{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:48:32Z","timestamp":1772268512624,"version":"3.50.1"},"reference-count":23,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The research grant from Otis Glebe Medical Foundation Nebraska University Foundation","award":["#01100674"],"award-info":[{"award-number":["#01100674"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Stereotactic radiosurgery (SRS) and fractionated stereotactic radiation therapy (SRT) are both treatments shown to be effective in treating brain metastases (BMs). However, it is unknown how these treatments compare in effectiveness and safety in cancer patients with BMs regardless of the primary cancer. The main objective of this study is to investigate the SRS and SRT treatments\u2019 associations with the overall survival (OS) of patients diagnosed with BMs using the National Cancer Database (NCDB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Patients in the NCDB with breast cancer, non-small cell lung cancer, small cell lung cancer, other lung cancers, melanoma, colorectal cancer, or kidney cancer who had BMs at the time of their primary cancer diagnosis and received either SRS or SRT as treatment for their BMs were included in the study. We analyzed OS with a Cox proportional hazard analysis that adjusted variables associated with improved OS during univariable analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the total 6,961 patients that fit the criteria for the study, 5,423 (77.9%) received SRS and 1,538 (22.1%) received SRT. Patients who received SRS treatment had a median survival time of 10.9 (95% CI [10.5\u201311.3]), and those who received SRT treatment had a median survival time of 11.3 (95% CI [10.4\u201312.3]) months. This difference was not found to be significant (Log-rank\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.31). Multivariable Cox proportional hazard analysis did not yield a significant difference between the treatments\u2019 associations with OS (Hazard Ratio: 0.942, CI 95% [0.882\u20131.006];\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.08) or SRS\n                      <jats:italic>vs.<\/jats:italic>\n                      SRT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this analysis, SRS and SRT did not show a significant difference in their associations with OS. Future studies investigating the neurotoxicity risks of SRS as compared to SRT are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.15357","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:55:12Z","timestamp":1684468512000},"page":"e15357","source":"Crossref","is-referenced-by-count":5,"title":["Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site"],"prefix":"10.7717","volume":"11","author":[{"given":"Garett Paul","family":"Ostdiek-Wille","sequence":"first","affiliation":[{"name":"College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saber","family":"Amin","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Lin","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States of 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