{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:42:50Z","timestamp":1791384170603,"version":"4.3.3"},"reference-count":155,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32260089"],"award-info":[{"award-number":["32260089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Subject of Innovation and Entrepreneurship Education of Guizhou Ordinary Undergraduate Colleges","award":["2022SCJZW10"],"award-info":[{"award-number":["2022SCJZW10"]}]},{"name":"Future Outstanding Teachers Training Program of Zunyi Medical University","award":["ZMUWLJXMS-2021XDL"],"award-info":[{"award-number":["ZMUWLJXMS-2021XDL"]}]},{"name":"Postgraduate Teaching Reform Project of Zunyi Medical University","award":["ZYK105"],"award-info":[{"award-number":["ZYK105"]}]},{"name":"Joint Biding Project of Zunyi Science & Technology Department and Zunyi Medical University","award":["ZSKHHZ[2020]91"],"award-info":[{"award-number":["ZSKHHZ[2020]91"]}]},{"name":"Science and Technology Department Foundation of Guizhou Province of China","award":["QKPTRC [2019]-027"],"award-info":[{"award-number":["QKPTRC [2019]-027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Liver disease is a common and serious threat to human health. The progression of liver diseases is influenced by many physiologic processes, including oxidative stress, inflammation, bile acid metabolism, and autophagy. Various factors lead to the dysfunction of these processes and basing on the different pathogeny, pathology, clinical manifestation, and pathogenesis, liver diseases are grouped into different categories. Specifically, Sirtuin1 (SIRT1), a member of the sirtuin protein family, has been extensively studied in the context of liver injury in recent years and are confirmed the significant role in liver disease. SIRT1 has been found to play a critical role in regulating key processes in liver injury. Further, SIRT1 seems to cause divers outcomes in different types of liver diseases. Recent studies have showed some therapeutic strategies involving modulating SIRT1, which may bring a novel therapeutic target. To elucidate the mechanisms underlying the role of sirtuin1 in liver injury and its potentiality as a therapeutic target, this review outlines the key signaling pathways associated with sirtuin1 and liver injury, and discusses recent advances in therapeutic strategies targeting sirtuin1 in liver diseases.<\/jats:p>","DOI":"10.7717\/peerj.17094","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T08:42:25Z","timestamp":1711701745000},"page":"e17094","source":"Crossref","is-referenced-by-count":15,"title":["The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target"],"prefix":"10.7717","volume":"12","author":[{"given":"Mufei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Instrumental Analysis, Zunyi Medical University, Zunyi, Guizhou, China"},{"name":"Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 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