{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:14:56Z","timestamp":1791476096107,"version":"4.3.4"},"reference-count":81,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2022M713535"],"award-info":[{"award-number":["2022M713535"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperthermic intraperitoneal chemotherapy (HIPEC) produces unwanted side-effects that are mainly caused by chemotherapeutic drugs in the treatment of gastrointestinal (GI) cancers, and these effects have not been systematically summarized. The aim of this article was to provide a comprehensive overview of the side-effects of HIPEC for GI cancers and propose practical strategies for adverse event management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>PubMed, Web of Science, and the Cochrane Library were systematically searched for side-effects of HIPEC in GI cancers prior to October 20, 2022. A total of 79 articles were included in this review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adverse events, such as enterocutaneous digestive fistulas, GI tract perforation, neutropenia, postoperative bleeding, ventricular tachycardia, hyperglycemia, hypocalcemia, renal impairment, encapsulating peritoneal sclerosis, scrotal ulceration, and sarcopenia were described, and their clinical management was discussed. These side-effects involve the digestive, hematopoietic, circulatory, metabolic, and urinary systems. Effective methods for adverse event management included an expert multidisciplinary team, replacing chemotherapy drugs, using Chinese medicine, and careful preoperative assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The side-effects of HIPEC are frequent and can be minimized by several effective methods. This study proposes practical strategies for adverse event management of HIPEC to assist physicians in choosing the optimal treatment method.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.15277","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T04:24:30Z","timestamp":1682655870000},"page":"e15277","source":"Crossref","is-referenced-by-count":13,"title":["Side-effects of hyperthermic intraperitoneal chemotherapy in patients with gastrointestinal cancers"],"prefix":"10.7717","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-2677","authenticated-orcid":true,"given":"Jiyun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Haikou People\u2019s Hospital\/Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-3637","authenticated-orcid":true,"given":"Shucai","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Hepatobiliary Surgery, Haikou People\u2019s Hospital\/Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"issue":"1","key":"10.7717\/peerj.15277\/ref-1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s12029-014-9665-0","article-title":"Scrotal pain and ulceration post HIPEC: a case report","volume":"46","author":"Abdul Aziz","year":"2015","journal-title":"Journal of Gastrointestinal Cancer"},{"issue":"1","key":"10.7717\/peerj.15277\/ref-2","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12957-016-1047-6","article-title":"Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC","volume":"15","author":"Abel","year":"2017","journal-title":"World Journal of Surgical 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