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In vivo, ivermectin was administered orally to mice at a single 0.2 mg\/kg dose at 2 (group I), 7 (group II), or 15 days (group III) post-infection. Efficacy was evaluated through brain larval counts and histopathological examination of liver and brain.Results. In vitro, ivermectin at concentrations of 10 \u03bcg\/ml and 100 \u03bcg\/ml inhibited larval migration by 8.5% and 87%, respectively. SEM showed cuticular damage after 24 and 48 hours with 100 \u03bcg\/ml ivermectin. In vivo, brain larval counts significantly decreased in groups I and II (22.67 \u00b1 5.41 and 37.17 \u00b1 5.98), with no significant reduction in group III (130.5 \u00b1 9.01). Histopathology of the liver at four weeks post-infection in groups I and II revealed numerous granulomas with degenerated larvae. The brain showed a marked reduction in larval presence and inflammation in groups I and II, while group III findings were similar to those of the control group.Conclusion. Ivermectin is effective against T. canis larvae during early migratory stages but shows limited efficacy against late-stage larvae.<\/jats:p>","DOI":"10.7705\/biomedica.7828","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:30:47Z","timestamp":1772807447000},"page":"128-140","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stages","Efecto de la ivermectina sobre larvas de Toxocara canis in vitro e in vivo en diferentes etapas migratorias"],"prefix":"10.7705","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-7263","authenticated-orcid":false,"given":"Iman Fathy","family":"Abou-El-Naga","sequence":"first","affiliation":[{"name":"Medical Parasitology Department, Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8074-5145","authenticated-orcid":false,"given":"Suzanne M.F.","family":"El-Nassery","sequence":"additional","affiliation":[{"name":"Medical Parasitology Department, Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-6631","authenticated-orcid":false,"given":"Mona M.","family":"El-Temsahy","sequence":"additional","affiliation":[{"name":"Medical Parasitology Department, Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"159579","doi-asserted-by":"crossref","unstructured":"Chen J, Liu Q, Liu GH, Zheng WB, Hong SJ, Sugiyama H, et al. 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