{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:10:43Z","timestamp":1792203043837,"version":"4.4.0"},"reference-count":42,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cisplatin (CIS) is a broad-spectrum anticancer drug, with cytotoxic effects on either malignant or normal cells. We aimed to evaluate the hepatotoxicity in rats caused by CIS and its amelioration by the co-administration of either curcumin or resveratrol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty adult male rats divided into four equal groups: (control group): rats were given a saline solution (0.9%) once intraperitoneally, daily for the next 28 days; (cisplatin group): rats were given a daily oral dose of saline solution (0.9%) for 28 days after receiving a single dose of cisplatin (3.3 mg\/kg) intraperitoneally for three successive days; (CIS plus curcumin\/resveratrol groups): rats received the same previous dose of cisplatin (3.3 mg\/kg) daily for three successive days followed by oral administration of either curcumin\/resveratrol solution at a dose of (20 mg\/kg) or (10 mg\/kg) consequently daily for 28 days. Different laboratory tests (ALT, AST, ALP, bilirubin, oxidative stress markers) and light microscopic investigations were done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Administration of CIS resulted in hepatotoxicity in the form of increased liver enzymes, oxidative stress markers; degenerative and apoptotic changes, the co-administration of CIS with either curcumin or resveratrol improved hepatotoxicity through improved microscopic structural changes, reduction in liver enzymes activity, decreased oxidative stress markers, improved degenerative, and apoptotic changes in liver tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Co-administration of either curcumin or resveratrol with cisplatin treatment could ameliorate hepatotoxicity caused by cisplatin in rats\n                      <jats:italic>via<\/jats:italic>\n                      anti-inflammatory and oxidative stress-apoptotic pathways.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.17687","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T03:45:52Z","timestamp":1721619952000},"page":"e17687","source":"Crossref","is-referenced-by-count":10,"title":["Co-administration of either curcumin or resveratrol with cisplatin treatment decreases hepatotoxicity in rats\n                    <i>via<\/i>\n                    anti-inflammatory and oxidative stress-apoptotic pathways"],"prefix":"10.7717","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-5494","authenticated-orcid":true,"given":"Osama I.","family":"Ramadan","sequence":"first","affiliation":[{"name":"Department of Dental Basic Sciences, Faculty of Dentistry, Applied Science Private University, Amman, Jordan"},{"name":"Histology Department, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lashin","family":"S. Ali","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Faculty of Dentistry, Al-Ahliyya Amman University, Amman, Jordan"},{"name":"Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"M. Abd-Allah","sequence":"additional","affiliation":[{"name":"Histology Department, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafik","family":"E. A. Ereba","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humeda","family":"S. Humeda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Alzaiem AlAzhari University, Khartoum North, Sudan"},{"name":"Physiology Department, General Medicine Practice Program, Batterjee Medical College, Aseer, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"A. Damanhory","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"},{"name":"Department of Biochemistry, General Medicine Practice Program, Batterjee Medical College, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"E. Moustafa","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"M. 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