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Due to the high prevalence of diseases related to Western diets, the objective of this study was to evaluate whether the inclusion of a novel fiber-rich complex could prevent high fat diet-induced weight gain, adiposity, hyperglycemia, dyslipidemia, and oxidative stress in young male Sprague-Dawley rats, <jats:italic>Rattus norvegicus<\/jats:italic>. The novel fiber complex contained a blend of bioactive ingredients: 27% flaxseed, 15.9% wheat bran, 14.8% wheat germ, 10% psyllium, 13.1% brewer\u2019s yeast, and 19.2% grapeseed flour. The study included 24 6-week-old rats divided into three groups that were fed either a control diet (C; standard rodent maintenance diet) containing fiber (3.8%g diet); high-fat diet (H) containing Solka Floc cellulose fiber (6.46%g diet); or high-fat diet in which 5% of the diet was replaced with the novel fiber complex (HF) (total fiber: 5%g fiber complex + 6.14%g Solka Floc). Rats in all diet groups gained significant weight during the 6-week feeding period (<jats:italic>p<\/jats:italic> &lt; 0.001) consistent with normal growth. Whereas no differences were observed for blood lipids or beta-hydroxybutyrate, consumption of the H diet significantly increased adiposity (<jats:italic>p<\/jats:italic> &lt; 0.001), liver triglycerides (<jats:italic>p<\/jats:italic> &lt; 0.001), and fasting whole blood glucose concentrations (<jats:italic>p<\/jats:italic> &lt; 0.001) in comparison to the C diet. These effects of high fat consumption were not prevented by the inclusion of the novel fiber complex in this experimental design.<\/jats:p>","DOI":"10.7717\/peerj.19029","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T08:47:37Z","timestamp":1740041257000},"page":"e19029","source":"Crossref","is-referenced-by-count":1,"title":["Examination of a novel dietary fiber formulation on morphology and nutritional physiology of young male Sprague-Dawley rats fed a high fat diet"],"prefix":"10.7717","volume":"13","author":[{"given":"Milena","family":"Figueiredo de Sousa","sequence":"first","affiliation":[{"name":"College of Health Solutions, Arizona State University, Phoenix, Arizona, United States"},{"name":"School of Pharmacy, Universidade Federal de Goi\u00e1s, Goiania, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Ling","sequence":"additional","affiliation":[{"name":"College of Health Solutions, Arizona State 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