{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:58:12Z","timestamp":1783403892173,"version":"3.54.6"},"reference-count":23,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint funds for the innovation of science and technology, Fujian province","award":["No. 2023Y9231"],"award-info":[{"award-number":["No. 2023Y9231"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>Prostate biopsies are primarily conducted using either the transrectal or transperineal approach, with the ultrasound probe positioned in the rectum to obtain a clear view of the prostate. Reports on the utilization of transperineal prostate biopsies with the ultrasound probe placed on the perineal skin are limited.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>A retrospective investigation was conducted on 119 patients who underwent transperineal ultrasound guided transperineal prostate biopsy (TP-TPPB). Additionally, 85 patients who underwent transrectal ultrasound guided transperineal prostate biopsy (TR-TPPB) were included as controls. The prostate cancer detection rates (PCDRs) and postoperative complication rates were compared between the two groups, and their application values were also evaluated.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>The overall PCDRs were 35.3% (42\/119) in the TP-TPPB and 32.9% (28\/85) in the TR-TPPB group (<jats:italic>\u03c7<\/jats:italic>2\u00a0=\u00a00.122, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.727). When categorized by PSA level, there was no significant difference between the two groups in PCDRs in any category (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). However, the single-needle PCDRs in some regions (L4, L5, R2, and apex) showed significant differences (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). There was no difference in postoperative complication rates between the groups.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>The PCDRs and the postoperative complication rates of TP-TPPB and TR-TPPB are similar. However, TP-TPPB requires simpler equipment and does not require intestinal preparation, which is especially useful for patients with rectal contraindications, such as those with severe hemorrhoids and rectal\/anal diseases.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.18424","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T08:34:37Z","timestamp":1731314077000},"page":"e18424","source":"Crossref","is-referenced-by-count":1,"title":["Transperineal prostate biopsy guided by which ultrasound transducer: transrectal or transperineal: a retrospective study"],"prefix":"10.7717","volume":"12","author":[{"given":"Yang","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Ultrasonography, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"10.7717\/peerj.18424\/ref-1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ucl.2020.09.010","article-title":"Recent advances and current role of transperineal prostate biopsy","volume":"48","author":"Bhanji","year":"2021","journal-title":"Urologic Clinics of North America"},{"key":"10.7717\/peerj.18424\/ref-2","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1007\/s00345-020-03112-3","article-title":"Infectious complications of prostate biopsy: winning battles but not war","volume":"38","author":"Derin","year":"2020","journal-title":"World The Journal of Urology"},{"issue":"5","key":"10.7717\/peerj.18424\/ref-3","doi-asserted-by":"publisher","first-page":"191.e9-191.e14","DOI":"10.1016\/j.urolonc.2022.01.004","article-title":"Comparisons of efficacy and complications between transrectal and transperineal prostate biopsy with or without antibiotic prophylaxis","volume":"40","author":"He","year":"2022","journal-title":"Urologic Oncology"},{"key":"10.7717\/peerj.18424\/ref-4","doi-asserted-by":"publisher","first-page":"612","DOI":"10.4103\/aja.aja_16_19","article-title":"Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study","volume":"21","author":"Jiang","year":"2019","journal-title":"Asian Journal of Andrology"},{"key":"10.7717\/peerj.18424\/ref-5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S0022-5347(17)38746-3","article-title":"Identification of residual cancer in the prostate following radiation therapy: role of transrectal ultrasound guided biopsy and prostate specific antigen","volume":"142","author":"Kabalin","year":"1989","journal-title":"The Journal of Urology"},{"key":"10.7717\/peerj.18424\/ref-6","doi-asserted-by":"publisher","first-page":"872411","DOI":"10.3389\/fendo.2022.872411","article-title":"Zinc-loaded black phosphorus multifunctional nanodelivery system combined with photothermal therapy have the potential to treat prostate cancer patients infected with COVID-19","volume":"13","author":"Li","year":"2022","journal-title":"Frontiers in Endocrinology"},{"issue":"4","key":"10.7717\/peerj.18424\/ref-7","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.juro.2010.11.088","article-title":"Prevalence and significance of fluoroquinolone resistant Escherichia coli in patients undergoing transrectal ultrasound guided prostate needle biopsy","volume":"185","author":"Liss","year":"2011","journal-title":"The Journal of Urology"},{"key":"10.7717\/peerj.18424\/ref-8","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1001\/jama.2017.7248","article-title":"The diagnosis and treatment of prostate cancer: a review","volume":"317","author":"Litwin","year":"2017","journal-title":"JAMA"},{"issue":"2","key":"10.7717\/peerj.18424\/ref-9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/pros.23934","article-title":"Prostate cancer research: the next generation; 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