{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:03:31Z","timestamp":1791414211245,"version":"4.3.3"},"reference-count":57,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Natural Science Foundation of Sichuan Province","award":["2022NSFSC1482"],"award-info":[{"award-number":["2022NSFSC1482"]}]},{"name":"The Natural Science Foundation of Sichuan Province","award":["2023NSFSC1509"],"award-info":[{"award-number":["2023NSFSC1509"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Uncertainty exists regarding the pain scores and the success rate of intraligamentary anesthesia compared to other infiltration anesthesia. Based on the conditions of clinical anesthesia techniques, we conducted a systematic review and meta-analysis to compare the efficacy of intraligamentary anesthesia with other infiltration anesthesia.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>The search was carried out in PubMed Central, Cochrane Central Register of Controlled Trials, MEDLINE (via OVID), Embase (via OVID), and Scopus from the inception to March 26, 2023.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>Seven eligible randomized controlled trials were included in the meta-analysis. The results indicated no significant difference in the success rate (RR = 0.96; 95% CI [0.81\u20131.14]; <jats:italic>p<\/jats:italic> = 0.65; I<jats:sup>2<\/jats:sup>= 73%) and visual analog scale (VAS) during dental procedures (MD = 3.81; 95% CI [\u22120.54\u20138.16]; <jats:italic>p<\/jats:italic> = 0.09; I<jats:sup>2<\/jats:sup>= 97%) between intraligamentary anesthesia and other infiltration anesthesia. However, intraligamentary anesthesia exhibited a higher VAS score during injection than other infiltration anesthesia (MD = 8.83; 95% CI [4.86\u201312.79]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; I<jats:sup>2<\/jats:sup>= 90%). A subgroup analysis according to infiltration techniques showed that supraperiosteal anesthesia had a lower VAS score during dental procedures than intraligamentary anesthesia.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusions<\/jats:title>\n               <jats:p>Intraligamentary anesthesia and other infiltration anesthesias have the same success rate and pain during dental procedures. However, the pain during injection of intraligamentary anesthesia is heavier than that of other infiltration anesthesia.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.15734","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T08:13:12Z","timestamp":1690186392000},"page":"e15734","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of dental anesthetic efficacy between the periodontal intraligamentary anesthesia and other infiltration anesthesia: a systematic review and meta-analysis"],"prefix":"10.7717","volume":"11","author":[{"given":"Jialei","family":"Pan","sequence":"first","affiliation":[{"name":"Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuran","family":"Qian","sequence":"additional","affiliation":[{"name":"Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[{"name":"Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan University, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"10.7717\/peerj.15734\/ref-1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/sj.bdj.4806044","article-title":"The use of intraligamental injections in haemophiliacs","volume":"162","author":"Ah\u00a0Pin","year":"1987","journal-title":"British Dental Journal"},{"key":"10.7717\/peerj.15734\/ref-2","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.2147\/tcrm.S143173","article-title":"Periodontal ligament injection versus routine local infiltration for nonsurgical single posterior maxillary permanent tooth extraction: comparative double-blinded randomized clinical study","volume":"13","author":"Al-Shayyab","year":"2017","journal-title":"Therapeutics and Clinical Risk Management"},{"key":"10.7717\/peerj.15734\/ref-3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.17245\/jdapm.2018.18.6.319","article-title":"Efficacy of dental local anesthetics: a review","volume":"18","author":"Badr","year":"2018","journal-title":"Journal of Dental Anesthesia and Pain Medicine"},{"key":"10.7717\/peerj.15734\/ref-4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.17245\/jdapm.2018.18.4.197","article-title":"Computerized intraligamental anesthesia in children: a review of clinical considerations","volume":"18","author":"Baghlaf","year":"2018","journal-title":"Journal of Dental Anesthesia and Pain Medicine"},{"key":"10.7717\/peerj.15734\/ref-5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.annemergmed.2007.04.021","article-title":"Comparison of four pain scales in children with acute abdominal pain in a pediatric emergency department","volume":"50","author":"Bailey","year":"2007","journal-title":"Annals of Emergency Medicine"},{"key":"10.7717\/peerj.15734\/ref-6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00784-012-0724-2","article-title":"Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine + epinephrine delivery: a dose-finding study","volume":"17","author":"Biocanin","year":"2013","journal-title":"Clinical Oral Investigations"},{"key":"10.7717\/peerj.15734\/ref-7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/bja\/aen103","article-title":"Assessment of pain","volume":"101","author":"Breivik","year":"2008","journal-title":"British Journal of Anaesthesia"},{"key":"10.7717\/peerj.15734\/ref-8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00784-009-0352-7","article-title":"Intraseptal vs. periodontal ligament anaesthesia for maxillary tooth extraction: quality of local anaesthesia and haemodynamic response","volume":"14","author":"Brkovic","year":"2010","journal-title":"Clinical Oral Investigations"},{"key":"10.7717\/peerj.15734\/ref-9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(83)90088-x","article-title":"Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale","volume":"16","author":"Carlsson","year":"1983","journal-title":"Pain"},{"key":"10.7717\/peerj.15734\/ref-10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.coms.2007.01.008v","article-title":"Anesthetic issues and anxiety management in the female oral and maxillofacial surgery patient","volume":"19","author":"Crowley","year":"2007","journal-title":"Oral and Maxillofacial Surgery Clinics of North America"},{"key":"10.7717\/peerj.15734\/ref-11","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ijom.2019.10.017","article-title":"Intraligamentary anaesthesia as a possible anaesthetic option in oral implantology: a retrospective analysis","volume":"49","author":"Dalla\u00a0Torre","year":"2020","journal-title":"International Journal of Oral and Maxillofacial Surgery"},{"key":"10.7717\/peerj.15734\/ref-12","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.7717\/peerj.15734\/ref-13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1037\/a0035747","article-title":"Cognitive-behavioral therapy for individuals with chronic pain: efficacy, innovations, and directions for research","volume":"69","author":"Ehde","year":"2014","journal-title":"The American Psychologist"},{"key":"10.7717\/peerj.15734\/ref-14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.17796\/1053-4628-40.3.193","article-title":"Intraligamentary and supraperiosteal anesthesia efficacy using a computer controlled delivery system in mandibular molars","volume":"40","author":"Elbay","year":"2016","journal-title":"The Journal of Clinical Pediatric Dentistry"},{"key":"10.7717\/peerj.15734\/ref-15","doi-asserted-by":"publisher","first-page":"e89\u2013e93","DOI":"10.1016\/j.tripleo.2009.06.012","article-title":"Anesthetic efficacy of inferior alveolar nerve block plus buccal infiltration or periodontal ligament injections with articaine in patients with irreversible pulpitis in the mandibular first molar","volume":"108","author":"Fan","year":"2009","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"key":"10.7717\/peerj.15734\/ref-16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2344\/0003-3006(2007)54[163:Aeobal]2.0.Co;2","article-title":"Anesthetic efficacy of buccal and lingual infiltrations of lidocaine following an inferior alveolar nerve block in mandibular posterior teeth","volume":"54","author":"Foster","year":"2007","journal-title":"Anesthesia Progress"},{"key":"10.7717\/peerj.15734\/ref-17","doi-asserted-by":"publisher","first-page":"Cd006487","DOI":"10.1002\/14651858.CD006487.pub2","article-title":"Injectable local anaesthetic agents for dental anaesthesia","volume":"7","author":"George","year":"2018","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"10.7717\/peerj.15734\/ref-18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17245\/jdapm.2022.22.1.1","article-title":"Anesthetic efficacy of supplemental intraligamentary injection in human mandibular teeth with irreversible pulpitis: a systematic review and meta-analysis","volume":"22","author":"Gupta","year":"2022","journal-title":"Journal of Dental Anesthesia and Pain Medicine"},{"key":"10.7717\/peerj.15734\/ref-19","first-page":"217","article-title":"Lack of differential effect by Ultracaine (articaine) and Citanest (prilocaine) in infiltration anaesthesia","volume":"57","author":"Haas","year":"1991","journal-title":"Journal (Canadian Dental Association)"},{"key":"10.7717\/peerj.15734\/ref-20","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12903-022-02194-2","article-title":"Computer-controlled Intraligamentary local anaesthesia in extraction of mandibular primary molars: randomised controlled clinical trial","volume":"22","author":"Helmy","year":"2022","journal-title":"BMC Oral Health"},{"key":"10.7717\/peerj.15734\/ref-21","article-title":"Cochrane handbook for systematic reviews of interventions version 6.2 (updated 2022): Cochrane, 2022","author":"Higgins","year":"2022"},{"key":"10.7717\/peerj.15734\/ref-22","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.jpainsymman.2010.08.016","article-title":"Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review","volume":"41","author":"Hjermstad","year":"2011","journal-title":"Journal of Pain and Symptom Management"},{"key":"10.7717\/peerj.15734\/ref-23","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.5005\/jp-journals-10024-2391","article-title":"Comparative evaluation of the efficacy of intraligamentary and supraperiosteal injections in the extraction of maxillary teeth: a randomized controlled clinical trial","volume":"19","author":"Jain","year":"2018","journal-title":"The Journal of Contemporary Dental Practice"},{"key":"10.7717\/peerj.15734\/ref-24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0304-3959(86)90228-9","article-title":"The measurement of clinical pain intensity: a comparison of six methods","volume":"27","author":"Jensen","year":"1986","journal-title":"Pain"},{"key":"10.7717\/peerj.15734\/ref-25","doi-asserted-by":"publisher","first-page":"122","DOI":"10.2344\/0003-3006(2005)52[122:Asp]2.0.Co;2","article-title":"A survey of pain, pressure, and discomfort induced by commonly used oral local anesthesia injections","volume":"52","author":"Kaufman","year":"2005","journal-title":"Anesthesia Progress"},{"key":"10.7717\/peerj.15734\/ref-26","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1067\/moe.2001.114000","article-title":"Anesthetic efficacy of ropivacaine in maxillary anterior infiltration","volume":"91","author":"Kennedy","year":"2001","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"key":"10.7717\/peerj.15734\/ref-27","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/papr.12216","article-title":"Measuring the intensity of chronic pain: are the visual analogue scale and the verbal rating scale interchangeable?","volume":"15","author":"Kliger","year":"2015","journal-title":"Pain Practice"},{"key":"10.7717\/peerj.15734\/ref-28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.arcmed.2003.07.007","article-title":"Comparison of three rating scales for measuring subjective phenomena in clinical research. I. Use of experimentally controlled auditory stimuli","volume":"35","author":"Lara-Mu\u00f1oz","year":"2004","journal-title":"Archives of Medical Research"},{"key":"10.7717\/peerj.15734\/ref-29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.17245\/jdapm.2015.15.4.201","article-title":"Articaine (4%) with epinephrine (1:100, 000 or 1:200, 000) in inferior alveolar nerve block: effects on the vital signs and onset, and duration of anesthesia","volume":"15","author":"Lasemi","year":"2015","journal-title":"Journal of Dental Anesthesia and Pain Medicine"},{"key":"10.7717\/peerj.15734\/ref-30","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.tripleo.2007.03.015","article-title":"Cardiovascular influence of dental anxiety during local anesthesia for tooth extraction","volume":"105","author":"Liau","year":"2008","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics"},{"key":"10.7717\/peerj.15734\/ref-31","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/0030-4220(75)90028-6","article-title":"A clinical appraisal of intraosseous dental anesthesia","volume":"39","author":"Lilienthal","year":"1975","journal-title":"Oral Surgery, Oral Medicine, and Oral Pathology"},{"key":"10.7717\/peerj.15734\/ref-32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0030-4220(82)90273-0","article-title":"The periodontal ligament (PDL) injection: an alternative to inferior alveolar nerve block","volume":"53","author":"Malamed","year":"1982","journal-title":"Oral Surgery, Oral Medicine, and Oral Pathology"},{"key":"10.7717\/peerj.15734\/ref-33","first-page":"657","article-title":"Local anesthesia","volume":"26","author":"Malamed","year":"1998","journal-title":"Journal of the California Dental Association"},{"key":"10.7717\/peerj.15734\/ref-34","first-page":"109","article-title":"The periodontal ligament injection; a solitary method for inducing local anesthesia","volume":"31","author":"Mansour","year":"1985","journal-title":"Egyptian Dental Journal"},{"issue":"202","key":"10.7717\/peerj.15734\/ref-35","first-page":"204","article-title":"Intraseptal anesthesia in the general dental practice","volume":"8","author":"Marin","year":"1987","journal-title":"Compendium"},{"key":"10.7717\/peerj.15734\/ref-36","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0300-5712(92)90018-8","article-title":"Intraligamentary anaesthesia","volume":"20","author":"Meechan","year":"1992","journal-title":"Journal of Dentistry"},{"key":"10.7717\/peerj.15734\/ref-37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1046\/j.1365-2591.2002.00532.x","article-title":"Pulpal anaesthesia for mandibular central incisor teeth: a comparison of infiltration and intraligamentary injections","volume":"35","author":"Meechan","year":"2002","journal-title":"International Endodontic Journal"},{"key":"10.7717\/peerj.15734\/ref-38","doi-asserted-by":"publisher","first-page":"756","DOI":"10.14219\/jada.archive.1997.0301","article-title":"Four dimensions of fear of dental injections","volume":"128","author":"Milgrom","year":"1997","journal-title":"Journal of the American Dental Association"},{"key":"10.7717\/peerj.15734\/ref-39","first-page":"639","article-title":"A clinical evaluation of the Ligmaject periodontal ligament injection syringe","volume":"10","author":"Miller","year":"1983","journal-title":"Dental Update"},{"key":"10.7717\/peerj.15734\/ref-40","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/anae.12148","article-title":"Pain measures and cut-offs\u2014\u2018no worse than mild pain\u2019 as a simple, universal outcome","volume":"68","author":"Moore","year":"2013","journal-title":"Anaesthesia"},{"key":"10.7717\/peerj.15734\/ref-41","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cden.2009.12.003","article-title":"Local anesthesia strategies for the patient with a hot tooth","volume":"54","author":"Nusstein","year":"2010","journal-title":"Dental Clinics of North America"},{"key":"10.7717\/peerj.15734\/ref-42","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/ptj\/84.6.560","article-title":"The measurement of pain in infants, children, and adolescents: from policy to practice","volume":"84","author":"O\u2019Rourke","year":"2004","journal-title":"Physical Therapy"},{"key":"10.7717\/peerj.15734\/ref-43","first-page":"130","article-title":"The assessment of pain sensation during local anesthesia using a computerized local anesthesia (Wand) and a conventional syringe","volume":"70","author":"Ram","year":"2003","journal-title":"Journal of Dentistry for Children"},{"key":"10.7717\/peerj.15734\/ref-44","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/jcph.250","article-title":"Assessing pain intensity with the visual analog scale: a plea for uniformity","volume":"54","author":"Reed","year":"2014","journal-title":"Journal of Clinical Pharmacology"},{"key":"10.7717\/peerj.15734\/ref-45","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.2147\/jpr.S170324","article-title":"Efficacy of intraligamentary anesthesia in maxillary first molar extraction","volume":"11","author":"Ryalat","year":"2018","journal-title":"Journal of Pain Research"},{"key":"10.7717\/peerj.15734\/ref-46","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00784-013-1113-1","article-title":"Periodontal intraligament injection as alternative to inferior alveolar nerve block\u2014meta-analysis of the literature from 1979 to 2012","volume":"18","author":"Shabazfar","year":"2014","journal-title":"Clinical Oral Investigations"},{"key":"10.7717\/peerj.15734\/ref-47","doi-asserted-by":"publisher","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"10.7717\/peerj.15734\/ref-48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1754-4505.1988.tb00680.x","article-title":"Use of the periodontal ligament injection in dental care of the patient with hemophilia\u2014a clinical evaluation","volume":"8","author":"Spuller","year":"1988","journal-title":"Special Care in Dentistry"},{"key":"10.7717\/peerj.15734\/ref-49","first-page":"1020","article-title":"Effectiveness of intraligamental anesthesia in controlling the hyperesthesia during tooth preparation","volume":"10","author":"Subramaniam","year":"2018","journal-title":"Drug Invention Today"},{"key":"10.7717\/peerj.15734\/ref-50","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/s0304-3959(99)00299-7","article-title":"Simple pain rating scales hide complex idiosyncratic meanings","volume":"85","author":"Williams","year":"2000","journal-title":"Pain"},{"key":"10.7717\/peerj.15734\/ref-51","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.1365-2702.2005.01121.x","article-title":"Pain: a review of three commonly used pain rating scales","volume":"14","author":"Williamson","year":"2005","journal-title":"Journal of Clinical Nursing"},{"key":"10.7717\/peerj.15734\/ref-52","first-page":"9","article-title":"Pain in children: comparison of assessment scales","volume":"14","author":"Wong","year":"1988","journal-title":"Pediatric Nursing"},{"key":"10.7717\/peerj.15734\/ref-53","first-page":"418","article-title":"Intraseptal anesthesia: a review of a relevant injection technique","volume":"53","author":"Woodmansey","year":"2005","journal-title":"General Dentistry"},{"key":"10.7717\/peerj.15734\/ref-54","first-page":"64","article-title":"Medial pterygoid trismus (myospasm) following inferior alveolar nerve block: case report and literature review","volume":"59","author":"Wright","year":"2011","journal-title":"General Dentistry"},{"key":"10.7717\/peerj.15734\/ref-55","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1007\/s00784-023-04911-9","article-title":"Comparison of the effectiveness of intraligamentary anesthesia and inferior alveolar nerve block on mandibular molar teeth in pediatric patients: a randomized controlled clinical study","volume":"27","author":"Y\u0131lmaz","year":"2023","journal-title":"Clinical Oral Investigations"},{"key":"10.7717\/peerj.15734\/ref-56","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11916-009-0009-x","article-title":"Pain outcomes: a brief review of instruments and techniques","volume":"13","author":"Younger","year":"2009","journal-title":"Current Pain and Headache Reports"},{"key":"10.7717\/peerj.15734\/ref-57","doi-asserted-by":"publisher","first-page":"4825","DOI":"10.1007\/s00784-021-03787-x","article-title":"RCT on the effectiveness of the intraligamentary anesthesia and inferior alveolar nerve block on pain during dental treatment","volume":"25","author":"Youssef","year":"2021","journal-title":"Clinical Oral Investigations"}],"container-title":["PeerJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/peerj.com\/articles\/15734.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/15734.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/15734.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/15734.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T08:13:38Z","timestamp":1690186418000},"score":1,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/15734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":57,"alternative-id":["10.7717\/peerj.15734"],"URL":"https:\/\/doi.org\/10.7717\/peerj.15734","archive":["CLOCKSS","LOCKSS","Portico"],"relation":{},"ISSN":["2167-8359"],"issn-type":[{"value":"2167-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,24]]},"article-number":"e15734"}}