{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:35:05Z","timestamp":1792118105578,"version":"4.4.0"},"reference-count":166,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Brazilian Federal Agency for the Support and Evaluation of Graduate Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Minas Gerais Research Foundation"},{"name":"Paraense Amazon Foundation for Support to Studies and Research"},{"name":"National Council for Scientific and Technical Research"},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Corynebacterium pseudotuberculosis<\/jats:italic>\n                      is a Gram-positive facultative intracellular pathogen and the etiologic agent of illnesses like caseous lymphadenitis in small ruminants, mastitis in dairy cattle, ulcerative lymphangitis in equines, and oedematous skin disease in buffalos. With the growing advance in high-throughput technologies, genomic studies have been carried out to explore the molecular basis of its virulence and pathogenicity. However, data large-scale functional genomics studies are necessary to complement genomics data and better understating the molecular basis of a given organism. Here we summarize, MS-based proteomics techniques and bioinformatics tools incorporated in genomic functional studies of\n                      <jats:italic>C. pseudotuberculosis<\/jats:italic>\n                      to discover the different patterns of protein modulation under distinct environmental conditions, and antigenic and drugs targets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      In this study we performed an extensive search in Web of Science of original and relevant articles related to methods, strategy, technology, approaches, and bioinformatics tools focused on the functional study of the genome of\n                      <jats:italic>C. pseudotuberculosis<\/jats:italic>\n                      at the protein level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Here, we highlight the use of proteomics for understating several aspects of the physiology and pathogenesis of\n                      <jats:italic>C. pseudotuberculosis<\/jats:italic>\n                      at the protein level. The implementation and use of protocols, strategies, and proteomics approach to characterize the different subcellular fractions of the proteome of this pathogen. In addition, we have discussed the immunoproteomics, immunoinformatics and genetic tools employed to identify targets for immunoassays, drugs, and vaccines against\n                      <jats:italic>C. pseudotuberculosis<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this review, we showed that the combination of proteomics and bioinformatics studies is a suitable strategy to elucidate the functional aspects of the\n                      <jats:italic>C. pseudotuberculosis<\/jats:italic>\n                      genome. Together, all information generated from these proteomics studies allowed expanding our knowledge about factors related to the pathophysiology of this pathogen.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.12456","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T03:38:15Z","timestamp":1640230695000},"page":"e12456","source":"Crossref","is-referenced-by-count":9,"title":["A journey through the\n                    <i>Corynebacterium pseudotuberculosis<\/i>\n                    proteome promotes insights into its functional genome"],"prefix":"10.7717","volume":"9","author":[{"given":"Wanderson","family":"Marques da Silva","sequence":"first","affiliation":[{"name":"Institute of Agrobiotechnology and Molecular Biology-(INTA\/CONICET), Hurlingham, Buenos Aires, 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