comprehensive management and preventive measures.<\/jats:p>","DOI":"10.7705\/biomedica.7771","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:30:47Z","timestamp":1772807447000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Acute pancreatitis due to Leptospira spp.: An uncommon case report of a common zoonosis","Pancreatitis aguda por Leptospira spp.: un informe de caso poco com\u00fan de una zoonosis com\u00fan"],"prefix":"10.7705","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-3146","authenticated-orcid":false,"given":"Juan Pablo","family":"L\u00f3pez","sequence":"first","affiliation":[{"name":"Servicio de Hospitalizaci\u00f3n, Cl\u00ednica Nueva de Cali, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-7739","authenticated-orcid":false,"given":"Carlos Alberto","family":"Salgado","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Cl\u00ednica Nueva de Cali, Cali, Colombia; Programa de Medicina Interna, Pontificia Universidad Javeriana, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1606-8398","authenticated-orcid":false,"given":"Cristhian David","family":"Morales","sequence":"additional","affiliation":[{"name":"Programa de Especializaci\u00f3n en Medicina Forense, Pontificia Universidad Javeriana, Cali, Colombia; Departamento de Salud P\u00fablica, Facultad Salud, Universidad Aut\u00f3noma de Manizales, Manizales, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4444","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"158597","doi-asserted-by":"crossref","unstructured":"Biscornet L, de Comarmond J, Bibi J, Mavingui P, Dellagi K, Tortosa P, et al. An observational study of human leptospirosis in Seychelles. Am J Trop Med Hyg. 2020;103:999-1008. https:\/\/doi.org\/10.4269\/ajtmh.19-0228","DOI":"10.4269\/ajtmh.19-0228"},{"key":"158598","doi-asserted-by":"crossref","unstructured":"Baharom M, Ahmad N, Hod R, Ja\u2019afar MH, Arsad FS, Tangang F, et al. Environmental and occupational factors associated with leptospirosis: A systematic review. Heliyon. 2023;10:e23473. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e23473","DOI":"10.1016\/j.heliyon.2023.e23473"},{"key":"158599","doi-asserted-by":"crossref","unstructured":"Instituto Nacional de Salud. Protocolo de vigilancia en salud p\u00fablica, Leptospirosis. Accessed: November 10, 2024. Available at: https:\/\/www.ins.gov.co\/buscador-eventos\/Lineamientos\/Pro_Leptospirosis%202024.pdf","DOI":"10.33610\/400816ruxhbr"},{"key":"158600","doi-asserted-by":"crossref","unstructured":"Charles JC, Jayarajah U, Subasinghe D. Clinical characteristics and outcomes of patients with leptospirosis complicated with acute pancreatitis: A systematic review. J Int Med Res. 2023;51:3000605231197461. https:\/\/doi.org\/10.1177\/03000605231197461","DOI":"10.1177\/03000605231197461"},{"key":"158601","doi-asserted-by":"crossref","unstructured":"Guechi M, Guenifi W, Gasmi A, Ouyahia A, Rais M, Boukhrissa H, et al. Severe acute pancreatitis associated with Weil\u2019s disease. Middle East J Dig Dis. 2023;15:53-6. https:\/\/doi.org\/10.34172\/mejdd.2023.320","DOI":"10.34172\/mejdd.2023.320"},{"key":"158602","doi-asserted-by":"crossref","unstructured":"Rajapakse S, Rodrigo C, Balaji K, Fernando SD. Atypical manifestations of leptospirosis. Trans R Soc Trop Med Hyg. 2015;109:294-302. https:\/\/doi.org\/10.1093\/trstmh\/trv026","DOI":"10.1093\/trstmh\/trv026"},{"key":"158603","doi-asserted-by":"crossref","unstructured":"Miida S, Maruyama M, Sato T, Nagoya T, Goto R, Isokawa O, et al. Acute pancreatitis as a are complication of leptospirosis: A case report and literature review. J Infect Chemother. 2024;30:552-6. https:\/\/doi.org\/10.1016\/j.jiac.2023.11.027","DOI":"10.1016\/j.jiac.2023.11.027"},{"key":"158604","doi-asserted-by":"crossref","unstructured":"Walkowska J, Zielinska N, Tubbs RS, Podg\u00f3rski M, D\u0142ubek-Ruxer J, Olewnik \u0141. Diagnosis and treatment of acute pancreatitis. Diagnostics (Basel). 2022;12:1974. https:\/\/doi.org\/10.3390\/diagnostics12081974","DOI":"10.3390\/diagnostics12081974"},{"key":"158605","doi-asserted-by":"crossref","unstructured":"Ortiz Morales CM, Girela Baena EL, Olalla Mu\u00f1oz JR, Parlorio de Andr\u00e9s E, L\u00f3pez Corbal\u00e1n JA. Radiology of acute pancreatitis today: The Atlanta classification and the current role of imaging in its diagnosis and treatment. Radiolog\u00eda (English edition). 2019;61:453-66. https:\/\/doi.org\/10.1016\/j.rx.2019.04.001","DOI":"10.1016\/j.rxeng.2019.06.005"},{"key":"158606","doi-asserted-by":"crossref","unstructured":"Kaya E, Dervisoglu A, Eroglu C, Polat C, Sunbul M, Ozkan K. Acute pancreatitis caused by leptospirosis: Report of two cases. World J Gastroenterol. 2005;11:4447-9. https:\/\/doi.org\/10.3748\/wjg.v11.i28.4447","DOI":"10.3748\/wjg.v11.i28.4447"},{"key":"158607","doi-asserted-by":"crossref","unstructured":"Tenner S, Vege SS, Sheth SG, Sauer B, Yang A, Conwell DL, et al. American College of Gastroenterology Guidelines: Management of acute pancreatitis. Am J Gastroenterol. 2024;119:419-37. https:\/\/doi.org\/10.14309\/ajg.0000000000002645","DOI":"10.14309\/ajg.0000000000002645"},{"key":"158608","doi-asserted-by":"crossref","unstructured":"Senosiain Lalastra C, Tav\u00edo Hern\u00e1ndez E, Moreira Vicente V, Maroto Castellanos M, Garc\u00eda S\u00e1nchez MC, Aicart Ramos M, et al. Pancreatitis aguda por hipertrigliceridemia. Gastroenterol Hepatol. 2013;36:274-9. https:\/\/doi.org\/10.1016\/j.gastrohep.2012.11.006","DOI":"10.1016\/j.gastrohep.2012.11.006"},{"key":"158609","doi-asserted-by":"crossref","unstructured":"Sykes JE, Haake DA, Gamage CD, Mills WZ, Nally JE. A global one health perspective on leptospirosis in humans and animals. 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