{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:33:56Z","timestamp":1776882836907,"version":"3.51.2"},"reference-count":71,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACYT\u2013Mexico","award":["A1-S-10669"],"award-info":[{"award-number":["A1-S-10669"]}]},{"name":"PAPIIT-UNAM","award":["IN220019"],"award-info":[{"award-number":["IN220019"]}]},{"name":"CONACYT\u2013Mexico Ph.D","award":["369794"],"award-info":[{"award-number":["369794"]}]},{"name":"Fondo semilla-2019","award":["CIP-PI-029-2018-2"],"award-info":[{"award-number":["CIP-PI-029-2018-2"]}]},{"name":"FCS-Universidad Panamericana given to Victor Galvez (CVU","award":["421958)"],"award-info":[{"award-number":["421958)"]}]},{"name":"Programa de Doctorado en Ciencias Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de Mexico","award":["574022\/403010 (CVU: 660496)"],"award-info":[{"award-number":["574022\/403010 (CVU: 660496)"]}]},{"name":"Fondo Sectorial de Investigaci\u00f3n para la Educaci\u00f3n B\u00e1sica from CONACYT\u2013Mexico","award":["CB-2017-2018-A1-S-10669-M-5248"],"award-info":[{"award-number":["CB-2017-2018-A1-S-10669-M-5248"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Huntington\u2019s Disease (HD) is an autosomal neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. Cognitive impairment develops gradually in HD patients, progressing later into a severe cognitive dysfunction. The Montreal Cognitive Assessment (MoCA) is a brief screening test commonly employed to detect mild cognitive impairment, which has also been useful to assess cognitive decline in HD patients. However, the relationship between MoCA performance and brain structural integrity in HD patients remains unclear. Therefore, to explore this relationship we analyzed if cortical thinning and subcortical nuclei volume differences correlated with HD patients\u2019 MoCA performance. Twenty-two HD patients and twenty-two healthy subjects participated in this study. T1-weighted images were acquired to analyze cortical thickness and subcortical nuclei volumes. Group comparison analysis showed a significantly lower score in the MoCA global performance of HD patients. Also, the MoCA total score correlated with cortical thinning of fronto-parietal and temporo-occipital cortices, as well as with bilateral caudate volume differences in HD patients. These results provide new insights into the effectiveness of using the MoCA test to detect cognitive impairment and the brain atrophy pattern associated with the cognitive status of prodromal\/early HD patients.<\/jats:p>","DOI":"10.7717\/peerj.12917","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T04:28:14Z","timestamp":1649046494000},"page":"e12917","source":"Crossref","is-referenced-by-count":4,"title":["Montreal Cognitive Assessment (MoCA) performance in Huntington\u2019s disease patients correlates with cortical and caudate atrophy"],"prefix":"10.7717","volume":"10","author":[{"given":"Gabriel","family":"Ramirez-Garcia","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Universidad Nacional Aut\u00f3noma de Mexico, Ciudad de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Galvez","sequence":"additional","affiliation":[{"name":"Escuela de Psicolog\u00eda, Universidad Panamericana, Ciudad de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinda","family":"Diaz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Universidad Nacional Aut\u00f3noma de Mexico, Ciudad de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3608-8660","authenticated-orcid":true,"given":"Aurelio","family":"Campos-Romo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Unidad Perif\u00e9rica de Neurociencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico\/Instituto Nacional de Neurologia y Neurocirugia, Ciudad de Mexico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Fernandez-Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Universidad Nacional Aut\u00f3noma de Mexico, Ciudad de Mexico, 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