{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T06:54:48Z","timestamp":1725778488189},"reference-count":26,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>This study investigated the relationship between the systemic immune inflammation index (SII) and catheter-related infections and their effects on prognosis in pediatric patients.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>A total of 56 pediatric patients diagnosed with ventriculoperitoneal (V-P) shunt infection between January 2017 and October 2019 were included. V-P shunt infection diagnosis was made based on clinical findings. All cerebrospinal fluid (CSF) samples were subjected to direct microscopic examination and culture. Protein, glucose, and sodium levels in CSF, CSF leukocytes, and hematological and biochemical parameters were measured.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>Fifty-six patients with growth in CSF culture were included in this study. 55.4% of the cases were female and 44.6% male. V-P shunt was detected in 82.1% of the cases and external ventricular drainage (EVD) catheter-related infection in 17.9%. The CSF\/blood glucose ratio was significantly lower (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.046), and SII was significantly increased (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) in non-coagulase-negative staphylococci.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusions<\/jats:title>\n               <jats:p>Early and appropriate antibiotic therapy reduces morbidity and mortality in catheter-related infections. However, it is important to start empirical antibiotherapy until culture results are expected. Therefore, further research on the estimation of possible factors is needed.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.15905","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:12:57Z","timestamp":1694074377000},"page":"e15905","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between catheter related cerebrospinal fluid infections and systemic immune-inflammation index"],"prefix":"10.7717","volume":"11","author":[{"given":"Sebnem","family":"Nergiz","sequence":"first","affiliation":[{"name":"Department of Dietetics and Nutrition, Dicle University, Ataturk Faculty of Health Sciences, Diyarbakir,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Aydin Ozturk","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Health Sciences University of Turkey, Diyarbak\u0131r Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"issue":"6","key":"10.7717\/peerj.15905\/ref-1","first-page":"527","article-title":"Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index in patients with COVID-19-associated pneumonia","volume":"156","author":"Carpio-Orantes","year":"2020","journal-title":"Gaceta Medica de Mexico"},{"key":"10.7717\/peerj.15905\/ref-2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4103\/jpn.JPN_216_20","article-title":"Bacteriological profile and antimicrobial susceptibility pattern of cerebrospinal fluid shunt infections in infants and children","volume":"16","author":"Chaurasia","year":"2021","journal-title":"Journal of Pediatric Neurosciences"},{"key":"10.7717\/peerj.15905\/ref-3","doi-asserted-by":"publisher","first-page":"745175","DOI":"10.3389\/fneur.2021.745175","article-title":"Increased systemic immune-inflammation index is associated with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients","volume":"12","author":"Chen","year":"2021","journal-title":"Frontiers in Neurology"},{"issue":"34","key":"10.7717\/peerj.15905\/ref-4","doi-asserted-by":"publisher","first-page":"6261","DOI":"10.3748\/wjg.v23.i34.6261","article-title":"Systemic immune-inflammation index for predicting prognosis of colorectal cancer","volume":"23","author":"Chen","year":"2017","journal-title":"World Journal of Gastroenterology"},{"key":"10.7717\/peerj.15905\/ref-5","volume-title":"Performance standards for antimicrobial susceptibility testing. 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