{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:47:12Z","timestamp":1775911632734,"version":"3.50.1"},"reference-count":85,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"The Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil (CAPES) - Finance Code 001 and JSPS KAKENHI","award":["21K12269"],"award-info":[{"award-number":["21K12269"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hosts and their microbiota and parasites have co-evolved in an adaptative relationship since ancient times. The interaction between parasites and intestinal bacteria in terms of the hosts\u2019 health is currently a subject of great research interest. Therapeutic interventions can include manipulations of the structure of the intestinal microbiota, which have immunological interactions important for modulating the host\u2019s immune system and for reducing inflammation. Most helminths are intestinal parasites; the intestinal environment provides complex interactions with other microorganisms in which internal and external factors can influence the composition of the intestinal microbiota. Moreover, helminths and intestinal microorganisms can modulate the host\u2019s immune system either beneficially or harmfully. The immune response can be reduced due to co-infection, and bacteria from the intestinal microbiota can translocate to other organs. In this way, the treatment can be compromised, which, together with drug resistance by the parasites makes healing even more difficult. Thus, this work aimed to understand interactions between the microbiota and parasitic diseases caused by the most important geohelminths and schistosomiasis and the consequences of these associations.<\/jats:p>","DOI":"10.7717\/peerj.13401","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T03:19:07Z","timestamp":1651720747000},"page":"e13401","source":"Crossref","is-referenced-by-count":7,"title":["Unbalanced relationships: insights into the interaction between gut microbiota, geohelminths, and schistosomiasis"],"prefix":"10.7717","volume":"10","author":[{"given":"Matheus","family":"Pereira de Ara\u00fajo","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Universidade Federal de Alfenas, Alfenas, Minas Gerais, Brazil"},{"name":"Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello Otake","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Sato","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Niigata University, Niigata, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasun M.","family":"Bandara WM","sequence":"additional","affiliation":[{"name":"The Open University Sri Lanka, Nawala, Nugegoda, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Felipe Leomil","family":"Coelho","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Universidade Federal de Alfenas, Alfenas, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Lopes Martins","family":"Souza","sequence":"additional","affiliation":[{"name":"Institute 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