{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:20:12Z","timestamp":1792084812624,"version":"4.4.0"},"reference-count":29,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Projects of Science and Technology Development Funds of Nantong","award":["MS32015018"],"award-info":[{"award-number":["MS32015018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>The objective of this study was to examine the clinical characteristics of patients with different cumulative hemodialysis (HD) durations, so as to improve their survival rate.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>In this cross-sectional study, we extracted background information and relevant clinical data from 145 patients who were undergoing maintenance HD three times a week at the Affiliated Hospital of Nantong University between January 1998 and January 2019. The study subjects were divided into four groups according to the duration of their HD: &lt;5 years, 5\u201310 years, 10\u201315 years, and &gt;15 years of HD. We collected the medical history and relevant clinical parameters for each subject, and measured the urea reduction ratio (URR), hemoglobin (Hb), serum calcium, phosphorus, parathyroid hormone (iPTH), and serum albumin (ALB) levels for each group.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>The average patient age was 52.06 \u00b1\u00a0 11.93 years old. The average patient age in the 10\u201315 years and &gt;15 years groups was significantly lower than in the &lt;5 years and 5\u201310 years groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0025, respectively). The most common cause of end-stage renal disease (ESRD) was chronic glomerulonephritis. We found no significant differences in URR, Hb, serum calcium, serum phosphorus, iPTH, and ALB levels.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>A prolonged HD duration was related to a younger mean age at the start of HD treatment. The leading cause of ESRD was chronic glomerulonephritis. We predominantly found diabetic nephropathy in the group with a duration of &lt;5 years cumulative HD. Most of the indexes related to hemodialysis almost satisfied the recommended values in these patients.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.10852","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T11:36:14Z","timestamp":1615289774000},"page":"e10852","source":"Crossref","is-referenced-by-count":1,"title":["Analyzing clinical characteristics of patients with different cumulative hemodialysis durations: a cross-sectional study"],"prefix":"10.7717","volume":"9","author":[{"given":"Xu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"10.7717\/peerj.10852\/ref-1","first-page":"2748","article-title":"Chinese clinical guidelines for adequacy of hemodialysis","volume":"95","author":"Adequate Hemodialysis Work Group of the Chinese Medical Doctor Association","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.7717\/peerj.10852\/ref-2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/ki.2013.243","article-title":"Comments on \u2018KDIGO 2012 Clinical practice guideline for the evaluation and management of chronic kidney disease\u2019","volume":"84","author":"Andrassy","year":"2013","journal-title":"Kidney International Supplements"},{"key":"10.7717\/peerj.10852\/ref-3","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1046\/j.1523-1755.64.s87.3.x","article-title":"Hemoglobin predicts long-term survival in dialysis patients: a 15-year single-center longitudinal study and a correlation trend between prealbumin and hemoglobin","volume":"64","author":"Avram","year":"2003","journal-title":"Kidney International Supplements"},{"key":"10.7717\/peerj.10852\/ref-4","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism mortality and morbidity in maintenance hemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.7717\/peerj.10852\/ref-5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.4103\/0971-4065.132985","article-title":"Survival analysis of patients on maintenance hemodialysis","volume":"24","author":"Chandrashekar","year":"2014","journal-title":"Indian Journal of Nephrology"},{"key":"10.7717\/peerj.10852\/ref-6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.1523-1755.61.s80.9.x","article-title":"Influence of target hemoglobin in dialysis patients on morbidity and mortality","volume":"61","author":"Collins","year":"2002","journal-title":"Kidney International Supplements"},{"key":"10.7717\/peerj.10852\/ref-7","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1111\/j.1523-1755.2005.00593.x","article-title":"Are nutritional status indicators associated with mortality in the Hemodialysis (HEMO) Study?","volume":"68","author":"Dwyer","year":"2005","journal-title":"Kidney International Supplements"},{"key":"10.7717\/peerj.10852\/ref-8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0140-6736(13)60439-0","article-title":"Evolving importance of kidney disease: from subspecialty to global health burden","volume":"382","author":"Eckardt","year":"2013","journal-title":"Lancet"},{"issue":"Suppl 7","key":"10.7717\/peerj.10852\/ref-9","first-page":"7","article-title":"Section I. 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