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It has been posited that traits shared by nonclinical individuals and psychiatric patients could help explain the pathogenesis of compulsive decision-making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate whether cognitive inflexibility predisposes nonclinical individuals to poor choices and hyper-reactivity to reward, we recruited people with high and low scores for cognitive persistence and used the Iowa Gambling Task to assess decision-making and cardiac reactivity to monetary gains\/losses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As is frequently observed in psychophysiological research, the data indicated discrepancies among self-reports, behavior, and physiology. Cognitive inflexibility was not related to worse performance; however, monetary gains, in line with the literature, prompted marked cardiac accelerations. Consistent with our research goal, only inflexible participants showed large cardiac accelerations during the largest monetary wins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Taken together, the data confirm an association between cognitive persistence and physiological reward sensitivity in a nonclinical population. The findings are in line with recent theories on the development of compulsive behaviors that consider cognitive inflexibility as a transdiagnostic impairment and predisposing factor for excessive reactivity to rewards, and might act both as a preexisting individual trait and drug-induced deficit.<\/jats:p><\/jats:sec>","DOI":"10.7717\/peerj.15318","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T07:46:30Z","timestamp":1683531990000},"page":"e15318","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac sensitivity to rewards in cognitively inflexible nonclinical participants"],"prefix":"10.7717","volume":"11","author":[{"given":"Jos\u00e9 Luis","family":"Mata","sequence":"first","affiliation":[{"name":"Department of Personality, Evaluation and Psychological Treatment, University of Granada, Granada, Andaluc\u00eda, 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