{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:54:30Z","timestamp":1772268870702,"version":"3.50.1"},"reference-count":37,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R61AR078096"],"award-info":[{"award-number":["R61AR078096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Foundation","award":["1944001"],"award-info":[{"award-number":["1944001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The purpose of this study was to investigate the timing and mode of failure of metallic screw-type suture anchors used to attach artificial tendons to bone in an\n                      <jats:italic>in vivo<\/jats:italic>\n                      New Zealand White rabbit model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>\n                      Metal suture anchors with braided composite sutures of varying sizes (United States Pharmacopeia (USP) size 1, 2, or 5) were used to secure artificial tendons replacing both the Achilles and tibialis cranialis tendons in 12 female New Zealand White rabbits. Artificial tendons were implanted either at the time of (immediate replacement,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08), or four\/five weeks after (delayed replacement,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04) resection of the biological tendon. Hindlimb radiographs of the rabbits were obtained immediately after surgery and approximately every other week until the study endpoint (16 weeks post-surgery).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All suture anchors used for the tibialis cranialis artificial tendons remained secure and did not fail during the study. The suture anchor used to attach the Achilles artificial tendon to the calcaneus bone failed in nine of 12 rabbits. In all cases of suture anchor failure, the suture broke away from the knot, while the metallic screw remained securely embedded in the bone. Based on radiographic analysis, the mean estimated failure timepoint was 5.3 \u00b1\u00a02.3 weeks post-surgery, with a range of 2\u201310 weeks. Statistical analyses (Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test and Fisher\u2019s exact test) revealed no significant effect of tendon implantation timing or suture size on either the timing or frequency of suture anchor failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For the suture anchors used to attach artificial tendons in this study, suture anchor failure was most likely due to suture wear or cutting against the eyelet of the anchor screw. Future studies are needed to test the effect of suture-eyelet interaction on suture strength under different loading conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.18756","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:30:16Z","timestamp":1737430216000},"page":"e18756","source":"Crossref","is-referenced-by-count":2,"title":["Attaching artificial Achilles and tibialis cranialis tendons to bone using suture anchors in a rabbit model: assessment of outcomes"],"prefix":"10.7717","volume":"13","author":[{"given":"Obinna P.","family":"Fidelis","sequence":"first","affiliation":[{"name":"College of Engineering, University of Tennessee - Knoxville, TN, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb","family":"Stubbs","sequence":"additional","affiliation":[{"name":"College of Engineering, University of Tennessee - Knoxville, TN, United States of 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