{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:17:40Z","timestamp":1775186260599,"version":"3.50.1"},"reference-count":23,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>To assess changes of dorsal root ganglia (DRG) and spinal nerves in patients with postherpetic neuralgia (PHN), and investigate the correlation between DRG morphology and clinical symptoms in PHN patients using magnetic resonance neurography (MRN).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In this case-control study, forty-nine lesioned DRG in 30 patients and 49 normal DRG in 30 well-matched (age, sex, height, weight) healthy controls were assessed. Clinical symptoms of patients (pain, allodynia, itching, and numbness) were assessed. MRN features (DRG volume (V<jats:sub>DRG<\/jats:sub>), the largest diameter (D<jats:sub>max<\/jats:sub>) of spinal nerves, signal intensity of DRG and spinal nerves (M-value)) were measured in all participants. Multilinear regression analysis was used to evaluate the relationship between the DRG morphology and clinical symptoms in patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The volume and relative M-value of lesioned DRG in patients were significantly higher than those on the same side of healthy controls (<jats:italic>p<\/jats:italic> = 0.013, <jats:italic>p<\/jats:italic> &lt; 0.001, respectively). The mean D<jats:sub>max<\/jats:sub> and relative M-value of spinal nerves on the lesioned side were significantly higher than those on the contralateral and same side of healthy controls (<jats:italic>p<\/jats:italic> &lt; 0.0001, <jats:italic>p<\/jats:italic> = 0.0001, <jats:italic>p<\/jats:italic> = 0.0011, <jats:italic>p<\/jats:italic> = 0.0053, respectively). No difference was found between the mean V<jats:sub>DRG<\/jats:sub> of the lesioned and contralateral sides. Multiple linear regression analysis revealed that disease duration was independent risk factor for the maximum rate of V<jats:sub>DRG<\/jats:sub> differences (<jats:italic>p<\/jats:italic> = 0.013).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>DRG and spinal nerves on the lesioned side are swollen during PHN. Disease duration is an independent risk factor for morphological differences in the lesioned DRG of PHN patients. This study provides important guidance for individualized treatments of PHN.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.15998","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T07:28:54Z","timestamp":1693466934000},"page":"e15998","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the correlation of dorsal root ganglia and spinal nerves with clinical symptoms in patients with postherpetic neuralgia using magnetic resonance neurography"],"prefix":"10.7717","volume":"11","author":[{"given":"Xueqin","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyou","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"10.7717\/peerj.15998\/ref-1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.4103\/JCAS.JCAS_45_20","article-title":"Post-herpetic neuralgia: a systematic review of current interventional pain management strategies","volume":"13","author":"Aggarwal","year":"2020","journal-title":"Journal of Cutaneous and Aesthetic Surgery"},{"key":"10.7717\/peerj.15998\/ref-2","first-page":"E303","article-title":"Abnormal local brain 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