{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:54:40Z","timestamp":1785826480611,"version":"3.56.0"},"reference-count":39,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Second Hospital of Lanzhou University Cuiying Science","award":["CY2019-BJ14"],"award-info":[{"award-number":["CY2019-BJ14"]}]},{"name":"The Foundation of Education Department of Gansu Province","award":["2020b-045"],"award-info":[{"award-number":["2020b-045"]}]},{"name":"The Second Hospital of Lanzhou University Cuiying Science","award":["CY2019-QN20"],"award-info":[{"award-number":["CY2019-QN20"]}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"crossref","award":["18JR3RA328"],"award-info":[{"award-number":["18JR3RA328"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n Objective<\/jats:title>\n In this study, serum markers of acute ischemic stroke (AICS) with carotid artery plaque were retrospectively evaluated to establish a basis for discovering serological indicators for early warning of acute ischemic stroke (AICS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 248 patients with AICS were enrolled in Lanzhou University Second Hospital from January 2019 to December 2020. The study population included 136 males and 112 females, 64\u00a0\u00b1\u00a011 years of age. Of these, there were 90 patients with a transient ischemic attack (TIA), including 60 males and 30 females, aged 64\u00a0\u00b1\u00a08 years old. Patients with AICS were stratified by carotid ultrasound into a plaque group (\n n<\/jats:italic>\n \u00a0=\u00a0154) and a non-plaque group (\n n<\/jats:italic>\n \u00a0=\u00a094). A total of 160 healthy subjects were selected as the control group. Serum lipoprotein-associated phospholipase A2 (Lp-PLA2), amyloid A (SAA), immunoglobulin E (IgE), D-dimer (D-D), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) were collected from all subjects. Multivariate logistic regression was used to analyze the risk factors of AICS with carotid plaque. ROC curve was used to analyze the diagnostic efficacy of AICS with carotid plaque.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The IgE, Lp-PLA2, SAA, LDL-C, TC, TG, and D-D levels in the AICS group were higher than those in the TIA group and healthy control group (\n P<\/jats:italic>\n \u00a0<\u00a00.05). The IgE level was significantly higher than that in the healthy control group and TIA group. The IgE level in the AICS plaque group was significantly higher than that in the AICS non-plaque group (\n P<\/jats:italic>\n \u00a0<\u00a00.01), and the Lp-PLA2 level was also different (\n P<\/jats:italic>\n \u00a0<\u00a00.05). The incidence of AICS was positively correlated with Lp-PLA2, TC, IgE, TG, D-D, SAA and LDL-C (\n r<\/jats:italic>\n \u00a0=\u00a00.611, 0.499, 0.478, 0.431, 0.386, 0.332, 0.280, all\n P<\/jats:italic>\n \u00a0<\u00a00.05). The incidence of AICS with plaque was only positively correlated with IgE and Lp-PLA2 (\n r<\/jats:italic>\n \u00a0=\u00a00.588, 0.246,\n P<\/jats:italic>\n \u00a0<\u00a00.05). Logistic regression analysis showed that IgE and Lp-PLA2 were independent risk factors for predicting the occurrence of AICS with carotid plaque (\n P<\/jats:italic>\n \u00a0<\u00a00.05). ROC curve analysis showed that the AUC of IgE (0.849) was significantly higher than other indicators; its sensitivity and specificity were also the highest, indicating that IgE can improve the diagnostic efficiency of AICS with carotid plaque.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n IgE is a serum laboratory indicator used to diagnose AICS disease with carotid plaque, which lays a foundation for further research on potential early warning indicators of AICS disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.7717\/peerj.14235","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T03:38:46Z","timestamp":1666755526000},"page":"e14235","source":"Crossref","is-referenced-by-count":8,"title":["A retrospective study of immunoglobulin E as a biomarker for the diagnosis of acute ischemic stroke with carotid atherosclerotic plaques"],"prefix":"10.7717","volume":"10","author":[{"given":"Wenwen","family":"Jiang","sequence":"first","affiliation":[{"name":"Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindou","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Maternal and Child Health Hospital of Gansu Province, Lanzhou, Gansu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqiang","family":"Dang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijiao","family":"Qi","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"issue":"2","key":"10.7717\/peerj.14235\/ref-1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/imm.13295","article-title":"The turning away of serum amyloid A biological activities and receptor usage","volume":"163","author":"Abouelasrar Salama","year":"2021","journal-title":"Immunology"},{"issue":"21","key":"10.7717\/peerj.14235\/ref-2","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMsb020987","article-title":"Transient ischemic attack\u2014proposal for a new definition","volume":"47","author":"Albers","year":"2002","journal-title":"New England Journal of Medicine"},{"issue":"6","key":"10.7717\/peerj.14235\/ref-3","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJMoa061894","article-title":"High-dose atorvastatin afterstroke or transient ischemic attack","volume":"355","author":"Amarenco","year":"2006","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10.7717\/peerj.14235\/ref-4","doi-asserted-by":"publisher","first-page":"165260","DOI":"10.1016\/j.bbadis.2018.09.012","article-title":"Current advances in ischemic stroke research and therapies","volume":"1866","author":"Barthels","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA) - 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