{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:11:52Z","timestamp":1735881112280,"version":"3.32.0"},"reference-count":30,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"crossref","award":["20232077"],"award-info":[{"award-number":["20232077"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Medical Science and Technology Research Fund","award":["A2024755"],"award-info":[{"award-number":["A2024755"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>The purpose of this study was to determine the efficacy and safety of low-dose radiotherapy (LDR) for postoperative local chest wall recurrence of breast cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The records of 52 patients with postoperative local chest wall recurrent breast cancer treated at our cancer center from January 2019 to December 2022. The t-test was used to compare the means of the LDR group and non LDR group. Categorical data were compared using the chi-square test. The Kaplan-Meier method were used to determine the factors associated the survival.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Compared to patients who did not undergo LDR, patients in the LDR group showed a higher incidence of grade I side effects in their skin and soft tissue systems (<jats:italic>p<\/jats:italic> = 0.002), a significant reduction in grade II side effects (<jats:italic>p<\/jats:italic> &lt; 0.05), and no grade III side effects. Compared with the non LDR group, the complete response rates were 42.3% <jats:italic>vs<\/jats:italic>. 38.5%, <jats:italic>p<\/jats:italic> = 0.777, the partial response rates were 53.8% <jats:italic>vs<\/jats:italic>. 50.0%, <jats:italic>p<\/jats:italic> = 0.781, and the objective relief rates were 96.2% <jats:italic>vs<\/jats:italic>. 88.5%, <jats:italic>p<\/jats:italic> = 0.833, respectively. The 3-year overall survival rate, local recurrence free survival rate, distant metastasis-free survival rate and disease-specific survival rate comparison between LDR group and non LDR group was 54.8% <jats:italic>vs<\/jats:italic>. 55.8%, <jats:italic>p<\/jats:italic> = 0.845 and 54.2% <jats:italic>vs<\/jats:italic>. 52.9%, <jats:italic>p<\/jats:italic> = 0.751, 67.9% <jats:italic>vs<\/jats:italic>. 51.9%, <jats:italic>p<\/jats:italic> = 0.097 and 39.2% <jats:italic>vs<\/jats:italic>. 49.6%, <jats:italic>p<\/jats:italic> = 0.993, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Compared with traditional radiotherapy, LDR pre-irradiation has better tolerance and efficacy in patients with local chest wall recurrence of breast cancer after operation.<\/jats:p>\n<\/jats:sec>","DOI":"10.7717\/peerj.18717","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T08:18:11Z","timestamp":1735805891000},"page":"e18717","source":"Crossref","is-referenced-by-count":0,"title":["Effect of low-dose radiation pre-irradiation on postoperative local chest wall recurrence of breast cancer\u2014A retrospective study"],"prefix":"10.7717","volume":"13","author":[{"given":"Ruifang","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Oncology, Cancer Center, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation, Sun Yat-sen University Cancer Center, Guangzhou, 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