{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:50Z","timestamp":1791919730446,"version":"4.3.4"},"reference-count":150,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Fund for Talents of China Three Gorges University","award":["1910103"],"award-info":[{"award-number":["1910103"]}]},{"name":"Science and Technology Bureau of Guangzhou City School (college) co-funded Project","award":["202201020296"],"award-info":[{"award-number":["202201020296"]}]},{"DOI":"10.13039\/100012829","name":"Guangdong Provincial Hospital of Chinese Medicine Science and Technology Research Program","doi-asserted-by":"crossref","award":["YN2019MJ11"],"award-info":[{"award-number":["YN2019MJ11"]}],"id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people\u2019s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and\/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment.<\/jats:p>","DOI":"10.7717\/peerj.14952","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:35:00Z","timestamp":1678685700000},"page":"e14952","source":"Crossref","is-referenced-by-count":40,"title":["Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review"],"prefix":"10.7717","volume":"11","author":[{"given":"Cuihua","family":"Liu","sequence":"first","affiliation":[{"name":"Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunjiang","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botao","family":"Li","sequence":"additional","affiliation":[{"name":"Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuncheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"issue":"4","key":"10.7717\/peerj.14952\/ref-1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nrcardio.2017.154","article-title":"Epidemiology of cardiovascular disease in young individuals","volume":"15","author":"Andersson","year":"2018","journal-title":"Nature Reviews Cardiology"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-2","doi-asserted-by":"publisher","first-page":"H659","DOI":"10.1152\/ajpheart.00452.2017","article-title":"Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes","volume":"314","author":"Baba","year":"2018","journal-title":"American Journal of Physiology-Heart and Circulatory"},{"key":"10.7717\/peerj.14952\/ref-3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2020.07.026","article-title":"Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell","volume":"160","author":"Bai","year":"2020","journal-title":"Free Radical Biology and Medicine"},{"issue":"6","key":"10.7717\/peerj.14952\/ref-4","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.3390\/cells9061505","article-title":"Ferroptosis and cancer: mitochondria meet the iron maiden cell death","volume":"9","author":"Battaglia","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cmet.2012.10.001","article-title":"mTOR regulates cellular iron homeostasis through tristetraprolin","volume":"16","author":"Bayeva","year":"2012","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-6","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.bbagen.2011.07.014","article-title":"Non-transferrin bound iron: a key role in iron overload and iron toxicity","volume":"1820","author":"Brissot","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"S1","key":"10.7717\/peerj.14952\/ref-7","first-page":"137","article-title":"Study on mechanism of Luhong Formula reducing myocardial ischemia-reperfusion injury through SLC7A11\/ GPx4 signal pathway","volume":"36","author":"Cai","year":"2022","journal-title":"Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai"},{"issue":"11\u201312","key":"10.7717\/peerj.14952\/ref-8","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"10","key":"10.7717\/peerj.14952\/ref-9","doi-asserted-by":"publisher","first-page":"6897","DOI":"10.1111\/jcmm.14573","article-title":"Poly (ADP-ribose) polymerase inhibition protects against myocardial ischaemia\/reperfusion injury via suppressing mitophagy","volume":"23","author":"Cao","year":"2019","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1080\/10715762.2021.1876856","article-title":"Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation","volume":"55","author":"Chen","year":"2021","journal-title":"Free Radical Research"},{"issue":"9","key":"10.7717\/peerj.14952\/ref-11","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1002\/jcb.25147","article-title":"Iron regulatory protein 1 suppresses hypoxia-induced iron uptake proteins expression and decreases iron levels in HepG2 cells","volume":"116","author":"Cheng","year":"2015","journal-title":"Journal of Cellular Biochemistry"},{"issue":"6","key":"10.7717\/peerj.14952\/ref-12","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D\u2019Arcy","year":"2019","journal-title":"Cell Biology International"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-13","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-14","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/s1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/02713683.2021.2021586","article-title":"FUNDC1 induces apoptosis and autophagy under oxidative stress via PI3K\/Akt\/mTOR pathway in cataract Lens cells","volume":"47","author":"Dong","year":"2022","journal-title":"Current Eye Research"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-16","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12265-010-9174-x","article-title":"Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors","volume":"3","author":"Dorn","year":"2010","journal-title":"Journal of Cardiovascular Translational Research"},{"key":"10.7717\/peerj.14952\/ref-17","doi-asserted-by":"publisher","first-page":"628988","DOI":"10.3389\/fphar.2021.628988","article-title":"Baicalin prevents myocardial ischemia\/reperfusion injury through inhibiting ACSL4 mediated ferroptosis","volume":"12","author":"Fan","year":"2021","journal-title":"Frontiers in Pharmacology"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-18","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/CIRCRESAHA.120.316509","article-title":"Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis","volume":"127","author":"Fang","year":"2020","journal-title":"Circulation Research"},{"issue":"7","key":"10.7717\/peerj.14952\/ref-19","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-20","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.bbrc.2019.10.006","article-title":"Liproxstatin-1 protects the mouse myocardium against ischemia\/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels","volume":"520","author":"Feng","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"9","key":"10.7717\/peerj.14952\/ref-21","doi-asserted-by":"publisher","first-page":"e202105043","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"Journal of Cell Biology"},{"key":"10.7717\/peerj.14952\/ref-22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/978-981-13-9589-5_2","article-title":"Cellular iron metabolism and regulation","volume":"1173","author":"Gao","year":"2019","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Molecular Cell"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-24","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Molecular Cell"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.hlc.2020.05.108","article-title":"Cardiovascular disease in women: from pathophysiology to novel and emerging risk factors","volume":"30","author":"Geraghty","year":"2021","journal-title":"Heart, Lung and Circulation"},{"key":"10.7717\/peerj.14952\/ref-26","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-59295-0_45","article-title":"Iron overload","volume-title":"Essentials of Blood Product Management in Anesthesia Practice","author":"Godbold","year":"2021"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-27","doi-asserted-by":"publisher","first-page":"G397","DOI":"10.1152\/ajpgi.00348.2013","article-title":"Mechanistic and regulatory aspects of intestinal iron absorption","volume":"307","author":"Gulec","year":"2014","journal-title":"The American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-28","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"Journal of Clinical Investigation"},{"issue":"8","key":"10.7717\/peerj.14952\/ref-29","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3390\/cells8080897","article-title":"Parkin-dependent mitophagy is required for the inhibition of ATF4 on NLRP3 inflammasome activation in cerebral ischemia-reperfusion injury in rats","volume":"8","author":"He","year":"2019","journal-title":"Cells"},{"issue":"8","key":"10.7717\/peerj.14952\/ref-30","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"10.7717\/peerj.14952\/ref-31","doi-asserted-by":"publisher","first-page":"104371","DOI":"10.1016\/j.mvr.2022.104371","article-title":"PCSK9 inhibition protects against myocardial ischemia-reperfusion injury via suppressing autophagy","volume":"142","author":"Huang","year":"2022","journal-title":"Microvascular Research"},{"issue":"10","key":"10.7717\/peerj.14952\/ref-32","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.3390\/antiox10101624","article-title":"Histochrome attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis-induced cardiomyocyte death","volume":"10","author":"Hwang","year":"2021","journal-title":"Antioxidants"},{"key":"10.7717\/peerj.14952\/ref-33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/82_2016_508","article-title":"Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis","volume":"403","author":"Imai","year":"2017","journal-title":"Current Topics in Microbiology and Immunology"},{"key":"10.7717\/peerj.14952\/ref-34","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2018.01.019","article-title":"Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis","volume":"117","author":"Jelinek","year":"2018","journal-title":"Free Radical Biology and Medicine"},{"key":"10.7717\/peerj.14952\/ref-35","doi-asserted-by":"publisher","first-page":"700585","DOI":"10.3389\/fphys.2021.700585","article-title":"Molecular perspectives of mitophagy in myocardial stress: pathophysiology and therapeutic targets","volume":"12","author":"Ji","year":"2021","journal-title":"Frontiers in Physiology"},{"issue":"7545","key":"10.7717\/peerj.14952\/ref-36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-37","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.7150\/thno.43895","article-title":"Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia\/reperfusion injury through inhibiting ROS production from mitochondrial complex I","volume":"11","author":"Jiang","year":"2021","journal-title":"Theranostics"},{"issue":"13","key":"10.7717\/peerj.14952\/ref-38","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-39","doi-asserted-by":"publisher","first-page":"e202004029","DOI":"10.1083\/jcb.202004029","article-title":"Mitophagy pathways in health and disease","volume":"219","author":"Killackey","year":"2020","journal-title":"Journal of Cell Biology"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-40","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nature Cell Biology"},{"issue":"10","key":"10.7717\/peerj.14952\/ref-41","doi-asserted-by":"publisher","first-page":"529","DOI":"10.5483\/bmbrep.2016.49.10.115","article-title":"Mitophagy: a balance regulator of NLRP3 inflammasome activation","volume":"49","author":"Kim","year":"2016","journal-title":"BMB Reports"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-42","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.bbamcr.2010.09.013","article-title":"Is mPTP the gatekeeper for necrosis, apoptosis, or both?","volume":"1813","author":"Kinnally","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"10.7717\/peerj.14952\/ref-43","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.2174\/1389450119666180605112235","article-title":"Pathological roles of iron in cardiovascular disease","volume":"19","author":"Kobayashi","year":"2018","journal-title":"Current Drug Targets"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-44","doi-asserted-by":"publisher","first-page":"H2025","DOI":"10.1152\/ajpheart.00552.2008","article-title":"Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion","volume":"295","author":"Kubli","year":"2008","journal-title":"American Journal of Physiology-Heart and Circulatory"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-45","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1161\/CIRCULATIONAHA.118.036259","article-title":"Mitochondrial dysfunction in heart failure with preserved ejection fraction","volume":"139","author":"Kumar","year":"2019","journal-title":"Circulation"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-46","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41467-017-00520-9","article-title":"Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy","volume":"8","author":"Laker","year":"2017","journal-title":"Nature Communications"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1089\/rej.2005.8.3","article-title":"Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging","volume":"8","author":"Lemasters","year":"2005","journal-title":"Rejuvenation Research"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-48","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.yjmcc.2011.06.026","article-title":"Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection","volume":"51","author":"Leucker","year":"2011","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-49","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death & Disease"},{"issue":"6","key":"10.7717\/peerj.14952\/ref-50","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1172\/JCI126428","article-title":"Ferroptotic cell death and TLR4\/Trif signaling initiate neutrophil recruitment after heart transplantation","volume":"129","author":"Li","year":"2019","journal-title":"Journal of Clinical Investigation"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-51","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00018-022-04239-9","article-title":"Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets","volume":"79","author":"Li","year":"2022","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.7717\/peerj.14952\/ref-52","doi-asserted-by":"publisher","first-page":"105466","DOI":"10.1016\/j.phrs.2021.105466","article-title":"Ferroptosis and its emerging roles in cardiovascular diseases","volume":"166","author":"Li","year":"2021","journal-title":"Pharmacological Research"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-53","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1089\/dna.2019.5097","article-title":"Ferroptosis is involved in diabetes myocardial ischemia\/reperfusion injury through endoplasmic reticulum stress","volume":"39","author":"Li","year":"2020","journal-title":"DNA and Cell Biology"},{"key":"10.7717\/peerj.14952\/ref-54","doi-asserted-by":"publisher","first-page":"788634","DOI":"10.3389\/fcell.2021.788634","article-title":"FUNDC1: a promising mitophagy regulator at the mitochondria-associated membrane for cardiovascular diseases","volume":"9","author":"Li","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.7717\/peerj.14952\/ref-55","doi-asserted-by":"publisher","first-page":"145968","DOI":"10.1016\/j.gene.2021.145968","article-title":"Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis","volume":"808","author":"Li","year":"2022","journal-title":"Gene"},{"key":"10.7717\/peerj.14952\/ref-56","doi-asserted-by":"publisher","first-page":"6617256","DOI":"10.1155\/2021\/6617256","article-title":"The role of mitophagy in regulating cell death","volume":"2021","author":"Li","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.7717\/peerj.14952\/ref-57","doi-asserted-by":"publisher","first-page":"9523491","DOI":"10.1155\/2022\/9523491","article-title":"Xanthohumol protects the rat myocardium against ischemia\/reperfusion injury-induced ferroptosis","volume":"2022","author":"Lin","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-58","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.3390\/biom11111667","article-title":"Gossypol acetic acid attenuates cardiac ischemia\/reperfusion injury in rats via an antiferroptotic mechanism","volume":"11","author":"Lin","year":"2021","journal-title":"Biomolecules"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-59","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"Liu","year":"2012","journal-title":"Nature Cell Biology"},{"key":"10.7717\/peerj.14952\/ref-60","doi-asserted-by":"publisher","first-page":"807654","DOI":"10.3389\/fphys.2021.807654","article-title":"The emerging role of FUNDC1-mediated mitophagy in cardiovascular diseases","volume":"12","author":"Liu","year":"2021","journal-title":"Frontiers in Physiology"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-61","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1001\/jamacardio.2019.0295","article-title":"Burden of cardiovascular diseases in China, 1990\u20132016: findings from the 2016 global burden of disease study","volume":"4","author":"Liu","year":"2019","journal-title":"JAMA Cardiology"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-62","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/FJC.0000000000000640","article-title":"Panax notoginseng saponins attenuate myocardial Iischemia-reperfusion injury through the HIF-1alpha\/BNIP3 pathway of autophagy","volume":"73","author":"Liu","year":"2019","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-63","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1002\/2211-5463.13276","article-title":"Icariin inhibits hypoxia\/reoxygenation-induced ferroptosis of cardiomyocytes via regulation of the Nrf2\/HO-1 signaling pathway","volume":"11","author":"Liu","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-64","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/FJC.0000000000001199","article-title":"Ferulic acid alleviates myocardial ischemia reperfusion injury via upregulating AMPKalpha2 expression-mediated ferroptosis depression","volume":"79","author":"Liu","year":"2021","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"1\u20132","key":"10.7717\/peerj.14952\/ref-65","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41417-020-0182-y","article-title":"Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death","volume":"28","author":"Liu","year":"2021","journal-title":"Cancer Gene Therapy"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-66","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s10637-021-01070-0","article-title":"System Xc(-): a key regulatory target of ferroptosis in cancer","volume":"39","author":"Liu","year":"2021","journal-title":"Investigational New Drugs"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-67","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochimica et Biophysica Acta"},{"issue":"03","key":"10.7717\/peerj.14952\/ref-68","doi-asserted-by":"publisher","first-page":"418","DOI":"10.19405\/j.cnki.issn1000-1492.2019.03.016","article-title":"Schisandrin B alleviates myocardial ischemia\/reperfusion injuryvia maintaining mitophagy","volume":"54","author":"Lu","year":"2019","journal-title":"Acta Universitatis Medicinalis Anhui"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-69","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1080\/13880209.2021.2007269","article-title":"Britanin relieves ferroptosis-mediated myocardial ischaemia\/reperfusion damage by upregulating GPX4 through activation of AMPK\/GSK3beta\/Nrf2 signalling","volume":"60","author":"Lu","year":"2022","journal-title":"Pharmaceutical Biology"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-70","doi-asserted-by":"publisher","first-page":"297","DOI":"10.4161\/auto.18658","article-title":"Enhancing iysosome biogenesis attenuates BNIP3-induced cardiomyocyte death","volume":"8","author":"Ma","year":"2012","journal-title":"Autophagy"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-71","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3969\/j.issn.2095-1736.2021.04.109","article-title":"The molecular mechanisms of ferroptosis","volume":"38","author":"Ma","year":"2021","journal-title":"Journal of Biology"},{"issue":"8","key":"10.7717\/peerj.14952\/ref-72","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nature Reviews Drug Discovery"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-73","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/nyas.13008","article-title":"Iron and cancer: recent insights","volume":"1368","author":"Manz","year":"2016","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-74","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1080\/15548627.2020.1755120","article-title":"Dimerization of mitophagy receptor BNIP3L\/NIX is essential for recruitment of autophagic machinery","volume":"17","author":"Marinkovic","year":"2021","journal-title":"Autophagy"},{"key":"10.7717\/peerj.14952\/ref-75","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fnmol.2017.00064","article-title":"Neuronal mitophagy in neurodegenerative diseases","volume":"10","author":"Martinez Vicente","year":"2017","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-76","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s11655-022-3620-x","article-title":"Shenmai injection attenuates myocardial ischemia\/reperfusion injury by targeting Nrf2\/GPX4 signalling-mediated ferroptosis","volume":"28","author":"Mei","year":"2022","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"10.7717\/peerj.14952\/ref-77","doi-asserted-by":"publisher","first-page":"101328","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biology"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-78","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.cardfail.2010.05.009","article-title":"Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment","volume":"16","author":"Murphy","year":"2010","journal-title":"Journal of Cardiac Failure"},{"issue":"9","key":"10.7717\/peerj.14952\/ref-79","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.bbagen.2019.06.010","article-title":"Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases","volume":"1863","author":"Nakamura","year":"2019","journal-title":"Biochimica et Biophysica Acta: General Subjects"},{"issue":"8","key":"10.7717\/peerj.14952\/ref-80","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/s41419-021-04054-3","article-title":"Ferroptosis: the potential value target in atherosclerosis","volume":"12","author":"Ouyang","year":"2021","journal-title":"Cell Death & Disease"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-81","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death & Disease"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-82","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41419-019-2061-8","article-title":"Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death & Disease"},{"issue":"8","key":"10.7717\/peerj.14952\/ref-83","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1080\/1061186X.2022.2085728","article-title":"Targeted mitochondrial drugs for treatment of Myocardial ischemia-reperfusion injury","volume":"30","author":"Peng","year":"2022","journal-title":"Journal of Drug Targeting"},{"key":"10.7717\/peerj.14952\/ref-84","doi-asserted-by":"publisher","first-page":"25","DOI":"10.21037\/tgh.2019.11.15","article-title":"Inherited iron overload disorders","volume":"5","author":"Piperno","year":"2020","journal-title":"Translational Gastroenterology and Hepatology"},{"issue":"2017","key":"10.7717\/peerj.14952\/ref-85","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.freeradbiomed.2017.02.032","article-title":"The role of mitochondria in cardiac development and protection","volume":"106","author":"Pohjoismaki","year":"2017","journal-title":"Free Radical Biology and Medicine"},{"issue":"12","key":"10.7717\/peerj.14952\/ref-86","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1158\/1541-7786.MCR-16-0028","article-title":"Increased expression of system xc- in glioblastoma confers an altered metabolic state and temozolomide resistance","volume":"14","author":"Polewski","year":"2016","journal-title":"Molecular Cancer Research"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-87","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/ALN.0b013e3181a91957","article-title":"Anesthetic-induced preconditioning delays opening of mitochondrial permeability transition pore via protein Kinase C-epsilon-mediated pathway","volume":"111","author":"Pravdic","year":"2009","journal-title":"Anesthesiology"},{"issue":"10","key":"10.7717\/peerj.14952\/ref-88","first-page":"3198","article-title":"Xin Fu Kang oral liquid inhibits excessive myocardial mitophagy in a rat model of advanced heart failure","volume":"10","author":"Qiu","year":"2018","journal-title":"American Journal of Translational Research"},{"key":"10.7717\/peerj.14952\/ref-89","doi-asserted-by":"publisher","first-page":"5220368","DOI":"10.1155\/2022\/5220368","article-title":"Ferroptosis-related long noncoding RNAs as prognostic marker for colon adenocarcinoma","volume":"2022","author":"Qiu","year":"2022","journal-title":"Applied Bionics and Biomechanics"},{"issue":"6","key":"10.7717\/peerj.14952\/ref-90","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1080\/1061186X.2020.1867992","article-title":"Mitochondria autophagy: a potential target for cancer therapy","volume":"29","author":"Qiu","year":"2021","journal-title":"Journal of Drug Targeting"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-91","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41598-018-19213-4","article-title":"The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin\u2019s cytotoxicity in cancer cells","volume":"8","author":"Sato","year":"2018","journal-title":"Scientific Reports"},{"issue":"21","key":"10.7717\/peerj.14952\/ref-92","doi-asserted-by":"publisher","first-page":"7410","DOI":"10.1073\/pnas.0801318105","article-title":"Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle","volume":"105","author":"Sendamarai","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.7717\/peerj.14952\/ref-93","doi-asserted-by":"publisher","first-page":"8880141","DOI":"10.1155\/2021\/8880141","article-title":"The protective effect of cyanidin-3-glucoside on myocardial ischemia-reperfusion injury through ferroptosis","volume":"2021","author":"Shan","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"12","key":"10.7717\/peerj.14952\/ref-94","doi-asserted-by":"publisher","first-page":"e143691","DOI":"10.1172\/JCI143691","article-title":"HIF-2alpha activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron","volume":"131","author":"Singhal","year":"2021","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-95","doi-asserted-by":"publisher","first-page":"H1170","DOI":"10.1152\/ajpheart.00237.2020","article-title":"Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury","volume":"320","author":"Stamenkovic","year":"2021","journal-title":"American Journal of Physiology-Heart and Circulatory"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-96","doi-asserted-by":"publisher","first-page":"H156","DOI":"10.1152\/ajpheart.00076.2019","article-title":"Phospholipid oxidation products in ferroptotic myocardial cell death","volume":"317","author":"Stamenkovic","year":"2019","journal-title":"American Journal of Physiology-Heart and Circulatory"},{"key":"10.7717\/peerj.14952\/ref-97","doi-asserted-by":"publisher","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.7717\/peerj.14952\/ref-98","doi-asserted-by":"publisher","first-page":"108241","DOI":"10.1016\/j.abb.2019.108241","article-title":"The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes","volume":"680","author":"Sumneang","year":"2020","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"34","key":"10.7717\/peerj.14952\/ref-99","doi-asserted-by":"publisher","first-page":"24142","DOI":"10.1074\/jbc.274.34.24142","article-title":"Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation","volume":"274","author":"Tacchini","year":"1999","journal-title":"Journal of Biological Chemistry"},{"issue":"9","key":"10.7717\/peerj.14952\/ref-100","doi-asserted-by":"publisher","first-page":"e132747","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-101","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.freeradbiomed.2008.05.003","article-title":"Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart","volume":"45","author":"Tang","year":"2008","journal-title":"Free Radical Biology and Medicine"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-102","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11255-019-02335-7","article-title":"Ferroptosis and kidney diseases","volume":"52","author":"Tang","year":"2020","journal-title":"International Urology and Nephrology"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-103","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc3495","article-title":"Iron and cancer: more ore to be mined","volume":"13","author":"Torti","year":"2013","journal-title":"Nature Reviews Cancer"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-104","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41569-021-00607-3","article-title":"Epidemiology of cardiovascular disease in Europe","volume":"19","author":"Townsend","year":"2022","journal-title":"Nature Reviews Cardiology"},{"key":"10.7717\/peerj.14952\/ref-105","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radical Biology and Medicine"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","article-title":"Redox- and non-redox-metal-induced formation of free radicals and their role in human disease","volume":"90","author":"Valko","year":"2016","journal-title":"Archives of Toxicology"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-107","first-page":"51","article-title":"The regulation of iron absorption and homeostasis","volume":"37","author":"Wallace","year":"2016","journal-title":"Clinical Biochemist Reviews"},{"issue":"09","key":"10.7717\/peerj.14952\/ref-108","doi-asserted-by":"publisher","first-page":"886","DOI":"10.13376\/j.cbls\/2019109","article-title":"Research progress of ferroptosis in cardiovascular and cerebrovascular diseases","volume":"31","author":"Wang","year":"2019","journal-title":"Chinese Bulletin of Life Sciences"},{"key":"10.7717\/peerj.14952\/ref-109","doi-asserted-by":"publisher","first-page":"152770","DOI":"10.1016\/j.tox.2021.152770","article-title":"Exposure to PM2.5 aggravates Parkinson\u2019s disease via inhibition of autophagy and mitophagy pathway","volume":"456","author":"Wang","year":"2021","journal-title":"Toxicology"},{"issue":"7","key":"10.7717\/peerj.14952\/ref-110","doi-asserted-by":"publisher","first-page":"980","DOI":"10.12122\/j.issn.1673-4254.2021.07.03","article-title":"Inhibition of mitochondrial reactive oxygen species reduces high glucose-induced pyroptosis and ferroptosis in H9C2 cardiac myocytes","volume":"41","author":"Wang","year":"2021","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-111","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/ctm2.13","article-title":"NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases","volume":"10","author":"Wang","year":"2020","journal-title":"Clinical and Translational Medicine"},{"issue":"12","key":"10.7717\/peerj.14952\/ref-112","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.1111\/jcmm.15318","article-title":"Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2-related programmed cell death in an AMPK-dependent manner","volume":"24","author":"Wang","year":"2020","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.7717\/peerj.14952\/ref-113","doi-asserted-by":"publisher","first-page":"3379883","DOI":"10.1155\/2022\/3379883","article-title":"Integrated Bioinformatics-Based Identification of Ferroptosis-Related Genes in Carotid Atherosclerosis","volume":"2022","author":"Wei","year":"2022","journal-title":"Disease Markers"},{"issue":"7","key":"10.7717\/peerj.14952\/ref-114","doi-asserted-by":"publisher","first-page":"4880","DOI":"10.1007\/s12035-018-1403-3","article-title":"Ferroptosis and its role in diverse brain diseases","volume":"56","author":"Weiland","year":"2019","journal-title":"Molecular Neurobiology"},{"issue":"26","key":"10.7717\/peerj.14952\/ref-115","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.3748\/wjg.14.4101","article-title":"Mechanisms of heme iron absorption: current questions and controversies","volume":"14","author":"West","year":"2008","journal-title":"World Journal of Gastroenterology"},{"issue":"6","key":"10.7717\/peerj.14952\/ref-116","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1080\/15548627.2022.2040314","article-title":"A new role of the early endosome in restricting NLRP3 inflammasome via mitophagy","volume":"18","author":"Wu","year":"2022","journal-title":"Autophagy"},{"key":"10.7717\/peerj.14952\/ref-117","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ijcard.2022.05.025","article-title":"PINK1\/Parkin-mediated mitophagy in cardiovascular disease: from pathogenesis to novel therapy","volume":"361","author":"Wu","year":"2022","journal-title":"International Journal of Cardiology"},{"issue":"9","key":"10.7717\/peerj.14952\/ref-118","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1080\/15548627.2016.1193656","article-title":"FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy","volume":"12","author":"Wu","year":"2016","journal-title":"Autophagy"},{"key":"10.7717\/peerj.14952\/ref-119","doi-asserted-by":"publisher","first-page":"127807","DOI":"10.1016\/j.jhazmat.2021.127807","article-title":"Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1alpha\/HO-1 signaling pathway in mouse testes","volume":"426","author":"Wu","year":"2022","journal-title":"Journal of Hazardous Materials"},{"key":"10.7717\/peerj.14952\/ref-120","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.2147\/DDDT.S248628","article-title":"Melatonin attenuates anoxia\/reoxygenation injury by inhibiting excessive mitophagy through the MT2\/SIRT3\/FoxO3a signaling pathway in H9c2 Cells","volume":"14","author":"Wu","year":"2020","journal-title":"Drug Design, Development and Therapy"},{"key":"10.7717\/peerj.14952\/ref-121","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3389\/fphar.2020.00452","article-title":"Gerontoxanthone I and macluraxanthone induce mitophagy and attenuate ischemia\/reperfusion injury","volume":"11","author":"Xiang","year":"2020","journal-title":"Frontiers in Pharmacology"},{"key":"10.7717\/peerj.14952\/ref-122","doi-asserted-by":"publisher","first-page":"110148","DOI":"10.1016\/j.biopha.2020.110148","article-title":"Electroacupuncture preconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting mitophagy mediated by the mTORC1-ULK1-FUNDC1 pathway","volume":"127","author":"Xiao","year":"2020","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-123","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death & Differentiation"},{"issue":"12","key":"10.7717\/peerj.14952\/ref-124","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.19540\/j.cnki.cjcmm.20200224.402","article-title":"Salvianolic acid B regulates mitochondrial autophagy mediated by NIX toprotect H9c2 cardiomyocytes from hypoxia\/reoxygenation injury","volume":"45","author":"Xin","year":"2020","journal-title":"China Jouranl of Chinese Materia Medica"},{"issue":"8","key":"10.7717\/peerj.14952\/ref-125","doi-asserted-by":"publisher","first-page":"4900","DOI":"10.1111\/jcmm.14511","article-title":"Molecular mechanisms of ferroptosis and its role in cancer therapy","volume":"23","author":"Xu","year":"2019","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.7717\/peerj.14952\/ref-126","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2020.09.015","article-title":"PINK1-mediated mitophagy protects against hepatic ischemia\/reperfusion injury by restraining NLRP3 inflammasome activation","volume":"160","author":"Xu","year":"2020","journal-title":"Free Radical Biology and Medicine"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-127","doi-asserted-by":"publisher","first-page":"10924","DOI":"10.1080\/21655979.2021.1995994","article-title":"Naringenin alleviates myocardial ischemia\/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2)\/System xc-\/glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis","volume":"12","author":"Xu","year":"2021","journal-title":"Bioengineered"},{"key":"10.7717\/peerj.14952\/ref-128","doi-asserted-by":"publisher","first-page":"793829","DOI":"10.3389\/fphar.2021.793829","article-title":"Mesenchymal stem cells alleviate post-resuscitation cardiac and cerebral injuries by inhibiting cell pyroptosis and ferroptosis in a swine model of cardiac arrest","volume":"12","author":"Xu","year":"2021","journal-title":"Frontiers in Pharmacology"},{"issue":"11","key":"10.7717\/peerj.14952\/ref-129","first-page":"69","article-title":"Carvacrol reduces myocardial ischemia-reperfusion injury by activating PTEN induced putative Kinase 1\/Parkin-mediated autophagy: animal and cell experiments","volume":"29","author":"Yan","year":"2021","journal-title":"Journal of Practical Cardiocerebral Pulmonary Vasculopathy"},{"issue":"2","key":"10.7717\/peerj.14952\/ref-130","doi-asserted-by":"publisher","first-page":"419","DOI":"10.14336\/AD.2019.0518","article-title":"Role of mitophagy in cardiovascular disease","volume":"11","author":"Yang","year":"2020","journal-title":"Aging and Disease"},{"issue":"9","key":"10.7717\/peerj.14952\/ref-131","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.bbadis.2019.05.007","article-title":"Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury","volume":"1865","author":"Yang","year":"2019","journal-title":"Biochimica et Biophysica Acta\u2014Molecular Basis of Disease"},{"issue":"1\u20132","key":"10.7717\/peerj.14952\/ref-132","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-133","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chemistry & Biology"},{"issue":"07","key":"10.7717\/peerj.14952\/ref-134","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/s11655-019-3166-8","article-title":"Tongxinluo ameliorates myocardial ischemia-reperfusion injury mainly via activating Parkin-mediated mitophagy and downregulating ubiquitin-proteasome system","volume":"27","author":"Yang","year":"2021","journal-title":"Chinese Journal of Integrative Medicine"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-135","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/jcmm.13008","article-title":"Ferroptosis, a new form of cell death, and its relationships with tumourous diseases","volume":"21","author":"Yu","year":"2017","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.7717\/peerj.14952\/ref-136","doi-asserted-by":"publisher","first-page":"111245","DOI":"10.1016\/j.mad.2020.111245","article-title":"Mitophagy in cardiovascular homeostasis","volume":"188","author":"Zhang","year":"2020","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.7717\/peerj.14952\/ref-137","doi-asserted-by":"publisher","first-page":"109464","DOI":"10.1016\/j.biopha.2019.109464","article-title":"HIF-1alpha\/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury","volume":"120","author":"Zhang","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"45","key":"10.7717\/peerj.14952\/ref-138","doi-asserted-by":"publisher","first-page":"53671","DOI":"10.1021\/acsami.1c18061","article-title":"Targeting ferroptosis by polydopamine nanoparticles protects heart against ischemia\/reperfusion injury","volume":"13","author":"Zhang","year":"2021","journal-title":"ACS Applied Materials & Interfaces"},{"issue":"1","key":"10.7717\/peerj.14952\/ref-139","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s42255-019-0162-4","article-title":"High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy","volume":"2","author":"Zhang","year":"2020","journal-title":"Nature Metabolism"},{"issue":"7","key":"10.7717\/peerj.14952\/ref-140","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.bbadis.2018.08.030","article-title":"Role of iron metabolism in heart failure: from iron deficiency to iron overload","volume":"1865","author":"Zhang","year":"2019","journal-title":"Biochimica et Biophysica Acta\u2014Molecular Basis of Disease"},{"issue":"03","key":"10.7717\/peerj.14952\/ref-141","first-page":"60","article-title":"Effect of astragalosideIV and Ginsenoside Rg1 on autophagy of myocardialTissue injury induced by ischemia-reperfusion injury in hyperlipidemic mice","volume":"38","author":"Zhang","year":"2020","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"issue":"6","key":"10.7717\/peerj.14952\/ref-142","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1007\/s12035-020-02277-7","article-title":"New Insights into the role of ferritin in iron homeostasis and neurodegenerative diseases","volume":"58","author":"Zhang","year":"2021","journal-title":"Molecular Neurobiology"},{"key":"10.7717\/peerj.14952\/ref-143","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bioactmat.2021.06.006","article-title":"Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries","volume":"7","author":"Zhao","year":"2022","journal-title":"Bioactive Materials"},{"key":"10.7717\/peerj.14952\/ref-144","doi-asserted-by":"publisher","first-page":"9929687","DOI":"10.1155\/2021\/9929687","article-title":"Ferroptosis: opportunities and challenges in myocardial ischemia-reperfusion injury","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"5","key":"10.7717\/peerj.14952\/ref-145","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3892\/mmr.2021.11991","article-title":"HIF1alpha in myocardial ischemiareperfusion injury (Review)","volume":"23","author":"Zheng","year":"2021","journal-title":"Molecular Medicine Reports"},{"issue":"6","key":"10.7717\/peerj.14952\/ref-146","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metabolism"},{"issue":"4","key":"10.7717\/peerj.14952\/ref-147","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.bbrc.2019.06.070","article-title":"Typhaneoside prevents acute myeloid leukemia (AML) through suppressing proliferation and inducing ferroptosis associated with autophagy","volume":"516","author":"Zhu","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.7717\/peerj.14952\/ref-148","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3389\/fphar.2020.00367","article-title":"Berberine protects against simulated ischemia\/reperfusion injury-induced H9C2 cardiomyocytes apoptosis in vitro and myocardial ischemia\/reperfusion-induced apoptosis in vivo by regulating the mitophagy-mediated HIF-1alpha\/BNIP3 pathway","volume":"11","author":"Zhu","year":"2020","journal-title":"Frontiers in Pharmacology"},{"issue":"7","key":"10.7717\/peerj.14952\/ref-149","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","article-title":"Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes","volume":"192","author":"Zorov","year":"2000","journal-title":"Journal of Experimental Medicine"},{"issue":"3","key":"10.7717\/peerj.14952\/ref-150","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiological Reviews"}],"container-title":["PeerJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/peerj.com\/articles\/14952.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/14952.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/14952.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/14952.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:35:23Z","timestamp":1678685723000},"score":1,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/14952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":150,"alternative-id":["10.7717\/peerj.14952"],"URL":"https:\/\/doi.org\/10.7717\/peerj.14952","archive":["CLOCKSS","LOCKSS","Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.7287\/peerj.14952v0.2\/reviews\/2","asserted-by":"object"},{"id-type":"doi","id":"10.7287\/peerj.14952v0.2\/reviews\/1","asserted-by":"object"},{"id-type":"doi","id":"10.7287\/peerj.14952v0.1\/reviews\/1","asserted-by":"object"},{"id-type":"doi","id":"10.7287\/peerj.14952v0.1\/reviews\/2","asserted-by":"object"}]},"ISSN":["2167-8359"],"issn-type":[{"value":"2167-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"article-number":"e14952"}}