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Triticum vulgare extract, marketed as Fitostimoline\u2122, is used to stimulate re-epithelialization and tissue regeneration. The use of this extract in chronic ulcers such as diabetic foot ulcers may represent a viable treatment alternative.Objective. To study the effects of 15% T. vulgare extract cream on wound healing in normoglycemic and streptozotocin-induced hyperglycemic BALB\/c mice. Materials and methods. Hyperglycemia was induced in mice with a single dose of streptozotocin (200 mg\/kg) (group STZ-1) or with multiple doses (30 mg\/kg for five consecutive days) (group STZ-2). Excisional wounds were created on the dorsal skin, and T. vulgare extract was applied topically twice daily for ten days. We assessed wound closure, histological changes, and inflammatory markers.Results. Triticum vulgare extract treatment significantly enhanced wound closure in both normoglycemic and hyperglycemic mice compared to controls. Histological analysis revealed fewer mast cells, reduced inflammation in T. vulgare extract-treated groups, and increased collagen deposition in the treated normoglycemic and STZT-1 groups. Triticum vulgare extract treatment also reduced IL-6 and IL-1\u03b2 levels in certain hyperglycemic groups.Conclusions. Overall, in this murine model, the topical application of T. vulgare extract improved wound healing in both normoglycemic and hyperglycemic conditions by accelerating closure, improving histological architecture, and rebalancing inflammatory cytokines toward a pro-healing profile, indicating its potential as a therapeutic option for diabetic wound care. The findings suggest multiple mechanisms of action for T. vulgare extract. Nonetheless, further research is necessary to elucidate these mechanisms and to fully explore potential clinical applications.<\/jats:p>","DOI":"10.7705\/biomedica.7976","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:09:31Z","timestamp":1788268171000},"page":"393-408","update-policy":"https:\/\/doi.org\/10.7705\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the pro-healing effect of a commercial formulation of aqueous extract of Triticum vulgare in hyperglycemic mice","Evaluaci\u00f3n del efecto procicatrizante de una formulaci\u00f3n comercial de extracto acuoso de Triticum vulgare en ratones hipergluc\u00e9micos"],"prefix":"10.7705","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-1163","authenticated-orcid":false,"given":"Omar","family":"Casadiego","sequence":"first","affiliation":[{"name":"Centro de Investigaciones en Enfermedades Tropicales, Departamento de Ciencias B\u00e1sicas, Escuela de Medicina, Universidad Industrial de Santander, Piedecuesta, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3690-3562","authenticated-orcid":false,"given":"Fernando","family":"Rodr\u00edguez-Sanabria","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Enfermedades Tropicales, Departamento de Ciencias B\u00e1sicas, Escuela de Medicina, Universidad Industrial de Santander, Piedecuesta, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8204-6285","authenticated-orcid":false,"given":"Guillermina","family":"Baay-Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Enfermedades Oncol\u00f3gicas, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, M\u00e9xico, D. F., M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-5028","authenticated-orcid":false,"given":"Julio Cesar","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Escuela de Medicina, Universidad Industrial de Santander, Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7527-2364","authenticated-orcid":false,"given":"Patricia","family":"Escobar","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Enfermedades Tropicales, Departamento de Ciencias B\u00e1sicas, Escuela de Medicina, Universidad Industrial de Santander, Piedecuesta, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4444","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"167500","doi-asserted-by":"crossref","unstructured":"Chang M, Nguyen TT. 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Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissue repairing processes in in vitro and in vivo models of skin lesions. J Ethnopharmacol. 2015;159:198-208. https:\/\/doi.org\/10.1016\/j.jep.2014.10.051","DOI":"10.1016\/j.jep.2014.10.051"},{"key":"167532","doi-asserted-by":"crossref","unstructured":"D\u2019Agostino A, Pirozzi AVA, Finamore R, Grieco F, Minale M, Schiraldi C. Molecular mechanisms at the basis of pharmaceutical grade Triticum vulgare extract efficacy in prompting keratinocytes healing. Molecules. 2020;25:431. https:\/\/doi.org\/10.3390\/molecules25030431","DOI":"10.3390\/molecules25030431"},{"key":"167533","doi-asserted-by":"crossref","unstructured":"Bacci S. Fine regulation during wound healing by mast cells, a physiological role not yet clarified. Int J Mol Sci. 2022;23:1820. https:\/\/doi.org\/10.3390\/ijms23031820","DOI":"10.3390\/ijms23031820"},{"key":"167534","doi-asserted-by":"crossref","unstructured":"Shi MA, Shi GP. 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