{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:56:53Z","timestamp":1754488613908},"reference-count":35,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research foundation","doi-asserted-by":"crossref","award":["RU 2371\/1"],"award-info":[{"award-number":["RU 2371\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Hypoxia-induced neuroinflammation after cardiac arrest has been shown to be mitigated by different ventilation methods. In this prospective randomized animal trial, 35 landrace pigs were randomly divided into four groups: intermittent positive pressure ventilation (IPPV), synchronized ventilation 20 mbar (SV 20 mbar), chest compression synchronized ventilation 40 mbar (CCSV 40 mbar) and a control group (Sham). After inducing ventricular fibrillation, basic life support (BLS) and advanced life support (ALS) were performed, followed by post-resuscitation monitoring. After 6 hours, the animals were euthanized, and direct postmortem brain tissue samples were taken from the hippocampus (HC) and cortex (Cor) for molecular biological investigation of cytokine mRNA levels of Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF\u03b1). The data analysis showed that CCSV 40 mbar displayed low TNF\u03b1 mRNA-levels, especially in the HC, while the highest TNF\u03b1 mRNA-levels were detected in SV 20 mbar. The results indicate that chest compression synchronized ventilation may have a potential positive impact on the cytokine expression levels post-resuscitation. Further studies are needed to derive potential therapeutic algorithms from these findings.<\/jats:p>","DOI":"10.7717\/peerj.16062","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:16:50Z","timestamp":1695975410000},"page":"e16062","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of cerebral Interleukin-6 and tumor necrosis factor alpha patterns following different ventilation strategies during cardiac arrest in pigs"],"prefix":"10.7717","volume":"11","author":[{"given":"Miriam","family":"Renz","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Johannes-Gutenberg Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Johannes-Gutenberg Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Herbst","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Epidemiology and Information Technology, University Medical Center of the Johannes Gutenberg Universit\u00e4t, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Johannes-Gutenberg Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Mohnke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Johannes-Gutenberg Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Ziebart","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Johannes-Gutenberg Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ruemmler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Johannes-Gutenberg Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4443","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"issue":"1","key":"10.7717\/peerj.16062\/ref-1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s12975-018-0617-z","article-title":"Release of IL-6 after stroke contributes to impaired cerebral autoregulation and hippocampal neuronal necrosis through NMDA receptor activation and upregulation of ET-1 and JNK","volume":"10","author":"Armstead","year":"2019","journal-title":"Translational Stroke Research"},{"issue":"4","key":"10.7717\/peerj.16062\/ref-2","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.resuscitation.2013.11.022","article-title":"Ischaemic brain damage after cardiac arrest and induced hypothermia\u2013a systematic description of selective eosinophilic neuronal death. 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