{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:20:49Z","timestamp":1781871649175,"version":"3.54.5"},"reference-count":36,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["2020J011087 and 2022J01121025"],"award-info":[{"award-number":["2020J011087 and 2022J01121025"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Innovation Project of Fujian Provincial Health Commission","award":["2020CXA006"],"award-info":[{"award-number":["2020CXA006"]}]},{"name":"Zhuhai Science and Technology Project","award":["20171009E030078"],"award-info":[{"award-number":["20171009E030078"]}]},{"name":"Startup Fund for Scientific Research of Fujian Medical University","award":["2020QH1258"],"award-info":[{"award-number":["2020QH1258"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Background and aim<\/jats:title>\n<jats:p>Efficacy of <jats:italic>Helicobacter pylori (H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>) eradication is related to the local antimicrobial resistance epidemiology. We aimed to investigate the antibiotic resistance of <jats:italic>H. pylori<\/jats:italic> in Fujian, China.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p><jats:italic>H. pylori<\/jats:italic>-infected patients in four centers were enrolled in the study from Oct 2019 to Jan 2022. The bacteria were isolated, cultured and identified from the biopsy of patients\u2019 gastric mucosa samples. Antimicrobial susceptibility testing was performed by a modified broth microdilution method for <jats:italic>H. pylori<\/jats:italic> to seven guideline-recommended antibiotics and seven potential choices for <jats:italic>H. pylori<\/jats:italic> eradication.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 205 <jats:italic>H. pylori<\/jats:italic> strains were isolated. The resistance rates of amoxicillin (AMX), amoxicillin and clavulanate potassium (AMC), cefixime (CFM), gentamicin (GEN), tetracycline (TET), doxycycline (DOX), azithromycin (AZM), clarithromycin (CLR), levofloxacin (LVFX), sparfloxacin (SPFX), metronidazole (MTZ), tinidazole (TID), rifampicin (RFP) and furazolidone (FZD) were 11.22%, 12.20%, 7.32%, 12.20%, 4.88%, 4.39%, 44.39%, 43.90%, 30.24%, 21.46%, 40.98%, 45.85%, 5.37% and 10.24%, respectively. The rates of pan-sensitivity, single, double, triple and multiple resistance for seven guideline-recommended antibiotics were 32.68%, 30.24%, 13.17%, 7.76%, and 14.15%, respectively. The main double-resistance patterns were CLR+MTZ (10\/205, 5%) and CLR+LVFX (9\/205, 4%). The main triple-resistance pattern was CLR+MTZ+ LVFX (15\/205, 7%).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In Fujian, the prevalence of <jats:italic>H. pylori<\/jats:italic> resistance to AZM, CLR, LVFX, SPFX, MTZ, and TID was high, whereas that to AMX, AMC, GEN, CFM, TET, DOX, RFP and FZD was relatively low. CFM and DOX are promising new choices for <jats:italic>H. pylori<\/jats:italic> eradication.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.15611","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T08:38:40Z","timestamp":1689064720000},"page":"e15611","source":"Crossref","is-referenced-by-count":10,"title":["Antibiotic resistance profile of <i>Helicobacter pylori<\/i> to 14 antibiotics: a multicenter study in Fujian, China"],"prefix":"10.7717","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-2277","authenticated-orcid":true,"given":"Xueping","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China"},{"name":"Department of Gastroenterology, Fujian Provincial Hospital, Fuzhou, Fujian, 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