{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:43:30Z","timestamp":1788385410999,"version":"build-2803163510"},"reference-count":56,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Key R&D Program of China","award":["2018YFC2001600"],"award-info":[{"award-number":["2018YFC2001600"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81802249"],"award-info":[{"award-number":["81802249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81871836"],"award-info":[{"award-number":["81871836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"crossref","award":["18511108300"],"award-info":[{"award-number":["18511108300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"crossref","award":["18441903903900"],"award-info":[{"award-number":["18441903903900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"crossref","award":["18441903800"],"award-info":[{"award-number":["18441903800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Three-Year Action Plan for Traditional Chinese Medicine Development from Shanghai Municipal Health Commission","award":["ZY(2018-2020)-ZWB-1001-CPJS49"],"award-info":[{"award-number":["ZY(2018-2020)-ZWB-1001-CPJS49"]}]},{"name":"Three-Year Action Plan for Traditional Chinese Medicine Development from Shanghai Municipal Health Commission","award":["ZY(2018-2020)-RCPY-3007"],"award-info":[{"award-number":["ZY(2018-2020)-RCPY-3007"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["Zyjx-2017006"],"award-info":[{"award-number":["Zyjx-2017006"]}]},{"name":"Special project of Postgraduate Innovation Training","award":["A1-GY20-204-0107"],"award-info":[{"award-number":["A1-GY20-204-0107"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Pain, a major symptom of osteonecrosis of the femoral head (ONFH), is a complex sensory and emotional experience that presents therapeutic challenges. Pain can cause neuroplastic changes at the cortical level, leading to central sensitization and difficulties with curative treatments; however, whether changes in structural and functional plasticity occur in patients with ONFH remains unclear.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>A total of 23 ONFH inpatients who did not undergo surgery (14 males, nine females; aged 55.61\u00a0\u00b1\u00a013.79 years) and 20 controls (12 males, eight females; aged 47.25\u00a0\u00b1\u00a019.35 years) were enrolled. Functional indices of the amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and a structural index of tract-based spatial statistics (TBSS) were calculated for each participant. The probability distribution of fiber direction was determined according to the ALFF results.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>ONFH patients demonstrated increased ALFF in the bilateral dorsolateral superior frontal gyrus, right medial superior frontal gyrus, right middle frontal gyrus, and right supplementary motor area. In contrast, ONFH patients showed decreased ReHo in the left superior parietal gyrus and right inferior temporal gyrus. There were no significant differences in TBSS or probabilistic tractography.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>These results indicate cerebral pain processing in ONFH patients. It is advantageous to use functional magnetic resonance imaging to better understand pain pathogenesis and identify new therapeutic targets in ONFH patients.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.11759","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T08:59:31Z","timestamp":1629449971000},"page":"e11759","source":"Crossref","is-referenced-by-count":6,"title":["Alterations in brain structure and function in patients with osteonecrosis of the femoral head: a multimodal MRI study"],"prefix":"10.7717","volume":"9","author":[{"given":"Jie","family":"Ma","sequence":"first","affiliation":[{"name":"School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western 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