{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:39:12Z","timestamp":1772267952829,"version":"3.50.1"},"reference-count":28,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n Background<\/jats:title>\n The coronavirus 19 (COVID-19) pandemic has heightened the threat to the health and lives of patients with comorbid diseases. Infection by COVID-19 is especially detrimental to patients on hemodialysis. In this study, we evaluated the clinical characteristics, laboratory findings, treatments and prognoses of hemodialysis patients with COVID-19.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 16 hemodialysis patients with COVID-19 were recruited from Wuhan Fourth Hospital from 5 February to 20 March 2020 for a retrospective, single-center study. A total of 62 non-dialysis patients with COVID-19 were the control group. We collected data on the clinical characteristics, laboratory findings, treatments, and clinical outcomes of patients affected by the virus.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Hemodialysis patients with COVID-19 had a lower incidence of fever (\n P<\/jats:italic>\n = 0.001) and relatively higher incidence of pre-admission comorbidities and shortness of breath than non-dialysis patients with COVID-19 (75% vs. 61%,\n P<\/jats:italic>\n = 0.467 50% vs. 33.87%,\n P<\/jats:italic>\n = 0.248 ). Hemodialysis patients had lower levels of hemoglobin (\n P<\/jats:italic>\n < 0.001), white blood cell counts (\n P<\/jats:italic>\n = 0.015), neutrophils (\n P<\/jats:italic>\n = 0.016), AST (\n P<\/jats:italic>\n = 0.037), ALT (\n P<\/jats:italic>\n < 0.001) and procalcitonin (\n P<\/jats:italic>\n < 0.001), and higher levels of D-dimer (\n P<\/jats:italic>\n < 0.001) and thrombin time (\n P<\/jats:italic>\n < 0.001). Hemodialysis patients had a higher incidence of pulmonary effusion, cord-like high-density shadows, pleural thickening, and atelectasis (\n P<\/jats:italic>\n < 0.05). Hemodialysis patients also had relatively higher rates of mortality and prolonged hospital stays compared with the control group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Hemodialysis patients typically present with multiple comorbidities and are considered to be a high-risk group for COVID-19 infections. Hemodialysis patients with COVID-19 may have prolonged hospital stays and unfavorable prognoses and should be closely monitored.<\/jats:p>\n <\/jats:sec>","DOI":"10.7717\/peerj.10459","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T03:11:47Z","timestamp":1606360307000},"page":"e10459","source":"Crossref","is-referenced-by-count":7,"title":["Characteristics and outcomes of hemodialysis patients with COVID-19: a retrospective single center study"],"prefix":"10.7717","volume":"8","author":[{"given":"Yongwen","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5542-3375","authenticated-orcid":true,"given":"Junli","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Sciences, Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Wuhan Fourth Hospital, Wuhan, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Wuhan Fourth Hospital, Wuhan, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Fourth Hospital, Wuhan, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2019an","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan Fourth Hospital, Wuhan, , 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