{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:31:32Z","timestamp":1793878292074,"version":"4.7.0"},"reference-count":61,"publisher":"Instituto Nacional de Salud (Colombia)","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["revistabiomedica.org"],"crossmark-restriction":false},"short-container-title":["Biomed."],"abstract":"<jats:p>Introducci\u00f3n. El coronavirus del SARS-CoV-2 ha sido una de las pandemias m\u00e1s significativas de la era moderna. Es un coronavirus con alta tasa de mutaci\u00f3n, lo que genera variantes con cambios en la prote\u00edna esp\u00edcula (spike), que dificulta su contenci\u00f3n. La vigilancia gen\u00f3mica es crucial para adaptar estrategias de salud p\u00fablica y vacunaci\u00f3n, especialmente en los pa\u00edses de ingresos bajos y medios, donde el impacto ha sido considerable.Objetivo. Identificar variantes virales y sus presentaciones cl\u00ednicas en una cohorte prospectiva de pacientes hospitalizados con infecci\u00f3n por SARS-CoV-2 entre octubre de 2021 y febrero de 2023.Materiales y m\u00e9todos. Se recopilaron datos demogr\u00e1ficos, historial m\u00e9dico, estado de vacunaci\u00f3n y progresi\u00f3n cl\u00ednica. Se hizo secuenciaci\u00f3n del genoma viral en muestras de hisopados nasales confirmadas con la prueba de reacci\u00f3n en cadena de la polimerasa en tiempo real con transcripci\u00f3n inversa para clasificar las cepas y detectar variantes.Resultados. De 63 muestras positivas para SARS-CoV-2, la variante predominante fue \u00f3micron (84 %), seguida de la delta (14 %). La variante delta present\u00f3 la mayor proporci\u00f3n de enfermedad grave (100 % casos cr\u00edticos) comparada con \u00f3micron (30 % casos cr\u00edticos). Se identificaron mutaciones en la prote\u00edna esp\u00edcula en cuatro categor\u00edas (A-D), junto con mutaciones espec\u00edficas del gen S.Conclusi\u00f3n. Los patrones de mutaci\u00f3n observados coinciden con los reportes globales, con mayor seriedad cl\u00ednica en la variante delta. Se identificaron mutaciones en la prote\u00edna espiga que confieren propiedades distintivas al virus. Estos hallazgos resaltan la necesidad de la vigilancia gen\u00f3mica continua para comprender la din\u00e1mica de la infecci\u00f3n y orientar las estrategias de salud p\u00fablica.<\/jats:p>","DOI":"10.7705\/biomedica.7783","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:30:47Z","timestamp":1772807447000},"page":"48-70","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Vigilancia gen\u00f3mica de variantes del coronavirus del SARS-CoV-2 en pacientes hospitalizados: una cohorte del \u00e1rea metropolitana del valle de Aburr\u00e1, Colombia","Genomic surveillance of SARS-CoV-2 variants in hospitalized patients: a cohort study from the metropolitan area of valle de Aburr\u00e1, Colombia"],"prefix":"10.7705","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9738-0489","authenticated-orcid":false,"given":"Olga H.","family":"Hern\u00e1ndez-Ortiz","sequence":"first","affiliation":[{"name":"Laboratorio Gen\u00f3mico One Health, Universidad Nacional de Colombia, Medell\u00edn, Colombia; Cuidados Intensivos, Grupo Quir\u00f3nsalud, Cl\u00ednica Medell\u00edn, Medell\u00edn, Colombia; Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-3697","authenticated-orcid":false,"given":"Laura","family":"P\u00e9rez-Restrepo","sequence":"additional","affiliation":[{"name":"Laboratorio Gen\u00f3mico One Health, Universidad Nacional de Colombia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2830-908X","authenticated-orcid":false,"given":"Jaime","family":"\u00dasuga","sequence":"additional","affiliation":[{"name":"Laboratorio Gen\u00f3mico One Health, Universidad Nacional de Colombia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5125-3011","authenticated-orcid":false,"given":"Melissa","family":"Moreno","sequence":"additional","affiliation":[{"name":"Laboratorio Gen\u00f3mico One Health, Universidad Nacional de Colombia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5725-5813","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Cuidados Intensivos, Grupo Quir\u00f3nsalud, Cl\u00ednica Medell\u00edn, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0246-5393","authenticated-orcid":false,"given":"Juan","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Cuidados Intensivos, Hospital General de Medell\u00edn, Medell\u00edn, Colombia;\u00a0Cuidados Intensivos, Grupo Auna, Cl\u00ednica Las Am\u00e9ricas, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-7456","authenticated-orcid":false,"given":"Jorge","family":"Sar\u00e1","sequence":"additional","affiliation":[{"name":"Palm Medical Center, Avon Park, Florida, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0705-6579","authenticated-orcid":false,"given":"Francisco","family":"Molina-Saldarriaga","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universitaria Bolivariana, Universidad Pontificia Bolivariana, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-5367","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"Jaimes","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7474-6150","authenticated-orcid":false,"given":"Jorge","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-9947","authenticated-orcid":false,"given":"Juan P.","family":"Hern\u00e1ndez-Ortiz","sequence":"additional","affiliation":[{"name":"Laboratorio Gen\u00f3mico One Health, Universidad Nacional de Colombia, Medell\u00edn, Colombia; Facultad de Minas, Universidad Nacional de Colombia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"158801","unstructured":"Organizaci\u00f3n Mundial de la Salud. 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