{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:27:33Z","timestamp":1785526053093,"version":"3.56.0"},"reference-count":123,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Natural Science Foundation of Chongqing, China","award":["No. cstc2020jcyj-msxmX0538"],"award-info":[{"award-number":["No. cstc2020jcyj-msxmX0538"]}]},{"name":"The Natural Science Foundation of Chongqing, China","award":["No. cstb2022nscq-msxc324"],"award-info":[{"award-number":["No. cstb2022nscq-msxc324"]}]},{"DOI":"10.13039\/501100002858","name":"The China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2023M740439"],"award-info":[{"award-number":["2023M740439"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cancer is a serious public health problem worldwide. Traditional treatments, such as surgery, radiotherapy, chemotherapy, and immunotherapy, do not always yield satisfactory results; therefore, an efficient treatment for tumours is urgently needed. As a convenient and minimally invasive modality, focused ultrasound (FUS) has been used not only as a diagnostic tool but also as a therapeutic tool in an increasing number of studies. FUS can help treat malignant tumours by inducing apoptosis. This review describes the three apoptotic pathways, apoptotic cell clearance, and how FUS affects these three apoptotic pathways. This review also discusses the role of thermal and cavitation effects on apoptosis, including caspase activity, mitochondrial dysfunction, and Ca<jats:sup>2+<\/jats:sup> elease. Finally, this article reviews various aspects of FUS combination therapy, including sensitization by radiotherapy and chemotherapy, gene expression upregulation, and the introduction of therapeutic gases, to provide new ideas for clinical tumour therapy.<\/jats:p>","DOI":"10.7717\/peerj.17886","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T11:32:04Z","timestamp":1724326324000},"page":"e17886","source":"Crossref","is-referenced-by-count":2,"title":["Focused ultrasound-induced cell apoptosis for the treatment of tumours"],"prefix":"10.7717","volume":"12","author":[{"given":"Na","family":"Wang","sequence":"first","affiliation":[{"name":"Chongqing University, School of Medicine, Chongqing, China"},{"name":"Chongqing University Cancer Hospital, Ultrasound Department, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Chongqing University Cancer Hospital, Ultrasound Department, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhi","family":"Xu","sequence":"additional","affiliation":[{"name":"Chongqing University Cancer Hospital, Ultrasound Department, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing University Cancer Hospital, Ultrasound Department, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University Cancer Hospital, Ultrasound Department, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"issue":"9","key":"10.7717\/peerj.17886\/ref-1","doi-asserted-by":"publisher","first-page":"a036384","DOI":"10.1101\/cshperspect.a036384","article-title":"Death receptors and their ligands in inflammatory disease and cancer","volume":"12","author":"Annibaldi","year":"2020","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"10.7717\/peerj.17886\/ref-2","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1080\/15548627.2022.2100105","article-title":"Lack of COL6\/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis","volume":"19","author":"Abbonante","year":"2023","journal-title":"Autophagy"},{"key":"10.7717\/peerj.17886\/ref-3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.molcel.2023.11.040","article-title":"The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death","volume":"84","author":"Ai","year":"2024","journal-title":"Molecular Cell"},{"key":"10.7717\/peerj.17886\/ref-4","doi-asserted-by":"publisher","first-page":"112333","DOI":"10.1016\/j.jphotobiol.2021.112333","article-title":"Titaniumdioxide mediated sonophotodynamic therapy against prostate cancer","volume":"225","author":"Aksel","year":"2021","journal-title":"Journal of Photochemistry and Photobiology. 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