{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:46:31Z","timestamp":1765547191476},"reference-count":61,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Education","award":["TED\/MEC n. 9249"],"award-info":[{"award-number":["TED\/MEC n. 9249"]}]},{"name":"The National Council for Scientific and Technological Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>This study evaluated clinical features of individuals with long COVID (5\u20138 months after diagnosis) who reported sleep and memory problems (62 cases) compared to those without (52 controls). Both groups had a similar mean age (41 <jats:italic>vs.<\/jats:italic> 39 years). Around 86% of the participants were non-hospitalized at the time of infection, and none of them were vaccinated at that point. Subsequently, both cases and controls received the vaccine; however, the vaccination rates differed significantly between the groups (30.7% <jats:italic>vs.<\/jats:italic> 51.0%). Cases and controls had similar rates of symptoms at acute COVID phase. However, cases were more likely to experience coryza, dyspnea, headache, and nausea\/vomiting during long COVID. Regarding new-onset symptoms in long COVID, 12.9% of cases had dyspnea, and 14.5% experienced nausea\/vomiting, whereas in the control group there were only 1.9% and 0.0%, respectively. Cases also had a significantly higher prevalence of persistent headache (22.6% <jats:italic>vs.<\/jats:italic> 7.7%), and dyspnea (12.9% <jats:italic>vs.<\/jats:italic> 0.0). In addition, cases also showed an increased rate of mental health complaints: disability in daily activities (45.2% <jats:italic>vs.<\/jats:italic> 9.6%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); concentration\/sustained attention difficulties (74.2% <jats:italic>vs.<\/jats:italic> 9.6%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); anxiety\u2013Generalized Anxiety Disorder 2-item scale (GAD-2) \u2265 3 (66.1% <jats:italic>vs.<\/jats:italic> 34.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0013); and \u201cpost-COVID sadness\u201d (82.3% <jats:italic>vs.<\/jats:italic> 40.4%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). We observed a significant correlation between sadness and anxiety in cases, which was not observed in controls (P=0.0212; Spearman correlation test). Furthermore, the frequency of concomitant sadness and anxiety was markedly higher in cases compared to controls (59.7% <jats:italic>vs.<\/jats:italic> 19.2%) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001; Mann-Whitney test). These findings highlight a noteworthy association between sadness and anxiety specifically in cases. In conclusion, our data identified concurrent psychological phenotypes in individuals experiencing sleep and memory disturbances during long COVID. This strengthens the existing evidence that SARS-CoV-2 causes widespread brain pathology with interconnected phenotypic clusters. This finding highlights the need for comprehensive medical attention to address these complex issues, as well as major investments in testing strategies capable of preventing the development of long COVID sequelae, such as vaccination.<\/jats:p>","DOI":"10.7717\/peerj.16669","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T03:21:10Z","timestamp":1706584870000},"page":"e16669","source":"Crossref","is-referenced-by-count":10,"title":["Sleep and memory complaints in long COVID: an insight into clustered psychological phenotypes"],"prefix":"10.7717","volume":"12","author":[{"given":"Ricardo","family":"Titze-de-Almeida","sequence":"first","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"},{"name":"University of Bras\u00edlia\/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratory, Bras\u00edlia, DF, 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Silva","family":"Vianna","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Machado","family":"Costa","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elo\u00edsa","family":"Pereira dos Santos","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise Marie Coelho","family":"Gu\u00e9rard","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Augusto de Miranda","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Cristina","family":"Rodrigues dos Santos","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Daniele da Silva","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Ginani Ferreira","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"},{"name":"University of Bras\u00edlia\/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratory, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simoneide","family":"Souza Titze-de-Almeida","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"},{"name":"University of Bras\u00edlia\/FAV, Central Institute of Sciences, Technology for Gene Therapy Laboratory, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Renato de Paula","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"},{"name":"S\u00edrio-Liban\u00eas Hospital, Bras\u00edlia, Brazil., Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Eri Shimizu","sequence":"additional","affiliation":[{"name":"Department of Collective Health, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrezza Paula Brito","family":"Silva","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimundo Nonato","family":"Delgado-Rodrigues","sequence":"additional","affiliation":[{"name":"Central Institute of Sciences, Research Center for Major Themes, University of Bras\u00edlia, Bras\u00edlia, DF, 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