{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T04:59:07Z","timestamp":1781413147386,"version":"3.54.1"},"reference-count":32,"publisher":"PeerJ","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Municipal Health Commission Foundation","award":["202040076"],"award-info":[{"award-number":["202040076"]}]},{"name":"Shanghai Municipal Health Commission Foundation","award":["202140030"],"award-info":[{"award-number":["202140030"]}]},{"name":"Geriatrics Department Development Fund of Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","award":["JYXKA202012"],"award-info":[{"award-number":["JYXKA202012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n               <jats:title>Background<\/jats:title>\n               <jats:p>It remains uncertain whether a bedtime dose of selective \u03b11 adrenoceptor antagonist could result in nocturnal hypotension in elderly patients with benign prostate hyperplasia (BPH).<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Methods<\/jats:title>\n               <jats:p>A total of 253 older men with BPH who had taken selective \u03b11 adrenoceptor antagonists before sleep were consecutively recruited from the Geriatric Department of Shanghai Ninth People\u2019s Hospital. A total of 221 patients were finally included in the analysis with qualified data including office blood pressure examinations, biochemical tests of blood, and 24-hour ambulatory blood pressure monitoring. Nocturnal hypotension was defined according to the nighttime average systolic blood pressure of ambulatory blood pressure \u2264 100\u00a0mmHg and\/or diastolic blood pressure \u2264 60\u00a0mmHg. Explore the presence of night hypotension, compare the characteristics of the two groups with or without nocturnal hypotension, and analyze the related risk factors.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Results<\/jats:title>\n               <jats:p>Among all 221 patients included in the analysis, nocturnal hypotension occurred in 38 patients (17.2%). Compared with those without, patients with nocturnal hypotension were older, had less body mass index, lower office diastolic blood pressure, and lower ambulatory blood pressure in a 24 hour day, and night systolic and diastolic blood pressure, and were less likely to have hypertension. Age (OR 1.064, 95% CI [1.012\u20131.118], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) and no hypertension (OR 2.548, 95% CI [1.211\u20135.359], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014) were independently associated with the presence of nocturnal hypotension.<\/jats:p>\n            <\/jats:sec>\n            <jats:sec>\n               <jats:title>Discussion<\/jats:title>\n               <jats:p>Nocturnal hypotension was common in men 60 years and older with BPH treated with selective \u03b11 adrenoceptor antagonists before sleep. Age and no hypertension were independently associated with nocturnal hypotension positively. Related factors may help clinicians identify hypotension tendencies in the elderly when prescribing such drugs.<\/jats:p>\n            <\/jats:sec>","DOI":"10.7717\/peerj.19165","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T09:35:23Z","timestamp":1743500123000},"page":"e19165","source":"Crossref","is-referenced-by-count":2,"title":["A cross-sectional study on the effects of bedtime administration of selective \u03b11 adrenoceptor antagonists on nocturnal blood pressure in elderly patients with benign prostate hyperplasia"],"prefix":"10.7717","volume":"13","author":[{"given":"Chao-Ting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Urology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4443","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"10.7717\/peerj.19165\/ref-1","doi-asserted-by":"publisher","first-page":"n189","DOI":"10.1136\/bmj.n189","article-title":"Association between antihypertensive treatment and adverse events: systematic review and meta-analysis","volume":"372","author":"Albasri","year":"2021","journal-title":"BMJ"},{"key":"10.7717\/peerj.19165\/ref-2","doi-asserted-by":"publisher","first-page":"f6320","DOI":"10.1136\/bmj.f6320","article-title":"Tamsulosin treatment for benign prostatic hyperplasia and risk of severe hypotension in men aged, years in the United States: risk window analyses using between and within patient methodology","volume":"347","author":"Bird","year":"2013","journal-title":"BMJ"},{"issue":"1","key":"10.7717\/peerj.19165\/ref-3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1161\/HYPERTENSIONAHA.113.01838","article-title":"Association between ambulatory systolic blood pressure during the day and asymptomatic intracranial arterial stenosis","volume":"63","author":"Chen","year":"2014","journal-title":"Hypertension"},{"issue":"9","key":"10.7717\/peerj.19165\/ref-4","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1093\/ajh\/hpz074","article-title":"Extreme dipping: always means nocturnal hypotension?","volume":"32","author":"Cuspidi","year":"2019","journal-title":"American Journal of Hypertension"},{"issue":"9","key":"10.7717\/peerj.19165\/ref-5","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.jash.2016.06.035","article-title":"Hypotension based on office and ambulatory monitoring blood pressure. 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