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The lipid accumulation and endoplasmic reticulum stress (ERS)-related proteins in hepatocytes of mice were detected by hematoxylin-eosin (HE) staining, oil red O staining and Western blotting.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The expressions of GRP78, GRP94, p-PERK and p-IRE1\u03b1 were significantly inhibited in test group compared with those in model group. The protein expressions of p-NF-\u03baB, p-JNK, IL-1\u03b2, IL-18 and NOX4 in test group were also significantly lower than those in model group. <jats:italic>In vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> experiments revealed that the body weight and lipid droplet content, and the expressions of ERS-related proteins (including BIP and XBP-1) in liver tissues all significantly declined in model group compared with those in 3021 MRP group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In conclusion, 3021 MRP can greatly reduce lipid accumulation by inhibiting ERS, oxidative stress and inflammatory response in NAFLD.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.16154","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:50:18Z","timestamp":1697442618000},"page":"e16154","source":"Crossref","is-referenced-by-count":3,"title":["Effects of 3021 meal replacement powder protect NAFLD via suppressing 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