{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:18:12Z","timestamp":1789690692110,"version":"4.0.1"},"reference-count":119,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bobby Baker Memorial Scholarship for Excellence in Scientific and Genomics Research"},{"name":"State of Texas line item"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Transmissible spongiform encephalopathies (TSEs) are a fatal neurogenerative disease that include Creutzfeldt\u2013Jakob disease in humans, scrapie in sheep and goats, bovine spongiform encephalopathy (BSE), and several others as well as the recently described camel prion disease (CPD). CPD originally was documented in 3.1% of camels examined during an antemortem slaughterhouse inspection in the Ouargla region of Algeria. Of three individuals confirmed for CPD, two were sequenced for the exon 3 of the prion protein gene (PRNP) and were identical to sequences previously reported for\n                    <jats:italic>Camelus dromedarius<\/jats:italic>\n                    . Given that other TSEs, such as BSE, are known to be capable of cross\u2013species transmission and that there is household consumption of meat and milk from\n                    <jats:italic>Camelus<\/jats:italic>\n                    , regulations to ensure camel and human health should be a One Health priority in exporting countries. Although the interspecies transmissibility of CPD currently is unknown, genotypic characterization of\n                    <jats:italic>Camelus PRNP<\/jats:italic>\n                    may be used for predictability of predisposition and potential susceptibility to CPD. Herein, eight breeds of dromedary camels from a previous genetic (mitochondrial DNA and microsatellites) and morphological study were genotyped for\n                    <jats:italic>PRNP<\/jats:italic>\n                    and compared to genotypes from CPD\u2013positive Algerian camels. Sequence data from\n                    <jats:italic>PRNP<\/jats:italic>\n                    indicated that Ethiopian camels possessed 100% sequence identity to CPD\u2013positive camels from Algeria. In addition, the camel\n                    <jats:italic>PRNP<\/jats:italic>\n                    genotype is unique compared to other members of the Orders Cetartiodactyla and Perissodactyla and provides an in\u2013depth phylogenetic analysis of families within Cetartiodactyla and Perissodactyla that was used to infer the evolutionary history of the\n                    <jats:italic>PRNP<\/jats:italic>\n                    gene.\n                  <\/jats:p>","DOI":"10.7717\/peerj.17552","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T03:22:00Z","timestamp":1719458520000},"page":"e17552","source":"Crossref","is-referenced-by-count":6,"title":["Genetic characterization of the prion protein gene in camels (\n                    <i>Camelus<\/i>\n                    ) with comments on the evolutionary history of prion disease in Cetartiodactyla"],"prefix":"10.7717","volume":"12","author":[{"given":"Emily A.","family":"Wright","sequence":"first","affiliation":[{"name":"Natural Science Research Laboratory, Museum of Texas Tech University, Lubbock, TX,  United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison B.","family":"Reddock","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Texas Tech University, Lubbock, TX, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma K.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Texas Tech University, Lubbock, TX, United States of America"},{"name":"Climate Center, Texas Tech University, Lubbock, TX, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoseph W.","family":"Legesse","sequence":"additional","affiliation":[{"name":"School of Animal and Range Sciences, Haramaya University, Dire Dawa, Ethiopia"},{"name":"Institute of Pastoral and Agropastoral Development Studies, Jigjiga University, Jigjiga, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Natural Resources Management, Texas Tech University, Lubbock, TX,  United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Natural Science Research Laboratory, Museum of Texas Tech University, Lubbock, TX,  United States of America"},{"name":"Department of Biological Sciences, Texas Tech University, Lubbock, TX, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"10.7717\/peerj.17552\/ref-1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.54172\/mjsc.v37i1.622","article-title":"Scrapie in Eastern Libya: case report in 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