{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:35:09Z","timestamp":1791956109226,"version":"4.3.4"},"reference-count":32,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine, Khon Kaen University, Thailand","award":["IN63221"],"award-info":[{"award-number":["IN63221"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Carpal tunnel syndrome (CTS) is a prevalent entrapment neuropathy resulting in hand pain, numbness and\/or weakness, which significantly impairs hand function in daily activities. Repetitive peripheral magnetic stimulation (rPMS) is a potential therapeutic option for focal peripheral nerve disease and may be beneficial for CTS treatment. We aimed to compare the effects of rPMS and conventional therapy in the management of CTS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A blinded assessor randomly assigned 24 participants with electrodiagnostically-confirmed mild or moderate CTS to either rPMS or conventional therapy. Both groups were briefed on disease progression and tendon-gliding exercises. In the intervention group, the rPMS protocol, five sessions of rPMS\u2014with a frequency of 10 Hz, 10 pulses\/train, and 100 trains\/session\u2014were performed over a period of 2 weeks, with three sessions in the first week and two sessions in the second week. At baseline and the end of the second week, the Boston Carpal Tunnel Questionnaire, pinch strength, and electrodiagnostic results were evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The rPMS group demonstrated significantly greater within-group improvement in symptom severity scores (2.3 <jats:italic>vs<\/jats:italic>. 1.6, <jats:italic>p<\/jats:italic> = 0.009) and pinch strength (10.6 lbs <jats:italic>vs<\/jats:italic>. 13.8 lbs, <jats:italic>p<\/jats:italic> &lt; 0.001). Regarding electrodiagnostic parameters, sensory nerve action potential (SNAP) amplitude was significantly increased (8.7 \u00b5V <jats:italic>vs<\/jats:italic>. 14.3 \u00b5V, <jats:italic>p<\/jats:italic> = 0.002) within the group treated with rPMS. With conventional therapy, there were no statistically significant within-group differences. Multiple linear regression models showed that there were no significant differences in other outcomes in between-group comparisons.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Five sessions of rPMS resulted in significant reduction in symptom severity, improvement in pinch strength and increase in SNAP amplitude. Future research should investigate the clinical utility of rPMS using a larger sample and longer treatment and follow-up durations.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.15398","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T07:01:57Z","timestamp":1684393317000},"page":"e15398","source":"Crossref","is-referenced-by-count":8,"title":["Effects of repetitive peripheral magnetic stimulation <i>vs<\/i>. conventional therapy in the management of carpal tunnel syndrome: a pilot randomized controlled trial"],"prefix":"10.7717","volume":"11","author":[{"given":"Arachaphon","family":"Panathoop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-9735","authenticated-orcid":true,"given":"Jittima","family":"Saengsuwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratana","family":"Vichiansiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"10.7717\/peerj.15398\/ref-1","first-page":"6","article-title":"Carpal tunnel syndrome","volume":"77","author":"Aroori","year":"2008","journal-title":"Ulster Medical Journal"},{"issue":"1","key":"10.7717\/peerj.15398\/ref-2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.32598\/irjns.6.1.4","article-title":"Revisiting the urge to operate: one-year neurophysiological follow-up in severe CTS","volume":"6","author":"Ashraf","year":"2020","journal-title":"Iranian Journal of Neurosurgery"},{"issue":"2","key":"10.7717\/peerj.15398\/ref-3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/jama.282.2.153","article-title":"Prevalence of carpal tunnel syndrome in a general population","volume":"282","author":"Atroshi","year":"1999","journal-title":"JAMA"},{"issue":"1","key":"10.7717\/peerj.15398\/ref-4","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1186\/s12891-018-1948-3","article-title":"Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized controlled trial","volume":"19","author":"Atthakomol","year":"2018","journal-title":"BMC Musculoskeletal Disorders"},{"issue":"3","key":"10.7717\/peerj.15398\/ref-5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neucli.2015.08.002","article-title":"Repetitive peripheral magnetic stimulation to reduce pain or improve sensorimotor impairments: a literature review on parameters of application and afferents recruitment","volume":"45","author":"Beaulieu","year":"2015","journal-title":"Neurophysiologie Clinique-Clinical Neurophysiology"},{"key":"10.7717\/peerj.15398\/ref-6","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/(ISSN)1531-8249","article-title":"Increase in hand muscle strength of stroke patients after somatosensory stimulation","volume":"51","author":"Conforto","year":"2002","journal-title":"Annals of Neurology"},{"issue":"12","key":"10.7717\/peerj.15398\/ref-7","doi-asserted-by":"publisher","first-page":"e434","DOI":"10.1016\/j.clinph.2017.09.089","article-title":"82. 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