{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:11:34Z","timestamp":1787069494803,"version":"build-2736575974"},"reference-count":37,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with end-stage renal disease (ESRD) have increased insulin resistance (IR). The triglyceride glucose (TyG) index is a marker of IR and is associated with the prognosis of patients on maintenance hemodialysis (MHD). The aim of this study was to examine the relationship between the TyG index and the risk of death in patients on MHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective cohort analysis of 368 patients with MHD over an 11-year period from July 1, 2012, to June 30, 2023, the TyG index and other baseline characteristics were measured at the beginning of MHD treatment. A regression model was used to evaluate the correlation between the TyG index and all-cause mortality or cardiovascular mortality in patients on MHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The TyG index was associated with all-cause mortality and cardiovascular mortality in MHD patients (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002 &amp;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.015). After adjusting for various confounding factors, the TyG index remained an independent predictor of all-cause mortality and cardiovascular mortality in MHD patients (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001 &amp;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.044). Compared with MHD patients with low TyG index levels, the risk of all-cause mortality and cardiovascular mortality in MHD patients with high TyG index levels increased by 1.790 and 1.735 times, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006 &amp;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.022). The predictive time-AUC values of the TyG index for all-cause and cardiovascular death in MHD patients were between 0.698 to 0.819.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The baseline TyG index may be an independent predictor of all-cause mortality and cardiovascular mortality in MHD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.7717\/peerj.18781","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T03:16:18Z","timestamp":1735787778000},"page":"e18781","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of the correlation between the serum triglyceride glucose index and the risk of death in patients on maintenance hemodialysis: a retrospective cohort study"],"prefix":"10.7717","volume":"13","author":[{"given":"Xiaokeng","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Nephrology, Blood Purification Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China"},{"name":"Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China"},{"name":"Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, Fuzhou, Fujian, China"},{"name":"Department of Nephrology, Blood Purification Research Center, Chaozhou People\u2019s Hospital, Chaozhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Blood Purification Research Center, Chaozhou People\u2019s Hospital, Chaozhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Chaozhou People\u2019s Hospital, Chaozhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Chaozhou People\u2019s Hospital, Chaozhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Blood Purification Research Center, Chaozhou People\u2019s Hospital, Chaozhou, Guangdong, China"},{"name":"Medical College, Shantou Uinversity, Shantou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujun","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Blood Purification Research Center, Chaozhou People\u2019s Hospital, Chaozhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Xu","sequence":"additional","affiliation":[{"name":"The Clincal Medical College, Jining Medical University, Jining, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-0472","authenticated-orcid":true,"given":"Jianxin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Blood Purification Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China"},{"name":"Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China"},{"name":"Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, Fuzhou, Fujian, 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