{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:35:36Z","timestamp":1781710536590,"version":"3.54.5"},"reference-count":93,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Student Scientific Circles Create Innovations","award":["SKN\/SP\/498248\/2021"],"award-info":[{"award-number":["SKN\/SP\/498248\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Physical activity is an important factor in modelling the remodelling and metabolism of bone tissue. The aim of the study was to evaluate the changes in indices demonstrating bone turnover in men under the influence of maximum-intensity exercise.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>The study involved 33 men aged 20\u201325, divided into two groups: experimental (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a018). People training medium- and long-distance running were assigned to the experimental group, and non-training individuals to the control. Selected somatic, physiological and biochemical indices were measured. The level of aerobic fitness was determined using a progressively increasing graded test (treadmill test for subjective fatigue). Blood samples for determinations were taken before the test and 60 minutes after its completion. The concentration of selected bone turnover markers was assessed: bone fraction of alkaline phosphatase (b-ALP), osteoclacin (OC), N-terminal cross-linked telopeptide of the alpha chain of type I collagen (NTx1), N-terminal propeptide of type I progolagen (PINP), osteoprotegerin (OPG). In addition, the concentration of 25(OH)D3 prior to the stress test was determined. Additionally, pre and post exercise, the concentration of lactates in the capillary blood was determined.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>When comparing the two groups, significant statistical differences were found for the mean level of: 25(OH)D3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.025), b-ALP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), OC (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) and PINP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.029) prior to the test. On the other hand, within individual groups, between the values pre and post the stress test, there were statistically significant differences for the average level of: b-ALP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), NTx1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), OPG (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and PINP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>A single-session maximum physical effort can become an effective tool to initiate positive changes in bone turnover markers.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.17258","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:37:56Z","timestamp":1715931476000},"page":"e17258","source":"Crossref","is-referenced-by-count":3,"title":["Changes in the concentration of bone turnover markers in men after maximum intensity exercise"],"prefix":"10.7717","volume":"12","author":[{"given":"Ma\u0142gorzata","family":"Bagi\u0144ska","sequence":"first","affiliation":[{"name":"Faculty of Physical Education and Sport, University of Physical Education in Krak\u00f3w, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz Marcin","family":"Tota","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, University of Physical Education in Krak\u00f3w, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Morawska-Tota","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine and Human Nutrition, University of Physical Education in Krak\u00f3w,  Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Kusmierczyk","sequence":"additional","affiliation":[{"name":"Department of Physiology and 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