{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:33:15Z","timestamp":1787236395605,"version":"build-2736575974"},"reference-count":48,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Medical and Health Science Technology Development Project","award":["202009011360"],"award-info":[{"award-number":["202009011360"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Cognitive impairment (CI) is very common in patients with chronic obstructive pulmonary disease (COPD). Cerebral structural and functional abnormalities have been reported in cognitively impaired patients with COPD, and the neurovascular coupling changes are rarely investigated. To address this issue, arterial spin labeling (ASL) and resting-state blood oxygenation level dependent (BOLD) fMRI techniques were used to determine whether any neurovascular changes in COPD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-five stable COPD patients and forty gender- and age-matched healthy controls were recruited. Furthermore, resting-state BOLD fMRI and ASL were acquired to calculate degree centrality (DC) and cerebral blood flow (CBF) respectively. The CBF-DC coupling and CBF\/DC ratio were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>COPD patients showed abnormal CBF, DC and CBF\/DC ratio in several regions. Moreover, lower CBF\/DC ratio in the left lingual gyrus negatively correlated with naming scores, lower CBF\/DC ratio in medial frontal cortex\/temporal gyrus positively correlated with the Montreal Cognitive Assessment (MoCA), visuospatial\/executive and delayed recall scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings may provide new potential insights into neuropathogenesis of cognition decline in stable COPD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.14249","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T03:17:55Z","timestamp":1668395875000},"page":"e14249","source":"Crossref","is-referenced-by-count":8,"title":["Cerebral neurovascular alterations in stable chronic obstructive pulmonary disease: a preliminary fMRI 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