{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:41:17Z","timestamp":1772268077680,"version":"3.50.1"},"reference-count":38,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"crossref","award":["FHS-CRDA-029-002-2017, EF005\/FHS-ZXH\/2018\/GSTIC, MYRG2018-00071-FHS and SRG2016-00083-FHS"],"award-info":[{"award-number":["FHS-CRDA-029-002-2017, EF005\/FHS-ZXH\/2018\/GSTIC, MYRG2018-00071-FHS and SRG2016-00083-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Macau SAR","award":["0004\/2019\/AFJ"],"award-info":[{"award-number":["0004\/2019\/AFJ"]}]},{"name":"Guangdong Science and Technology Fund","award":["2020B1111300001"],"award-info":[{"award-number":["2020B1111300001"]}]},{"name":"Guangzhou Institute of Respiratory Health Open Project","award":["2020GIRHHMS04"],"award-info":[{"award-number":["2020GIRHHMS04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity lung disease caused by a fungus known as\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    . It complicates and aggravates asthma. Despite their potential associations, the underlying mechanisms of asthma developing into ABPA remain obscure. Here we performed an integrative transcriptome analysis based on three types of human peripheral blood, which derived from ABPA patients, asthmatic patients and health controls, aiming to identify crucial lncRNAs implicated in ABPA and asthma. Initially, a high-confidence dataset of lncRNAs was identified using a stringent filtering pipeline. A comparative mutational analysis revealed no significant difference among these samples. Differential expression analysis disclosed several immune-related mRNAs and lncRNAs differentially expressed in ABPA and asthma. For each disease, three sub-networks were established using differential network analysis. Many key lncRNAs implicated in ABPA and asthma were identified, respectively, i.e., AL139423.1-201, AC106028.4-201, HNRNPUL1-210, PUF60-218 and SREBF1-208. Our analysis indicated that these lncRNAs exhibits in the loss-of-function networks, and the expression of which were repressed in the occurrences of both diseases, implying their important roles in the immune-related processes in response to the occurrence of both diseases. Above all, our analysis proposed a new point of view to explore the relationship between ABPA and asthma, which might provide new clues to unveil the pathogenic mechanisms for both diseases.\n                  <\/jats:p>","DOI":"10.7717\/peerj.11453","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T05:37:57Z","timestamp":1624513077000},"page":"e11453","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive transcriptome analysis of peripheral blood unravels key lncRNAs implicated in ABPA and asthma"],"prefix":"10.7717","volume":"9","author":[{"given":"Chen","family":"Huang","sequence":"first","affiliation":[{"name":"Dr. Neher\u2019s Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Macau, SAR, China, Macau, China"},{"name":"Stat Key laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, SAR, China, Macau, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Leng","sequence":"additional","affiliation":[{"name":"Faculty of Health and Science, University of Macau, Macao, Macau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory, Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Deng","sequence":"additional","affiliation":[{"name":"Faculty of Health and Science, University of Macau, Macao, Macau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory, Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory, Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory, Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua Douglas","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Health and Science, University of Macau, Macao, Macau"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"issue":"5","key":"10.7717\/peerj.11453\/ref-1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s11882-011-0217-4","article-title":"Severe asthma with fungal sensitization","volume":"11","author":"Agarwal","year":"2011","journal-title":"Current Allergy and Asthma Reports"},{"issue":"S1","key":"10.7717\/peerj.11453\/ref-2","doi-asserted-by":"publisher","first-page":"S150","DOI":"10.3109\/13693786.2010.504752","article-title":"Severe asthma and fungi: current 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