{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:46:51Z","timestamp":1768096011050,"version":"3.49.0"},"reference-count":29,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>The dropout rate of contact lens users has not decreased significantly over the years. Despite continuous improvements in contact lens (CL) designs, materials and surface treatments, the number of CL users who drop out remains similar to the number of new CL users. The aim of this study is to analyse the improvement in contact lens-associated dry eye disease (CLADE), quantified with the OSDI questionnaire when changing maintenance system solution from multipurpose solution to hydrogen peroxide.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>This study included contact lens users for over a year as the multipurpose solution for the maintenance system, suffering from CLADE, and those who scored over 13 in the ocular surface disease index questionnaire, and did not manifest any clinical signs over 3 in the EFRON scale. The non-parametric data distribution was verified with the Kolmogorov-Smirnov test and Wilcoxon signed-rank test, which was used to compare the visual acuity (VA), OSDI score and bulbar redness (EFRON scale) of the follow-up visit against the baseline value.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>Thirty-eight patients were included. Analysing the clinical parameters between the initial and final visit after one month of hydrogen peroxide use, a statistically significant improvement was found in the VA, bulbar hyperemia, OSDI scale and their subscales of the total sample (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.04).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Conclusion<\/jats:title>\n               <jats:p>This study is intended as a first step towards a standardised protocol of actions to improve CLADE in an attempt to reduce contact lens dropout using OSDI as a tool for detection.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.18482","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T09:11:11Z","timestamp":1733476271000},"page":"e18482","source":"Crossref","is-referenced-by-count":1,"title":["Improvement of contact lens-associated dry eye disease with the use of hydrogen peroxide"],"prefix":"10.7717","volume":"12","author":[{"given":"Susana","family":"Castro","sequence":"first","affiliation":[{"name":"inGO Research Group, General Optica, Barcelona, Catalu\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Garcia-Aguilar","sequence":"additional","affiliation":[{"name":"inGO Research Group, General Optica, Barcelona, Catalu\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Garcia-Brion","sequence":"additional","affiliation":[{"name":"inGO Research Group, General Optica, Barcelona, Catalu\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"inGO Research Group, General Optica, Barcelona, Catalu\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Rosique","sequence":"additional","affiliation":[{"name":"inGO Research Group, General Optica, Barcelona, Catalu\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Ba\u00f1os","sequence":"additional","affiliation":[{"name":"inGO Research Group, General Optica, Barcelona, Catalu\u00f1a, Spain"},{"name":"Departamento de Optometr\u00eda y Visi\u00f3n, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica Te\u00f3rica At\u00f3mica y \u00d3ptica, Universidad de Valladolid, Valladolid,  Castilla y Leon, Spain"},{"name":"Optometry Research Group, IOBA Eye Institute, Valladolid, Castilla y Leon, 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