{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:57:25Z","timestamp":1780563445103,"version":"3.54.1"},"reference-count":31,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Pregabalin abuse is a rapidly growing health problem worldwide, and little is known about the effects of prolonged high-dose use in patients with pregabalin use disorder.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>In this study, the effects of pregabalin abuse on retinal layers were investigated in patients with pregabalin use disorder (PGUD).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>This study included 35 controls and 34 patients with PGUD, according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria. Optic coherence tomography (OCT) measurements including the retinal nerve fiber layer (RNFL), ganglion cell layer-inner plexiform layer (GCL-IPL) and ganglion cell complex (GCC) were performed. RNFL thickness was evaluated in four quadrants (inferior, superior, nasal, temporal). GCL-IPL and GCC thickness were evaluated in six sectors (superior, superonasal, inferonasal, inferior, inferotemporal, superotemporal).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>GCC inferonasal (<jats:italic>p<\/jats:italic> = 0.040, r = 0.354), GCC inferior (<jats:italic>p<\/jats:italic> = 0.018, r = 0.402) GCL-IPL inferior (<jats:italic>p<\/jats:italic> = 0.031, r = 0.370) and GCL-IPL inferotemporal (<jats:italic>p<\/jats:italic> = 0.029, r = 0.376) thickness were positively correlated with the duration of pregabalin use. There was no significant sector or quadrant-wise difference between groups (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our findings emphasized the drug\u2019s potential neuroprotective effect. It should be taken into consideration that neurodegenerative changes due to substance use disorder occur with long-term. Longitudinal prospective studies investigating dose-duration relationship are needed.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.18395","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T08:36:22Z","timestamp":1731314182000},"page":"e18395","source":"Crossref","is-referenced-by-count":1,"title":["Examination of optical coherence tomography findings in patients with pregabalin use disorder"],"prefix":"10.7717","volume":"12","author":[{"given":"Osman Hasan Tahsin","family":"K\u0131l\u0131\u00e7","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, \u0130zmir Democracy University, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra Nur","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Health Sciences, \u0130zmir Democracy University, \u0130zmir, 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