{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:35:14Z","timestamp":1762018514935},"reference-count":42,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82101391"],"award-info":[{"award-number":["82101391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Objective<\/jats:title>\n               <jats:p>To explore the effects of home-based telerehabilitation (TR) on dynamic alterations in regional intrinsic neural activity and degree centrality in stroke patients by resting-state functional MRI (fMRI) methods.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>The neuroimaging data of 52 stroke patients were analyzed. Dynamic regional spontaneous neural activity (dynamic amplitude of low-frequency fluctuations, dALFF; and dynamic regional homogeneity, dReHo) and dynamic degree centrality (dDC) were compared between the TR and conventional rehabilitation (CR) groups. A flexible factorial model was employed to investigate the expected effects.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>The patients in the TR group showed increased dALFF in the right precuneus and bilateral precentral gyrus (PreCG) and reduced dALFF in the right inferior parietal lobule by the analysis of main effects. Significant differences between groups were detected in the right precuneus, right fusiform gyrus and left middle frontal gyrus for dReHo and in the left cingulate gyrus, right middle temporal gyrus and left precuneus for dDC. A significant correlation was found in the TR group between the changed dALFF in the left PreCG and the changed Fugl-Meyer assessment (FMA) scores from baseline to postrehabilitation.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusions<\/jats:title>\n               <jats:p>This study implied that home-based TR training can alter the patterns of dynamic spontaneous brain activity and functional connectivity in certain brain regions. The identification of key brain regions by neuroimaging indicators such as dynamic regional brain activity and degree centrality in the recovery process would provide a theoretical basis for noninvasive brain stimulation technology and strategies for formulating targeted rehabilitation programs for stroke patients with motor dysfunction.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.15903","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:44:27Z","timestamp":1693554267000},"page":"e15903","source":"Crossref","is-referenced-by-count":7,"title":["Effects of home-based telerehabilitation on dynamic alterations in regional intrinsic neural activity and degree centrality in stroke patients"],"prefix":"10.7717","volume":"11","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglei","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Shanghai Fifth People\u2019s Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"10.7717\/peerj.15903\/ref-1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1093\/cercor\/bhs352","article-title":"Tracking whole-brain connectivity dynamics in the resting state","volume":"24","author":"Allen","year":"2014","journal-title":"Cerebral Cortex"},{"key":"10.7717\/peerj.15903\/ref-2","doi-asserted-by":"publisher","first-page":"D3437","DOI":"10.1002\/14651858.CD003437.pub4","article-title":"Pharmacological, psychological, and non-invasive brain stimulation interventions for treating depression after stroke","volume":"1","author":"Allida","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.7717\/peerj.15903\/ref-3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0140-6736(17)31584-2","article-title":"Unmet challenges for rehabilitation after stroke in China","volume":"390","author":"Asakawa","year":"2017","journal-title":"Lancet"},{"key":"10.7717\/peerj.15903\/ref-4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"10.7717\/peerj.15903\/ref-5","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"10.7717\/peerj.15903\/ref-6","doi-asserted-by":"publisher","first-page":"822253","DOI":"10.3389\/fneur.2022.822253","article-title":"The degree centrality and functional connectivity in patients with temporal lobe epilepsy presenting as ictal panic: a resting state fMRI study","volume":"13","author":"Chang","year":"2022","journal-title":"Frontiers in Neurology"},{"key":"10.7717\/peerj.15903\/ref-7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnsys.2010.00013","article-title":"DPARSF: a MATLAB toolbox for pipeline data analysis of resting-state fMRI","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Frontiers in Systems Neurosciences"},{"key":"10.7717\/peerj.15903\/ref-8","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/PHM.0000000000000559","article-title":"Effects of home-based telesupervising rehabilitation on physical function for stroke survivors with hemiplegia: a randomized controlled trial","volume":"96","author":"Chen","year":"2017","journal-title":"American Journal of Physical Medicine and Rehabilitation"},{"key":"10.7717\/peerj.15903\/ref-9","doi-asserted-by":"publisher","first-page":"e9605","DOI":"10.1097\/MD.0000000000009605","article-title":"Effectiveness and neural mechanisms of home-based telerehabilitation in patients with stroke based on fMRI and DTI: a study protocol for a randomized controlled trial","volume":"97","author":"Chen","year":"2018","journal-title":"Medicine"},{"key":"10.7717\/peerj.15903\/ref-10","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3389\/fnins.2018.00994","article-title":"Dynamic alterations in spontaneous neural activity in multiple brain networks in subacute stroke patients: a resting-state fMRI study","volume":"12","author":"Chen","year":"2018","journal-title":"Frontiers in Neurosciences"},{"key":"10.7717\/peerj.15903\/ref-11","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s11682-020-00266-x","article-title":"Altered static and dynamic voxel-mirrored homotopic connectivity in subacute stroke patients: a resting-state fMRI study","volume":"15","author":"Chen","year":"2020","journal-title":"Brain Imaging and Behavior"},{"key":"10.7717\/peerj.15903\/ref-12","doi-asserted-by":"publisher","first-page":"e2318-e2330","DOI":"10.1212\/WNL.0000000000010821","article-title":"Effects of home-based telerehabilitation in patients with stroke: a randomized controlled trial","volume":"95","author":"Chen","year":"2020","journal-title":"Neurology"},{"key":"10.7717\/peerj.15903\/ref-13","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1177\/0271678X19831583","article-title":"Cortical atrophy and transcallosal diaschisis following isolated subcortical stroke","volume":"40","author":"Cheng","year":"2020","journal-title":"Journal Of Cerebral Blood Flow And Metabolism"},{"key":"10.7717\/peerj.15903\/ref-14","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1161\/01.STR.0000092122.96722.72","article-title":"Interhemispheric asymmetries of motor cortex excitability in the postacute stroke stage: a paired-pulse transcranial magnetic stimulation study","volume":"34","author":"Cicinelli","year":"2003","journal-title":"Stroke"},{"key":"10.7717\/peerj.15903\/ref-15","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3233\/NRE-210307","article-title":"Effect and mechanism of mirror therapy on lower limb rehabilitation after ischemic stroke: a fMRI study","volume":"51","author":"Cui","year":"2022","journal-title":"Neurorehabilitation"},{"key":"10.7717\/peerj.15903\/ref-16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1310\/H65X-23HW-QL1G-KTNQ","article-title":"Brain reorganization after stroke","volume":"10","author":"Green","year":"2003","journal-title":"Topics in Stroke Rehabilitation"},{"key":"10.7717\/peerj.15903\/ref-17","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/ana.21228","article-title":"Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging","volume":"63","author":"Grefkes","year":"2008","journal-title":"Annals of Neurology"},{"key":"10.7717\/peerj.15903\/ref-18","doi-asserted-by":"publisher","first-page":"692304","DOI":"10.3389\/fnhum.2021.692304","article-title":"Brain functional changes in stroke following rehabilitation using brain-computer interface-assisted motor imagery with and without tDCS: a pilot study","volume":"15","author":"Hu","year":"2021","journal-title":"Frontiers in Human Neuroscience"},{"key":"10.7717\/peerj.15903\/ref-19","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/brain\/awh369","article-title":"Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke","volume":"128","author":"Hummel","year":"2005","journal-title":"Brain"},{"key":"10.7717\/peerj.15903\/ref-20","doi-asserted-by":"publisher","first-page":"378","DOI":"10.4103\/1735-5362.268198","article-title":"Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach","volume":"14","author":"Kuncahyo","year":"2019","journal-title":"Research in Pharmaceutical Sciences"},{"key":"10.7717\/peerj.15903\/ref-21","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1113\/jphysiol.2006.126011","article-title":"The effects of inhibitory and facilitatory intracortical circuits on interhemispheric inhibition in the human motor cortex","volume":"580","author":"Lee","year":"2007","journal-title":"Journal of Physiology-London"},{"key":"10.7717\/peerj.15903\/ref-22","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1212\/WNL.0b013e318202013a","article-title":"Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients","volume":"75","author":"Lindenberg","year":"2010","journal-title":"Neurology"},{"key":"10.7717\/peerj.15903\/ref-23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jad.2012.10.001","article-title":"Abnormal amplitude low-frequency oscillations in medication-naive, first-episode patients with major depressive disorder: a resting-state fMRI study","volume":"146","author":"Liu","year":"2013","journal-title":"Journal of Affective Disorders"},{"key":"10.7717\/peerj.15903\/ref-24","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1002\/hbm.23430","article-title":"Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic-clonic seizure","volume":"38","author":"Liu","year":"2017","journal-title":"Human Brain Mapping"},{"key":"10.7717\/peerj.15903\/ref-25","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1002\/hbm.23430","article-title":"Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic-clonic seizure","volume":"38","author":"Liu","year":"2017","journal-title":"Human Brain Mapping"},{"key":"10.7717\/peerj.15903\/ref-26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jns.2014.08.049","article-title":"Altered spontaneous activity in the default-mode network and cognitive decline in chronic subcortical stroke","volume":"347","author":"Liu","year":"2014","journal-title":"Journal of the Neurological Sciences"},{"key":"10.7717\/peerj.15903\/ref-27","doi-asserted-by":"publisher","first-page":"e897","DOI":"10.1016\/S2468-2667(21)00228-0","article-title":"Temporal trend and attributable risk factors of stroke burden in China, 1990\u20132019: an analysis for the Global Burden of Disease Study 2019","volume":"6","author":"Ma","year":"2021","journal-title":"Lancet Public Health"},{"key":"10.7717\/peerj.15903\/ref-28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.07.001","article-title":"Neural reuse of action perception circuits for language, concepts and communication","volume":"160","author":"Pulvermuller","year":"2018","journal-title":"Progress in Neurobiology"},{"key":"10.7717\/peerj.15903\/ref-29","doi-asserted-by":"publisher","first-page":"A118022913","DOI":"10.1161\/STROKEAHA.118.022913","article-title":"Long-term survival and function after stroke","author":"Sennfalt","year":"2018","journal-title":"Stroke"},{"key":"10.7717\/peerj.15903\/ref-30","doi-asserted-by":"publisher","first-page":"e675-e700","DOI":"10.1161\/STR.0000000000000388","article-title":"Clinical performance measures for stroke rehabilitation: performance measures from the American Heart Association\/American Stroke Association","volume":"52","author":"Stein","year":"2021","journal-title":"Stroke"},{"key":"10.7717\/peerj.15903\/ref-31","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1002\/hbm.23138","article-title":"Dorsal premotor activity and connectivity relate to action selection performance after stroke","volume":"37","author":"Stewart","year":"2016","journal-title":"Human Brain Mapping"},{"key":"10.7717\/peerj.15903\/ref-32","doi-asserted-by":"publisher","first-page":"036036","DOI":"10.1088\/1741-2552\/ac71ce","article-title":"More than just statics: altered complexity of dynamic amplitude of low-frequency fluctuations in the resting brain after stroke","volume":"19","author":"Tian","year":"2022","journal-title":"Journal of Neural Engineering"},{"key":"10.7717\/peerj.15903\/ref-33","doi-asserted-by":"publisher","first-page":"1906180997","DOI":"10.1177\/2042018819865723","article-title":"Evidence of altered brain network centrality in patients with diabetic nephropathy and retinopathy: an fMRI study using a voxel-wise degree centrality approach","volume":"10","author":"Wang","year":"2019","journal-title":"Therapeutic Advances in Endocrinology and Metabolism"},{"key":"10.7717\/peerj.15903\/ref-34","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3233\/RNN-211148","article-title":"Structural connectivity changes in the motor execution network after stroke rehabilitation","volume":"39","author":"Wanni","year":"2021","journal-title":"Restorative Neurology and Neuroscience"},{"key":"10.7717\/peerj.15903\/ref-35","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1017\/S0033291720003876","article-title":"Local dynamic spontaneous brain activity changes in first-episode, treatment-naive patients with major depressive disorder and their associated gene expression profiles","volume":"52","author":"Xue","year":"2022","journal-title":"Psychological Medicine"},{"key":"10.7717\/peerj.15903\/ref-36","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3389\/fneur.2018.00856","article-title":"Abnormal global brain functional connectivity in primary insomnia patients: a resting-state functional MRI study","volume":"9","author":"Yan","year":"2018","journal-title":"Frontiers in Neurology"},{"key":"10.7717\/peerj.15903\/ref-37","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1016\/j.scib.2017.09.015","article-title":"Concordance among indices of intrinsic brain function: insights from inter-individual variation and temporal dynamics","volume":"62","author":"Yan","year":"2017","journal-title":"Science Bulletin"},{"key":"10.7717\/peerj.15903\/ref-38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","article-title":"Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI","volume":"29","author":"Zang","year":"2007","journal-title":"Brain & Development"},{"key":"10.7717\/peerj.15903\/ref-39","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","article-title":"Regional homogeneity approach to fMRI data analysis","volume":"22","author":"Zang","year":"2004","journal-title":"Neuroimage"},{"key":"10.7717\/peerj.15903\/ref-40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1161\/STROKEAHA.121.034366","article-title":"Prevalence and prognostic significance of malnutrition risk in patients with acute ischemic stroke: results from the third china national stroke registry","volume":"53","author":"Zhang","year":"2022","journal-title":"Stroke"},{"key":"10.7717\/peerj.15903\/ref-41","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.brainres.2017.02.012","article-title":"Abnormal functional networks in resting-state of the sub-cortical chronic stroke patients with hemiplegia","volume":"1663","author":"Zhang","year":"2017","journal-title":"Brain Research"},{"key":"10.7717\/peerj.15903\/ref-42","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1093\/cercor\/bhr269","article-title":"Network centrality in the human functional connectome","volume":"22","author":"Zuo","year":"2012","journal-title":"Cerebral Cortex"}],"container-title":["PeerJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/peerj.com\/articles\/15903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/15903.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/15903.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/peerj.com\/articles\/15903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:44:34Z","timestamp":1693554274000},"score":1,"resource":{"primary":{"URL":"https:\/\/peerj.com\/articles\/15903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":42,"alternative-id":["10.7717\/peerj.15903"],"URL":"https:\/\/doi.org\/10.7717\/peerj.15903","archive":["CLOCKSS","LOCKSS","Portico"],"relation":{},"ISSN":["2167-8359"],"issn-type":[{"value":"2167-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]},"article-number":"e15903"}}