{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:58:59Z","timestamp":1789473539630,"version":"build-2803163510"},"reference-count":29,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Tetanus remains a significant public health issue in China, with the approach of anti-tetanus prophylaxis in the emergency department resulting in both overuse, particularly of human tetanus immune globulin (TIG), and underuse with the tetanus vaccine. This is largely due to the absence of updated guidelines on tetanus prophylaxis before 2018. Our study aimed to evaluate the effects of the 2018 Chinese tetanus guidelines on the knowledge and practices of emergency physicians about tetanus prevention in trauma patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>From November 2019 to April 2020, we conducted a web-based survey involving 499 emergency physicians. The survey included a questionnaire covering knowledge, attitudes, and practices related to tetanus. We assessed the influence of the 2018 tetanus guidelines on the knowledge and practices of emergency physicians related to tetanus prevention for patients with trauma using multiple regression analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The survey results showed that only 45.3% of the participants had received formal training on tetanus immunization, despite 53.3% reporting the availability of tetanus vaccines at their institutions. Physicians typically prescribed tetanus antitoxin or human TIG instead of tetanus toxoid (TT) to treat injuries, regardless of the patient\u2019s TT vaccination history. Among the respondents, those who were aware of the 2018 tetanus guidelines had higher mean scores on the general knowledge, risk knowledge, and treatment knowledge scales, with increases of 6%, 13%, and 9%, respectively, compared to those who were unaware of the guidelines. Awareness of the 2018 tetanus guidelines was associated with a high level of knowledge, as indicated by the general knowledge score, recommendation knowledge score, and total knowledge score, after adjusting for the effects of all variables on the knowledge, attitudes, and practices of the participants. A high level of education was also associated with a high level of knowledge indicated by the recommendation knowledge score and total knowledge score.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our study highlights a substantial gap in the attitudes, knowledge, and practices of emergency physicians in China regarding tetanus immunization. The results suggest an urgent need to promote the Chinese Expert Consensus Guidelines on tetanus to improve emergency physicians\u2019 knowledge and competence in tetanus prophylaxis. The findings underscore the importance of enhancing physicians\u2019 awareness of the latest guidelines to ensure appropriate and effective treatment for patients with tetanus-prone injuries.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.16032","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:21:42Z","timestamp":1693812102000},"page":"e16032","source":"Crossref","is-referenced-by-count":8,"title":["Assessing the impact of the 2018 tetanus guidelines on knowledge and practices of emergency physicians in trauma patients: a national survey study"],"prefix":"10.7717","volume":"11","author":[{"given":"Junling","family":"Gao","sequence":"first","affiliation":[{"name":"Buddhist Practices and Counselling Science Lab, Centre of Buddhist Studies, The University of Hong Kong, Hong Kong SAR, China"},{"name":"Department of Intensive Care Unit, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaxia","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Cao","sequence":"additional","affiliation":[{"name":"Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingde","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Hong Kong, Hong Kong SAR, 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Science and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3404-3888","authenticated-orcid":true,"given":"Thuan-Quoc","family":"Thach","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"10.7717\/peerj.16032\/ref-1","article-title":"Tetanus immune globulin (Monograph)","author":"ASHP","year":"2022"},{"issue":"35","key":"10.7717\/peerj.16032\/ref-2","doi-asserted-by":"publisher","first-page":"4478","DOI":"10.1016\/j.vaccine.2014.06.046","article-title":"Personal attitudes and 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